Population Density Modulates Drug Inhibition and Gives Rise to Potential Bistability of Treatment Outcomes for Bacterial Infections

The inoculum effect (IE) is an increase in the minimum inhibitory concentration (MIC) of an antibiotic as a function of the initial size of a microbial population. The IE has been observed in a wide range of bacteria, implying that antibiotic efficacy may depend on population density. Such density d...

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Veröffentlicht in:	PLoS computational biology 2016-10, Vol.12 (10), p.e1005098-e1005098
Hauptverfasser:	Karslake, Jason, Maltas, Jeff, Brumm, Peter, Wood, Kevin B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - administration & dosage Antibacterial agents Antibiotics Bacteria Bacterial infections Bacterial Load - drug effects Bacterial Load - physiology Biology and Life Sciences Biophysics Clinical outcomes Colleges & universities Computer Simulation Dosage and administration Dose-Response Relationship, Drug Drug dosages Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - physiology Drug therapy Enterococcus faecalis Enterococcus faecalis - drug effects Enterococcus faecalis - physiology Enzymes Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - microbiology Growth rate Humans Infections Mathematical models Medicine and Health Sciences Microbial Sensitivity Tests - methods Models, Biological Parameter estimation Physical Sciences Population density
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