Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells

In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol. However, at present it is not clear if nAChRs are expressed in enteroendocrine cells oth...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166565
Hauptverfasser:	Qian, Jie, Mummalaneni, Shobha K, Alkahtani, Reem M, Mahavadi, Sunila, Murthy, Karnam S, Grider, John R, Lyall, Vijay
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Alcohol Animals Beta cells Biology and Life Sciences Biophysics Bitter taste Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - antagonists & inhibitors Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - genetics Calcium (intracellular) Calcium - metabolism Cell Line Dihydro-beta-Erythroidine - administration & dosage Enterochromaffin Cells - metabolism Enteroendocrine Cells - metabolism Enzyme-linked immunosorbent assay Ethanol Exposure Gene expression Gene Expression Regulation - drug effects Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestine Mecamylamine Mecamylamine - administration & dosage Mecamylamine - metabolism Medicine and Health Sciences Mice Motility Mucosa Nicotine Nicotine - administration & dosage Nicotine - antagonists & inhibitors Nicotine - metabolism Pancreas Peptides Physical Sciences Physiology Polymerase chain reaction Receptors Receptors, G-Protein-Coupled - biosynthesis Receptors, G-Protein-Coupled - genetics Receptors, Nicotinic - biosynthesis Receptors, Nicotinic - genetics Research and Analysis Methods RNA, Messenger - biosynthesis Social Sciences Studies Taste Taste receptors Taste transduction Time dependence Western blotting
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