Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review
Galactose-deficient IgA1 was evaluated in patients with IgA nephropathy(IgAN) and controls in order to determine the predictive value of galactose-deficient IgA1 in cases of IgA nephropathy. PubMed, EMBASE, Cochrane central register of controlled trials, CNKI, CBM disc, and VIP database were searche...
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| description | Galactose-deficient IgA1 was evaluated in patients with IgA nephropathy(IgAN) and controls in order to determine the predictive value of galactose-deficient IgA1 in cases of IgA nephropathy.
PubMed, EMBASE, Cochrane central register of controlled trials, CNKI, CBM disc, and VIP database were searched to identify eligible studies that evaluated a difference in aberrant IgA1 glycosylation in IgAN patients compared with controls. A meta-analysis was conducted to evaluate the impact of galactose-deficient IgA1(Gd-IgA1) levels in different groups.
A total of 22 studies (n = 1657) met inclusion criteria. The mean Newcastle-Ottawa Scale (NOS) score was 7.2 and ranged from 6 to 8. The standard mean difference(SMD) in the meta-analysis of 20 studies of the level of Gd-IgA1 in the serum and/or supernatant of cultured cells was higher in the IgAN group compared with healthy controls as well as in those with other renal diseases (SMD = 1.76, 95% CI = 1.18-2.34, P |
| doi_str_mv | 10.1371/journal.pone.0166700 |
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PubMed, EMBASE, Cochrane central register of controlled trials, CNKI, CBM disc, and VIP database were searched to identify eligible studies that evaluated a difference in aberrant IgA1 glycosylation in IgAN patients compared with controls. A meta-analysis was conducted to evaluate the impact of galactose-deficient IgA1(Gd-IgA1) levels in different groups.
A total of 22 studies (n = 1657) met inclusion criteria. The mean Newcastle-Ottawa Scale (NOS) score was 7.2 and ranged from 6 to 8. The standard mean difference(SMD) in the meta-analysis of 20 studies of the level of Gd-IgA1 in the serum and/or supernatant of cultured cells was higher in the IgAN group compared with healthy controls as well as in those with other renal diseases (SMD = 1.76, 95% CI = 1.18-2.34, P<0.00001; SMD = 1.05, 95% CI = 0.05-2.04, P = 0.04). The data synthesis suggested that IgAN patients had similar levels of serum Gd-IgA1, with no significant differences, compared with first-degree relatives and Henoch-Schonlein purpura nephritis (HSPN) patients (MD = 0.04, 95% CI = 0.00-0.08, P = 0.05; MD = -46.03, 95% CI = -217.70-125.64, P = 0.60). In addition, the combined MD of 5 studies indicated that there were no significant differences in Gd-IgA1 levels among patients with varying severities of IgAN (MD = 0.02, 95% CI = -0.02-0.05, P = 0.28).
The pooled evidence suggests that the level of Gd-IgA1 in the serum or supernatant of cultured cells from peripheral blood or tonsils may be a useful biomarker for predicting IgA nephropathy, though the level of Gd-IgA1 was not significantly associated with disease severity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0166700</identifier><identifier>PMID: 27870872</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Biomarkers - chemistry ; Biopsy ; Clinical trials ; Comparative analysis ; DNA methylation ; Early Diagnosis ; Female ; Gadolinium ; Galactose ; Galactose - metabolism ; Gene expression ; Glomerulonephritis, IGA - immunology ; Glycosylation ; Hospitals ; Humans ; IgA nephropathy ; Immunoglobulin A ; Immunoglobulin A - blood ; Immunoglobulin A - chemistry ; Immunoglobulins ; Immunology ; Kidney diseases ; Kidney transplantation ; Laboratories ; Male ; Mass spectrometry ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Nephritis ; Nephrology ; Nitric-oxide synthase ; Patients ; Pediatrics ; Peripheral blood ; Physical Sciences ; Predictive control ; Randomized Controlled Trials as Topic ; Research and Analysis Methods ; Schonlein-Henoch purpura ; Scientific imaging ; Studies ; Systematic review ; Systemic diseases ; Vasoactive intestinal peptide</subject><ispartof>PloS one, 2016-11, Vol.11 (11), p.e0166700-e0166700</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Sun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Sun et al 2016 Sun et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c7060-8bbaae07c2bd1f38d7187012bcc39d1c745fc7fac6d57acc5396e037a8e32b103</citedby><cites>FETCH-LOGICAL-c7060-8bbaae07c2bd1f38d7187012bcc39d1c745fc7fac6d57acc5396e037a8e32b103</cites><orcidid>0000-0003-4037-7497</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27870872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mariat, Christophe</contributor><creatorcontrib>Sun, Qiang</creatorcontrib><creatorcontrib>Zhang, Zhenhai</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Liu, Xiaorong</creatorcontrib><title>Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Galactose-deficient IgA1 was evaluated in patients with IgA nephropathy(IgAN) and controls in order to determine the predictive value of galactose-deficient IgA1 in cases of IgA nephropathy.
PubMed, EMBASE, Cochrane central register of controlled trials, CNKI, CBM disc, and VIP database were searched to identify eligible studies that evaluated a difference in aberrant IgA1 glycosylation in IgAN patients compared with controls. A meta-analysis was conducted to evaluate the impact of galactose-deficient IgA1(Gd-IgA1) levels in different groups.
A total of 22 studies (n = 1657) met inclusion criteria. The mean Newcastle-Ottawa Scale (NOS) score was 7.2 and ranged from 6 to 8. The standard mean difference(SMD) in the meta-analysis of 20 studies of the level of Gd-IgA1 in the serum and/or supernatant of cultured cells was higher in the IgAN group compared with healthy controls as well as in those with other renal diseases (SMD = 1.76, 95% CI = 1.18-2.34, P<0.00001; SMD = 1.05, 95% CI = 0.05-2.04, P = 0.04). The data synthesis suggested that IgAN patients had similar levels of serum Gd-IgA1, with no significant differences, compared with first-degree relatives and Henoch-Schonlein purpura nephritis (HSPN) patients (MD = 0.04, 95% CI = 0.00-0.08, P = 0.05; MD = -46.03, 95% CI = -217.70-125.64, P = 0.60). In addition, the combined MD of 5 studies indicated that there were no significant differences in Gd-IgA1 levels among patients with varying severities of IgAN (MD = 0.02, 95% CI = -0.02-0.05, P = 0.28).
The pooled evidence suggests that the level of Gd-IgA1 in the serum or supernatant of cultured cells from peripheral blood or tonsils may be a useful biomarker for predicting IgA nephropathy, though the level of Gd-IgA1 was not significantly associated with disease severity.</description><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - chemistry</subject><subject>Biopsy</subject><subject>Clinical trials</subject><subject>Comparative analysis</subject><subject>DNA methylation</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Gadolinium</subject><subject>Galactose</subject><subject>Galactose - metabolism</subject><subject>Gene expression</subject><subject>Glomerulonephritis, IGA - immunology</subject><subject>Glycosylation</subject><subject>Hospitals</subject><subject>Humans</subject><subject>IgA nephropathy</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin A - chemistry</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Laboratories</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Nephritis</subject><subject>Nephrology</subject><subject>Nitric-oxide synthase</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Peripheral blood</subject><subject>Physical Sciences</subject><subject>Predictive control</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Research and Analysis Methods</subject><subject>Schonlein-Henoch purpura</subject><subject>Scientific imaging</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Systemic diseases</subject><subject>Vasoactive intestinal peptide</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkJw0eKPOHa4QKoqGJUmJm3AreXYJ20qNw52Mui_x6HZ1KBdTL6wdfyc1-fDJ0leYjTHlOMPW9f7Rtl56xqYI5znHKFHySkuKJnlBNHHR-eT5FkIW4QYFXn-NDkhXHAkODlNlosSvFdNl67WC5ye2712YW9VV7smrZvBmn6DduNdq7rN_mO6SK_3oYNdJHR6BTc1_H6ePKmUDfBi3M-SH18-f19-nV1cnq-Wi4uZ5ihHM1GWSgHimpQGV1QYjmMUmJRa08JgzTNWaV4pnRvGldaMFjkgypUASkqM6Fny-qDbWhfkmH-QWGQEU0aoiMTqQBintrL19U75vXSqlv8Mzq-l8jFwC1Jog1jByzIvIEM8K3KKlSYGWGUMKyFqfRpf68sdGA1N55WdiE5vmnoj1-5GMow5RyQKvBsFvPvVQ-jkrg4arFUNuH6ImyEuKCbiAWhGcoQxLSL65j_0_kKM1FrFXOumcjFEPYjKRRbrXjAuhoLO76HiMrCrdfxXVR3tE4f3E4fIdPCnW6s-BLm6vno4e_lzyr49YjegbLcJzvbDLwxTMDuA2rsQPFR3_cBIDmNxWw05jIUcxyK6vTru5Z3T7RzQv7CmBc0</recordid><startdate>20161121</startdate><enddate>20161121</enddate><creator>Sun, Qiang</creator><creator>Zhang, Zhenhai</creator><creator>Zhang, Hong</creator><creator>Liu, Xiaorong</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4037-7497</orcidid></search><sort><creationdate>20161121</creationdate><title>Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review</title><author>Sun, Qiang ; Zhang, Zhenhai ; Zhang, Hong ; Liu, Xiaorong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c7060-8bbaae07c2bd1f38d7187012bcc39d1c745fc7fac6d57acc5396e037a8e32b103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - chemistry</topic><topic>Biopsy</topic><topic>Clinical trials</topic><topic>Comparative analysis</topic><topic>DNA methylation</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Gadolinium</topic><topic>Galactose</topic><topic>Galactose - metabolism</topic><topic>Gene expression</topic><topic>Glomerulonephritis, IGA - immunology</topic><topic>Glycosylation</topic><topic>Hospitals</topic><topic>Humans</topic><topic>IgA nephropathy</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin A - chemistry</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Kidney diseases</topic><topic>Kidney transplantation</topic><topic>Laboratories</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Nephritis</topic><topic>Nephrology</topic><topic>Nitric-oxide synthase</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Peripheral blood</topic><topic>Physical Sciences</topic><topic>Predictive control</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Research and Analysis Methods</topic><topic>Schonlein-Henoch purpura</topic><topic>Scientific imaging</topic><topic>Studies</topic><topic>Systematic review</topic><topic>Systemic diseases</topic><topic>Vasoactive intestinal peptide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Qiang</creatorcontrib><creatorcontrib>Zhang, Zhenhai</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Liu, Xiaorong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Qiang</au><au>Zhang, Zhenhai</au><au>Zhang, Hong</au><au>Liu, Xiaorong</au><au>Mariat, Christophe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-11-21</date><risdate>2016</risdate><volume>11</volume><issue>11</issue><spage>e0166700</spage><epage>e0166700</epage><pages>e0166700-e0166700</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Galactose-deficient IgA1 was evaluated in patients with IgA nephropathy(IgAN) and controls in order to determine the predictive value of galactose-deficient IgA1 in cases of IgA nephropathy.
PubMed, EMBASE, Cochrane central register of controlled trials, CNKI, CBM disc, and VIP database were searched to identify eligible studies that evaluated a difference in aberrant IgA1 glycosylation in IgAN patients compared with controls. A meta-analysis was conducted to evaluate the impact of galactose-deficient IgA1(Gd-IgA1) levels in different groups.
A total of 22 studies (n = 1657) met inclusion criteria. The mean Newcastle-Ottawa Scale (NOS) score was 7.2 and ranged from 6 to 8. The standard mean difference(SMD) in the meta-analysis of 20 studies of the level of Gd-IgA1 in the serum and/or supernatant of cultured cells was higher in the IgAN group compared with healthy controls as well as in those with other renal diseases (SMD = 1.76, 95% CI = 1.18-2.34, P<0.00001; SMD = 1.05, 95% CI = 0.05-2.04, P = 0.04). The data synthesis suggested that IgAN patients had similar levels of serum Gd-IgA1, with no significant differences, compared with first-degree relatives and Henoch-Schonlein purpura nephritis (HSPN) patients (MD = 0.04, 95% CI = 0.00-0.08, P = 0.05; MD = -46.03, 95% CI = -217.70-125.64, P = 0.60). In addition, the combined MD of 5 studies indicated that there were no significant differences in Gd-IgA1 levels among patients with varying severities of IgAN (MD = 0.02, 95% CI = -0.02-0.05, P = 0.28).
The pooled evidence suggests that the level of Gd-IgA1 in the serum or supernatant of cultured cells from peripheral blood or tonsils may be a useful biomarker for predicting IgA nephropathy, though the level of Gd-IgA1 was not significantly associated with disease severity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27870872</pmid><doi>10.1371/journal.pone.0166700</doi><orcidid>https://orcid.org/0000-0003-4037-7497</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Biology and Life Sciences Biomarkers Biomarkers - blood Biomarkers - chemistry Biopsy Clinical trials Comparative analysis DNA methylation Early Diagnosis Female Gadolinium Galactose Galactose - metabolism Gene expression Glomerulonephritis, IGA - immunology Glycosylation Hospitals Humans IgA nephropathy Immunoglobulin A Immunoglobulin A - blood Immunoglobulin A - chemistry Immunoglobulins Immunology Kidney diseases Kidney transplantation Laboratories Male Mass spectrometry Medical research Medicine and Health Sciences Meta-analysis Nephritis Nephrology Nitric-oxide synthase Patients Pediatrics Peripheral blood Physical Sciences Predictive control Randomized Controlled Trials as Topic Research and Analysis Methods Schonlein-Henoch purpura Scientific imaging Studies Systematic review Systemic diseases Vasoactive intestinal peptide |
| title | Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T02%3A12%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aberrant%20IgA1%20Glycosylation%20in%20IgA%20Nephropathy:%20A%20Systematic%20Review&rft.jtitle=PloS%20one&rft.au=Sun,%20Qiang&rft.date=2016-11-21&rft.volume=11&rft.issue=11&rft.spage=e0166700&rft.epage=e0166700&rft.pages=e0166700-e0166700&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0166700&rft_dat=%3Cgale_plos_%3EA471895780%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1842135238&rft_id=info:pmid/27870872&rft_galeid=A471895780&rft_doaj_id=oai_doaj_org_article_8cd0597bb69e40749631ac2de5fdd5be&rfr_iscdi=true |