Quantification of Arachidonic Acid and Its Metabolites in Rat Tissues by UHPLC-MS/MS: Application for the Identification of Potential Biomarkers of Benign Prostatic Hyperplasia

To evaluate the potential relationship between benign prostatic hyperplasia (BPH) and the arachidonic acid (AA) metabolome, a UHPLC-MS/MS method has been developed and validated for simultaneous determination of AA and its cyclooxygenase(COX) and lipoxygenase(LOX) pathway metabolites (15-HETE, 12-HE...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166777-e0166777
Hauptverfasser:	Bian, Qiaoxia, Wang, Weihui, Wang, Nannan, Peng, Yan, Ma, Wen, Dai, Ronghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Acids Ammonia Analysis Analytical chemistry Animal tissues Animals Arachidonic acid Arachidonic Acid - analysis Arachidonic Acid - metabolism Benign Bioindicators Biological markers Biology and Life Sciences Biomarkers Biomarkers - analysis Biomarkers - metabolism Bladder Calibration Chromatography, High Pressure Liquid - methods Column packings Diagnosis Dilution Eicosanoids Eicosanoids - analysis Eicosanoids - metabolism Enzymes Formic acid Genital diseases Health aspects Hyperplasia Inflammation Ionization Kidney - metabolism Kidneys Lipids Lipoxygenase Liquid oxygen Liver Liver - metabolism Male Medicine and Health Sciences Metabolism Metabolites Pharmaceuticals Pharmacy Prostaglandin E2 Prostaglandin endoperoxide synthase Prostate Prostate - metabolism Prostate - pathology Prostatic hyperplasia Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Rats, Sprague-Dawley Reproducibility of Results Rodents Sensitivity and Specificity Signal transduction Tandem Mass Spectrometry - methods Testosterone Urinary Bladder - metabolism Urology
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