A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence

Clostridium difficile is a diarrheagenic pathogen associated with significant mortality and morbidity. While its glucosylating toxins are primary virulence determinants, there is increasing appreciation of important roles for non-toxin factors in C. difficile pathogenesis. Cell wall glycopolymers (C...

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Veröffentlicht in:	PLoS pathogens 2016-10, Vol.12 (10), p.e1005946-e1005946
Hauptverfasser:	Chu, Michele, Mallozzi, Michael J G, Roxas, Bryan P, Bertolo, Lisa, Monteiro, Mario A, Agellon, Al, Viswanathan, V K, Vedantam, Gayatri
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Bacteria Bacterial Proteins - metabolism Biology and Life Sciences Biosynthesis Cell Wall - chemistry Cell Wall - ultrastructure Cell walls Clostridium difficile Clostridium difficile - pathogenicity Clostridium difficile - ultrastructure Clostridium Infections - virology Collaboration Colleges & universities Cricetinae Disease Models, Animal Fluorescent Antibody Technique Funding Genes Immunoblotting Inactivation Infections Medicine and Health Sciences Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Mesocricetus Microscopy, Electron Morphology Mortality Mutagenesis, Insertional Mutagenesis, Site-Directed Pathogenesis Pathogens Physiological aspects Polymerase Chain Reaction Polysaccharides Polysaccharides - chemistry Polysaccharides - metabolism Proteins Roles Saccharides Standard deviation Toxins Virulence Virulence (Microbiology) Virulence Factors - metabolism
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