Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets

Tissue damage is usually regarded as a necessary price to pay for successful elimination of pathogens by the innate immune defense. Yet, it is possible to distinguish protective from destructive effects of innate immune activation and selectively attenuate molecular nodes that create pathology. Here...

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Veröffentlicht in:	PLoS pathogens 2016-10, Vol.12 (10), p.e1005848-e1005848
Hauptverfasser:	Ambite, Ines, Puthia, Manoj, Nagy, Karoly, Cafaro, Caterina, Nadeem, Aftab, Butler, Daniel S C, Rydström, Gustav, Filenko, Nina A, Wullt, Björn, Miethke, Thomas, Svanborg, Catharina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Analysis Animals Basic Medicine Binding sites Biology and Life Sciences Biomarkers Bladder Blotting, Western Care and treatment Clinical Medicine Colleges & universities Cystitis Cystitis - genetics Cystitis - immunology Cytokines Disease Models, Animal Disease susceptibility Electrophoretic Mobility Shift Assay Enzyme-Linked Immunosorbent Assay Experiments Female Gene expression Genetic aspects Health aspects Humans Immune system Immunohistochemistry Immunologi inom det medicinska området Immunology Immunology in the medical area Immunoprecipitation Immunotherapy Infections Interleukin-1beta - genetics Interleukin-1beta - immunology Klinisk medicin Laboratories Male Matrix Metalloproteinase 7 - genetics Matrix Metalloproteinase 7 - immunology Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine and Health Sciences Medicinska och farmaceutiska grundvetenskaper Mice Mice, Inbred C57BL Microscopy, Confocal Neutrophils Pathogenesis Pathology Polymerase Chain Reaction Research and Analysis Methods Transcription factors Transcriptome Transfection Urinary bladder Urine Urologi och njurmedicin Urology and Nephrology Web portals
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