Modelling and Simulation of the Dynamics of the Antigen-Specific T Cell Response Using Variable Structure Control Theory

Experimental and mathematical studies in immunology have revealed that the dynamics of the programmed T cell response to vigorous infection can be conveniently modelled using a sigmoidal or a discontinuous immune response function. This paper hypothesizes strong synergies between this existing work...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166163-e0166163
Hauptverfasser:	Anelone, Anet J N, Spurgeon, Sarah K
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Animals Antigens Antigens - immunology Arenaviridae Biology Biology and Life Sciences CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell death Chronic infection Computer Simulation Control algorithms Control engineering Control systems Control theory Drug development Dynamic structural analysis Engineering schools Epitopes, T-Lymphocyte - immunology Health aspects HIV Host-Pathogen Interactions - immunology Human immunodeficiency virus Immune response Immune system Immunologic Memory Immunology Infection Infections Lymphocytes Lymphocytes T Lymphocytic Choriomeningitis - immunology Lymphocytic choriomeningitis virus - immunology Mathematical models Medical research Medicine and Health Sciences Mice Models, Immunological Pathogens Population Response functions Robustness (mathematics) Simulation T cell receptors T cells T-Lymphocytes - immunology Variable structure control Virology Viruses
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