The Therapeutic Response of Gastrointestinal Stromal Tumors to Imatinib Treatment Assessed by Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Histopathological Correlation
To exploit the intravoxel incoherent motion (IVIM) diffusion-weighted (DW) MRI when evaluating the therapeutic response of gastrointestinal stromal tumors (GIST) to Imatinib in a mouse model. Mice with xenografts bearing cells from the GIST-T1 cell line were randomly divided into a treated group rec...
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| creator | Pan, Feng Den, Jie Zhang, Chunfang Wang, He Cheng, Jin Wu, Weizhen Hong, Nan Wang, Yi |
| description | To exploit the intravoxel incoherent motion (IVIM) diffusion-weighted (DW) MRI when evaluating the therapeutic response of gastrointestinal stromal tumors (GIST) to Imatinib in a mouse model.
Mice with xenografts bearing cells from the GIST-T1 cell line were randomly divided into a treated group receiving Imatinib and a control group. DWMRI scans with 14 b-values (0-1500 s/mm2) were performed before and after treatment (days 1, 3 and 7). IVIM related parameters perfusion fractions (fp) and perfusion-related diffusion coefficients (D*) and the conventional apparent diffusion coefficients (ADC) were calculated by fitting the DWMRI signal decay. The mean changes from baseline to each post-treatment time point for each measurement (ΔADC, Δfp and ΔD*) were calculated. The differences of mean changes between the two groups were tested for statistical significance. Histopathological analyses including Ki-67, CD31, TUNEL and H&E were conducted in conjunction with the MRI scans.
Increases in ADC of the treated group were higher than those of the control group after treatment, whereas statistical significances were not observed. Compared to the control group, D* in the treated group decreased significantly (ΔD*treated = -41%, -49%, and -49% with P = 0.0001, 0.0001 and 0.0001), and fp increased significantly (Δfptreated = 79%, 82% and 110%, with P = 0.001, 0.0001 and P = 0.0007) on days 1, 3 and 7 after treatment. Histopathological analyses demonstrated different tumor tissue characteristics between the treated and control groups.
IVIM measurements may serve as more sensitive imaging biomarkers than ADC when assessing GIST response to Imatinib as early as one day after treatment. |
| doi_str_mv | 10.1371/journal.pone.0167720 |
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Mice with xenografts bearing cells from the GIST-T1 cell line were randomly divided into a treated group receiving Imatinib and a control group. DWMRI scans with 14 b-values (0-1500 s/mm2) were performed before and after treatment (days 1, 3 and 7). IVIM related parameters perfusion fractions (fp) and perfusion-related diffusion coefficients (D*) and the conventional apparent diffusion coefficients (ADC) were calculated by fitting the DWMRI signal decay. The mean changes from baseline to each post-treatment time point for each measurement (ΔADC, Δfp and ΔD*) were calculated. The differences of mean changes between the two groups were tested for statistical significance. Histopathological analyses including Ki-67, CD31, TUNEL and H&E were conducted in conjunction with the MRI scans.
Increases in ADC of the treated group were higher than those of the control group after treatment, whereas statistical significances were not observed. Compared to the control group, D* in the treated group decreased significantly (ΔD*treated = -41%, -49%, and -49% with P = 0.0001, 0.0001 and 0.0001), and fp increased significantly (Δfptreated = 79%, 82% and 110%, with P = 0.001, 0.0001 and P = 0.0007) on days 1, 3 and 7 after treatment. Histopathological analyses demonstrated different tumor tissue characteristics between the treated and control groups.
IVIM measurements may serve as more sensitive imaging biomarkers than ADC when assessing GIST response to Imatinib as early as one day after treatment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0167720</identifier><identifier>PMID: 27911930</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Apoptosis ; Bioindicators ; Biology and Life Sciences ; Biomarkers ; Cancer therapies ; Care and treatment ; Cell Line, Tumor ; Diffusion ; Diffusion coefficient ; Dosage and administration ; Female ; Gastrointestinal cancer ; Gastrointestinal Neoplasms - diagnostic imaging ; Gastrointestinal Neoplasms - drug therapy ; Gastrointestinal Stromal Tumors - diagnostic imaging ; Gastrointestinal Stromal Tumors - drug therapy ; Gastrointestinal tumors ; Growth factors ; Humans ; Imatinib ; Imatinib mesylate ; Imatinib Mesylate - pharmacology ; Inhibitor drugs ; Laboratory animals ; Liver cancer ; Magnetic resonance ; Magnetic Resonance Imaging ; Medical imaging ; Medicine and Health Sciences ; Metastasis ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; NMR ; Nuclear magnetic resonance ; Pathological histology ; Perfusion ; Physical Sciences ; Research and Analysis Methods ; Risk factors ; Statistical analysis ; Statistics ; Targeted cancer therapy ; Tumors ; Xenograft Model Antitumor Assays ; Xenografts</subject><ispartof>PloS one, 2016-12, Vol.11 (12), p.e0167720-e0167720</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Pan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Pan et al 2016 Pan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c686t-12b2ad5f64e1a2a0eeaf530de4fdca14ec83dd09174f82cb26972c042903dfc43</citedby><cites>FETCH-LOGICAL-c686t-12b2ad5f64e1a2a0eeaf530de4fdca14ec83dd09174f82cb26972c042903dfc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135126/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135126/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27911930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pan, Feng</creatorcontrib><creatorcontrib>Den, Jie</creatorcontrib><creatorcontrib>Zhang, Chunfang</creatorcontrib><creatorcontrib>Wang, He</creatorcontrib><creatorcontrib>Cheng, Jin</creatorcontrib><creatorcontrib>Wu, Weizhen</creatorcontrib><creatorcontrib>Hong, Nan</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><title>The Therapeutic Response of Gastrointestinal Stromal Tumors to Imatinib Treatment Assessed by Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Histopathological Correlation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To exploit the intravoxel incoherent motion (IVIM) diffusion-weighted (DW) MRI when evaluating the therapeutic response of gastrointestinal stromal tumors (GIST) to Imatinib in a mouse model.
Mice with xenografts bearing cells from the GIST-T1 cell line were randomly divided into a treated group receiving Imatinib and a control group. DWMRI scans with 14 b-values (0-1500 s/mm2) were performed before and after treatment (days 1, 3 and 7). IVIM related parameters perfusion fractions (fp) and perfusion-related diffusion coefficients (D*) and the conventional apparent diffusion coefficients (ADC) were calculated by fitting the DWMRI signal decay. The mean changes from baseline to each post-treatment time point for each measurement (ΔADC, Δfp and ΔD*) were calculated. The differences of mean changes between the two groups were tested for statistical significance. Histopathological analyses including Ki-67, CD31, TUNEL and H&E were conducted in conjunction with the MRI scans.
Increases in ADC of the treated group were higher than those of the control group after treatment, whereas statistical significances were not observed. Compared to the control group, D* in the treated group decreased significantly (ΔD*treated = -41%, -49%, and -49% with P = 0.0001, 0.0001 and 0.0001), and fp increased significantly (Δfptreated = 79%, 82% and 110%, with P = 0.001, 0.0001 and P = 0.0007) on days 1, 3 and 7 after treatment. Histopathological analyses demonstrated different tumor tissue characteristics between the treated and control groups.
IVIM measurements may serve as more sensitive imaging biomarkers than ADC when assessing GIST response to Imatinib as early as one day after treatment.</description><subject>Analysis</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Bioindicators</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cell Line, Tumor</subject><subject>Diffusion</subject><subject>Diffusion coefficient</subject><subject>Dosage and administration</subject><subject>Female</subject><subject>Gastrointestinal cancer</subject><subject>Gastrointestinal Neoplasms - diagnostic imaging</subject><subject>Gastrointestinal Neoplasms - drug therapy</subject><subject>Gastrointestinal Stromal Tumors - diagnostic imaging</subject><subject>Gastrointestinal Stromal Tumors - drug therapy</subject><subject>Gastrointestinal tumors</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Imatinib</subject><subject>Imatinib mesylate</subject><subject>Imatinib Mesylate - pharmacology</subject><subject>Inhibitor drugs</subject><subject>Laboratory animals</subject><subject>Liver cancer</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pathological histology</subject><subject>Perfusion</subject><subject>Physical Sciences</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Statistics</subject><subject>Targeted cancer therapy</subject><subject>Tumors</subject><subject>Xenograft Model Antitumor Assays</subject><subject>Xenografts</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk21r1TAUx4soTqffQDQgiL64M499eCOMqduFjcF21ZchNz1tM9rkmqRz-4x-KVPXjV3xxaAlp80v__PPSU6WvSJ4j7CCfLxwo7eq39s4C3uY5EVB8aPsGakYXeQUs8f34p3seQgXGAtW5vnTbIcWFUmT-Fn2e9UBSq9XGxij0egMQlIMgFyDDlWI3hkbIUSTcqHz9DmkcTUOzgcUHVoOKk2ZNVp5UHEAG9F-CJCeGq2v0dJGry7dFfQp1C7lmYgTF42z6LNpmjGkaPEDTNvFtOREtRZmG84qq2HK0Brbol8mdujIhOg2Knaud63RycqB8x56NQm-yJ40qg_wch53s29fv6wOjhbHp4fLg_3jhc7LPC4IXVNViybnQBRVGEA1guEaeFNrRTjoktU1rkjBm5LqNc2rgmrMaYVZ3WjOdrM3N7qb3gU5n0OQpOSCY55KnIjlDVE7dSE33gzKX0unjPz7w_lWKp-22YMssCgFFawQVconmopW65riHEoGvGQiaX2as43rAWoNU0n7LdHtGWs62bpLKQgThE5m3s8C3v0c01HKwQQNfa8suHHynZeMJAf0ASgXJaMET7be_oP-vxAz1aq0V2MblyzqSVTu84LyVNRqoj5sUdqlK3cVWzWGIJfnZw9nT79vs-_usR2oPnbB9eN0WcI2yG9A7V0IHpq78hIsp2673Zycuk3O3ZaWvb5_NHeLbtuL_QHN_inh</recordid><startdate>20161202</startdate><enddate>20161202</enddate><creator>Pan, Feng</creator><creator>Den, Jie</creator><creator>Zhang, Chunfang</creator><creator>Wang, He</creator><creator>Cheng, Jin</creator><creator>Wu, Weizhen</creator><creator>Hong, Nan</creator><creator>Wang, Yi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20161202</creationdate><title>The Therapeutic Response of Gastrointestinal Stromal Tumors to Imatinib Treatment Assessed by Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Histopathological Correlation</title><author>Pan, Feng ; Den, Jie ; Zhang, Chunfang ; Wang, He ; Cheng, Jin ; Wu, Weizhen ; Hong, Nan ; Wang, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c686t-12b2ad5f64e1a2a0eeaf530de4fdca14ec83dd09174f82cb26972c042903dfc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Bioindicators</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Cell Line, Tumor</topic><topic>Diffusion</topic><topic>Diffusion coefficient</topic><topic>Dosage and administration</topic><topic>Female</topic><topic>Gastrointestinal cancer</topic><topic>Gastrointestinal Neoplasms - diagnostic imaging</topic><topic>Gastrointestinal Neoplasms - drug therapy</topic><topic>Gastrointestinal Stromal Tumors - diagnostic imaging</topic><topic>Gastrointestinal Stromal Tumors - drug therapy</topic><topic>Gastrointestinal tumors</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Imatinib</topic><topic>Imatinib mesylate</topic><topic>Imatinib Mesylate - pharmacology</topic><topic>Inhibitor drugs</topic><topic>Laboratory animals</topic><topic>Liver cancer</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pathological histology</topic><topic>Perfusion</topic><topic>Physical Sciences</topic><topic>Research and Analysis Methods</topic><topic>Risk factors</topic><topic>Statistical analysis</topic><topic>Statistics</topic><topic>Targeted cancer therapy</topic><topic>Tumors</topic><topic>Xenograft Model Antitumor Assays</topic><topic>Xenografts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Feng</creatorcontrib><creatorcontrib>Den, Jie</creatorcontrib><creatorcontrib>Zhang, Chunfang</creatorcontrib><creatorcontrib>Wang, He</creatorcontrib><creatorcontrib>Cheng, Jin</creatorcontrib><creatorcontrib>Wu, Weizhen</creatorcontrib><creatorcontrib>Hong, Nan</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Feng</au><au>Den, Jie</au><au>Zhang, Chunfang</au><au>Wang, He</au><au>Cheng, Jin</au><au>Wu, Weizhen</au><au>Hong, Nan</au><au>Wang, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Therapeutic Response of Gastrointestinal Stromal Tumors to Imatinib Treatment Assessed by Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Histopathological Correlation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-12-02</date><risdate>2016</risdate><volume>11</volume><issue>12</issue><spage>e0167720</spage><epage>e0167720</epage><pages>e0167720-e0167720</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To exploit the intravoxel incoherent motion (IVIM) diffusion-weighted (DW) MRI when evaluating the therapeutic response of gastrointestinal stromal tumors (GIST) to Imatinib in a mouse model.
Mice with xenografts bearing cells from the GIST-T1 cell line were randomly divided into a treated group receiving Imatinib and a control group. DWMRI scans with 14 b-values (0-1500 s/mm2) were performed before and after treatment (days 1, 3 and 7). IVIM related parameters perfusion fractions (fp) and perfusion-related diffusion coefficients (D*) and the conventional apparent diffusion coefficients (ADC) were calculated by fitting the DWMRI signal decay. The mean changes from baseline to each post-treatment time point for each measurement (ΔADC, Δfp and ΔD*) were calculated. The differences of mean changes between the two groups were tested for statistical significance. Histopathological analyses including Ki-67, CD31, TUNEL and H&E were conducted in conjunction with the MRI scans.
Increases in ADC of the treated group were higher than those of the control group after treatment, whereas statistical significances were not observed. Compared to the control group, D* in the treated group decreased significantly (ΔD*treated = -41%, -49%, and -49% with P = 0.0001, 0.0001 and 0.0001), and fp increased significantly (Δfptreated = 79%, 82% and 110%, with P = 0.001, 0.0001 and P = 0.0007) on days 1, 3 and 7 after treatment. Histopathological analyses demonstrated different tumor tissue characteristics between the treated and control groups.
IVIM measurements may serve as more sensitive imaging biomarkers than ADC when assessing GIST response to Imatinib as early as one day after treatment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27911930</pmid><doi>10.1371/journal.pone.0167720</doi><tpages>e0167720</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Animals Apoptosis Bioindicators Biology and Life Sciences Biomarkers Cancer therapies Care and treatment Cell Line, Tumor Diffusion Diffusion coefficient Dosage and administration Female Gastrointestinal cancer Gastrointestinal Neoplasms - diagnostic imaging Gastrointestinal Neoplasms - drug therapy Gastrointestinal Stromal Tumors - diagnostic imaging Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal tumors Growth factors Humans Imatinib Imatinib mesylate Imatinib Mesylate - pharmacology Inhibitor drugs Laboratory animals Liver cancer Magnetic resonance Magnetic Resonance Imaging Medical imaging Medicine and Health Sciences Metastasis Mice Mice, Inbred BALB C Mice, Nude NMR Nuclear magnetic resonance Pathological histology Perfusion Physical Sciences Research and Analysis Methods Risk factors Statistical analysis Statistics Targeted cancer therapy Tumors Xenograft Model Antitumor Assays Xenografts |
| title | The Therapeutic Response of Gastrointestinal Stromal Tumors to Imatinib Treatment Assessed by Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Histopathological Correlation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T12%3A16%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Therapeutic%20Response%20of%20Gastrointestinal%20Stromal%20Tumors%20to%20Imatinib%20Treatment%20Assessed%20by%20Intravoxel%20Incoherent%20Motion%20Diffusion-Weighted%20Magnetic%20Resonance%20Imaging%20with%20Histopathological%20Correlation&rft.jtitle=PloS%20one&rft.au=Pan,%20Feng&rft.date=2016-12-02&rft.volume=11&rft.issue=12&rft.spage=e0167720&rft.epage=e0167720&rft.pages=e0167720-e0167720&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0167720&rft_dat=%3Cgale_plos_%3EA472442996%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1845404386&rft_id=info:pmid/27911930&rft_galeid=A472442996&rft_doaj_id=oai_doaj_org_article_7058525375974f5f929bd206e83e4835&rfr_iscdi=true |