Novel Aryl Hydrocarbon Receptor Agonist Suppresses Migration and Invasion of Breast Cancer Cells

Despite the remarkable progress to fight against breast cancer, metastasis remains the dominant cause of treatment failure and recurrence. Therefore, control of invasiveness potential of breast cancer cells is crucial. Accumulating evidences suggest Aryl hydrocarbon receptor (Ahr), a helix-loop-heli...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0167650-e0167650
Hauptverfasser:	Hanieh, Hamza, Mohafez, Omar, Hairul-Islam, Villianur Ibrahim, Alzahrani, Abdullah, Bani Ismail, Mohammad, Thirugnanasambantham, Krishnaraj
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Aromatic compounds B-cell lymphoma Bioinformatics Biology and Life Sciences Biotechnology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cancer metastasis Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell receptors Cytochrome Cytochrome P450 Development and progression Drug therapy Electroporation Female Flavonoids Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Helix-loop-helix Helix-loop-helix proteins Humans Hydrocarbons Invasiveness Ligands Lymphocytes B Lymphoma Medicine and Health Sciences Metastases Metastasis MicroRNAs miRNA Molecular Conformation Molecular Docking Simulation Motility Neoplasm Invasiveness - pathology Neoplasm Metastasis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology o-Phthalaldehyde - administration & dosage o-Phthalaldehyde - analogs & derivatives Pharmacy Phosphorylation Physical Sciences Physiological aspects Proteins Receptors, Aryl Hydrocarbon - agonists Receptors, Aryl Hydrocarbon - chemistry Receptors, Aryl Hydrocarbon - genetics Science Transcription factors
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