Statin Intensity and Clinical Outcome in Patients with Stable Coronary Artery Disease and Very Low LDL-Cholesterol

Although intensive statin therapy is recommended for high risk patients, evidence of its benefit in patients with stable coronary artery disease (CAD) and very low low-density lipoprotein-cholesterol (LDL-C) has been very rare. In this study, we investigated whether higher statin intensity reduces c...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166246-e0166246
Hauptverfasser:	Lee, Soo Youn, Oh, Seung-Jin, Kim, Eung Ju, Oum, Chi-Yoon, Park, Sung Hwan, Oh, Jaewon, Kim, Jung-Sun, Kim, Byeong-Keuk, Park, Sungha, Chang, Hyuk-Jae, Hong, Geu-Ru, Ko, Young-Guk, Kang, Seok-Min, Choi, Donghoon, Ha, Jong-Won, Hong, Myeong-Ki, Jang, Yangsoo, Chung, Namsik, Lee, Sang-Hak
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atorvastatin Atorvastatin Calcium - therapeutic use Blood cholesterol Cardiac patients Cardiology Cardiovascular agents Care and treatment Cholesterol Cholesterol, LDL - blood Cholesterol, VLDL - blood Clinical outcomes Collaboration Confidence intervals Coronary artery Coronary artery bypass Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - drug therapy Coronary heart disease Equivalence Female Health risks Heart Heart diseases Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Incidence Low density lipoprotein Low density lipoproteins Male Medical research Medicine and Health Sciences Patient outcomes Patients People and Places Physicians Proportional Hazards Models Republic of Korea Research and Analysis Methods Retrospective Studies Satellite communications Statins
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Beschreibung
Zusammenfassung:	Although intensive statin therapy is recommended for high risk patients, evidence of its benefit in patients with stable coronary artery disease (CAD) and very low low-density lipoprotein-cholesterol (LDL-C) has been very rare. In this study, we investigated whether higher statin intensity reduces cardiovascular risks in this population. In this retrospective study, a total of 5234 patients with stable CAD were screened at three tertiary hospitals in Korea; 449 patients (mean age: 65 years, male: 69%) with LDL-C
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0166246