Molecular Characterization of Two Monoclonal Antibodies against the Same Epitope on B-Cell Receptor Associated Protein 31

Previously, we showed that B-cell receptor associated protein 31 (BAP31), an endoplasmic reticulum (ER) membrane chaperone, is also expressed on the cell surface by two monoclonal antibodies (MAbs) 297-D4 and 144-A8. Both MAbs recognize the same linear epitope on the C-terminal domain of BAP31, alth...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0167527-e0167527
Hauptverfasser:	Kim, Won-Tae, Shin, Saemina, Hwang, Hyo Jeong, Kim, Min Kyu, Jung, Han-Sung, Park, Hwangseo, Ryu, Chun Jeih
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino Acid Sequence Amino acids Analysis Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibody Affinity Antibody Specificity Antigens Apoptosis B cells B-cell receptor B-Lymphocytes - chemistry B-Lymphocytes - immunology Binding Binding Sites, Antibody Biology and Life Sciences Biotechnology Cancer Cell adhesion & migration Cell surface Chains Chemical bonds Chromatography Cloning Cloning, Molecular Complementarity Complementarity Determining Regions - chemistry Complementarity Determining Regions - immunology Dentistry Endoplasmic reticulum Enzymes Epitopes Epitopes - chemistry Epitopes - genetics Epitopes - immunology Escherichia coli - genetics Escherichia coli - metabolism Flow cytometry Gene Expression Heavy chains Humans Hydrogen Hydrogen Bonding Hydrogen bonds Hydrogen ion concentration Hydrophobic and Hydrophilic Interactions Hydrophobicity Immunization Immunoglobulin Variable Region - chemistry Immunoglobulin Variable Region - genetics Immunoglobulins Leucine Lymphocytes B Medicine Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - immunology Mice Microenvironments Molecular Docking Simulation Molecular Dynamics Simulation Molecular modelling Monoclonal antibodies Physical Sciences Protein Binding Protein Conformation Proteins Receptors, Antigen, B-Cell - chemistry Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Research and Analysis Methods Sequence Alignment Stem cells Variable region
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