Bacterially-Associated Transcriptional Remodelling in a Distinct Genomic Subtype of Colorectal Cancer Provides a Plausible Molecular Basis for Disease Development

The relevance of specific microbial colonisation to colorectal cancer (CRC) disease pathogenesis is increasingly recognised, but our understanding of possible underlying molecular mechanisms that may link colonisation to disease in vivo remains limited. Here, we investigate the relationships between...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166282-e0166282
Hauptverfasser:	Lennard, Katie S, Goosen, Ryan W, Blackburn, Jonathan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Bacteria Bacteroides fragilis Bacteroides fragilis - pathogenicity Biology and Life Sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Cancer Cancer genetics Chemokine CXCL10 - biosynthesis Chemokine CXCL10 - genetics Colonization Colony Count, Microbial Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - microbiology Colorectal Neoplasms - pathology Consent CpG islands CpG Islands - genetics CXCL10 protein Deoxyribonucleic acid Development and progression Disease control DNA DNA damage DNA methylation DNA Methylation - genetics E coli Enterococcus faecalis Enterococcus faecalis - pathogenicity Enteropathogenic Escherichia coli - pathogenicity Epithelium Escherichia coli Female Fusobacterium Fusobacterium - pathogenicity Fusobacterium nucleatum Gene expression Gene Expression Regulation, Neoplastic Genes Genetic aspects Genetic research Genomics Host-Pathogen Interactions - genetics Humans In vivo methods and tests Infectious diseases Inflammation Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Lectins, C-Type - biosynthesis Lectins, C-Type - genetics Lithostathine - biosynthesis Lithostathine - genetics Male Medical research Medicine and Health Sciences Methylation Microorganisms Microsatellite Instability Middle Aged Molecular modelling Oxidative stress Pancreatitis-Associated Proteins Pathogenesis Polycomb Repressive Complex 1 - biosynthesis Polycomb Repressive Complex 1 - genetics Stability Stability analysis Studies Transcription Transcription (Genetics) Transcriptome - genetics
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