Baicalin Attenuates IL-17-Mediated Acetaminophen-Induced Liver Injury in a Mouse Model

IL-17 has been shown to be involved in liver inflammatory disorders in both mice and humans. Baicalin (BA), a major compound extracted from traditional herb medicine (Scutellariae radix), has potent hepatoprotective properties. Previous study showed that BA inhibits IL-17-mediated lymphocyte adhesio...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166856
Hauptverfasser:	Liao, Chia-Chih, Day, Yuan-Ji, Lee, Hung-Chen, Liou, Jiin-Tarng, Chou, An-Hsun, Liu, Fu-Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - adverse effects Adhesive joints Alanine Alanine Transaminase - blood Analgesics Analysis Anesthesiology Animal tissues Animals Attenuation Baicalin Biology and Life Sciences Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - pathology Cytokines Disease Models, Animal Flavonoids - pharmacology Flavonoids - therapeutic use Flow Cytometry Hepatitis Hepatology Herbal medicine Hospitals House mouse Immunohistochemistry Inflammation Inflammatory bowel disease Inflammatory diseases Injection Injuries Injury analysis Interleukin 17 Interleukin 6 Interleukin-17 - metabolism Interleukin-6 - metabolism Kinases Laboratory animals Liver Liver - drug effects Liver - metabolism Liver - pathology Liver diseases Liver Regeneration - drug effects Lymphocytes Male Malondialdehyde Malondialdehyde - metabolism Mathematical models Medical research Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Neutrophils Overdose Parameters Peroxidase Peroxidase - metabolism Receptors, Antigen, T-Cell, gamma-delta - metabolism Recruitment Research and Analysis Methods Rodents Superoxide Dismutase - metabolism T cells T-Lymphocytes - drug effects T-Lymphocytes - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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