Cold Exposure Induces Proliferation of Mature Brown Adipocyte in a ß3-Adrenergic Receptor-Mediated Pathway

Hyperplasia of brown adipose tissue (BAT) is a fundamental mechanism for adaptation to survive in the cold environment in rodents. To determine which cell types comprising BAT contribute to tissue hyperplasia, immunohistochemical analysis using a proliferative marker Ki67 was performed on the BAT fr...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166579-e0166579
Hauptverfasser:	Fukano, Keigo, Okamatsu-Ogura, Yuko, Tsubota, Ayumi, Nio-Kobayashi, Junko, Kimura, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - genetics Adipocytes Adipocytes, Brown - metabolism Adipocytes, Brown - physiology Adipose tissue Adipose tissue (brown) Adrenergic beta-3 Receptor Agonists - administration & dosage Adrenergic receptors Analysis Angiogenesis Animals Antigens Biology and Life Sciences Cell growth Cell proliferation Cell Proliferation - genetics Cold Cold Temperature Endocrinology Experiments Exposure Gene expression Gene Expression Regulation House mouse Hyperplasia Hyperplasia - genetics Immunoglobulins Ki-67 Antigen - biosynthesis Ki-67 Antigen - genetics Laboratory animals Medical research Medicine and Health Sciences Mice Nuclei Nuclei (cytology) Preadipocytes Proteins Receptors, Adrenergic, beta-1 - biosynthesis Receptors, Adrenergic, beta-1 - genetics Receptors, Adrenergic, beta-3 - biosynthesis Receptors, Adrenergic, beta-3 - genetics Research and analysis methods Rodents Signal Transduction Thermogenesis Uncoupling protein 1 Vascular endothelial growth factor Veterinary colleges Veterinary medicine
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