Zinc Intake and Risk of Prostate Cancer: Case-Control Study and Meta-Analysis
Zinc is an essential dietary element that has been implicated in the pathogenesis of prostate cancer, a cancer that disproportionately affects men of African descent. Studies assessing the association of zinc intake and prostate cancer have yielded inconsistent results. Furthermore, very little is k...
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| description | Zinc is an essential dietary element that has been implicated in the pathogenesis of prostate cancer, a cancer that disproportionately affects men of African descent. Studies assessing the association of zinc intake and prostate cancer have yielded inconsistent results. Furthermore, very little is known about the relationship between zinc intake and prostate cancer among African Americans. We examined the association between self-reported zinc intake and prostate cancer in a hospital-based case-control study of African Americans. We then compared our results with previous studies by performing a meta-analysis to summarize the evidence regarding the association between zinc and prostate cancer. Newly diagnosed African American men with histologically confirmed prostate cancer (n = 127) and controls (n = 81) were recruited from an urban academic urology clinic in Washington, DC. Controls had higher zinc intake, with a mean of 14 mg/day versus 11 mg/day for cases. We observed a non-significant, non-linear increase in prostate cancer when comparing tertiles of zinc intake (OR |
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Studies assessing the association of zinc intake and prostate cancer have yielded inconsistent results. Furthermore, very little is known about the relationship between zinc intake and prostate cancer among African Americans. We examined the association between self-reported zinc intake and prostate cancer in a hospital-based case-control study of African Americans. We then compared our results with previous studies by performing a meta-analysis to summarize the evidence regarding the association between zinc and prostate cancer. Newly diagnosed African American men with histologically confirmed prostate cancer (n = 127) and controls (n = 81) were recruited from an urban academic urology clinic in Washington, DC. Controls had higher zinc intake, with a mean of 14 mg/day versus 11 mg/day for cases. We observed a non-significant, non-linear increase in prostate cancer when comparing tertiles of zinc intake (OR <6.5 vs 6.5-12.5mg/day 1.8, 95% CI: 0.6,5.6; OR <6.5 vs >12.5mg/day 1.3, 95% CI: 0.2,6.5). The pooled estimate from 17 studies (including 3 cohorts, 2 nested case-control, 11 case-control studies, and 1 randomized clinical trial, with a total of 111,199 participants and 11,689 cases of prostate cancer) was 1.07hi vs lo 95% CI: 0.98-1.16. Using a dose-response meta-analysis, we observed a non-linear trend in the relationship between zinc intake and prostate cancer (p for nonlinearity = 0.0022). This is the first study to examine the relationship between zinc intake in black men and risk of prostate cancer and systematically evaluate available epidemiologic evidence about the magnitude of the relationship between zinc intake and prostate cancer. Despite of the lower intake of zinc by prostate cancer patients, our meta-analysis indicated that there is no evidence for an association between zinc intake and prostate cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0165956</identifier><identifier>PMID: 27824905</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>African Americans ; African Americans - statistics & numerical data ; Biology and Life Sciences ; Cancer ; Cancer research ; Case-Control Studies ; Development and progression ; Diet ; Epidemiology ; Health risk assessment ; Health risks ; Humans ; Male ; Medicine and Health Sciences ; Men ; Meta-analysis ; Minority & ethnic groups ; Nonlinear systems ; Nonlinearity ; Pathogenesis ; People and places ; Physical Sciences ; Prostate - drug effects ; Prostate cancer ; Prostatic Neoplasms - prevention & control ; Research and Analysis Methods ; Risk Factors ; Studies ; Urology ; Vitamin E ; Zinc ; Zinc - therapeutic use</subject><ispartof>PloS one, 2016-11, Vol.11 (11), p.e0165956-e0165956</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Mahmoud et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmoud, Abeer M</au><au>Al-Alem, Umaima</au><au>Dabbous, Firas</au><au>Ali, Mohamed M</au><au>Batai, Ken</au><au>Shah, Ebony</au><au>Kittles, Rick A</au><au>Ahmad, Aamir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc Intake and Risk of Prostate Cancer: Case-Control Study and Meta-Analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-11-08</date><risdate>2016</risdate><volume>11</volume><issue>11</issue><spage>e0165956</spage><epage>e0165956</epage><pages>e0165956-e0165956</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Zinc is an essential dietary element that has been implicated in the pathogenesis of prostate cancer, a cancer that disproportionately affects men of African descent. Studies assessing the association of zinc intake and prostate cancer have yielded inconsistent results. Furthermore, very little is known about the relationship between zinc intake and prostate cancer among African Americans. We examined the association between self-reported zinc intake and prostate cancer in a hospital-based case-control study of African Americans. We then compared our results with previous studies by performing a meta-analysis to summarize the evidence regarding the association between zinc and prostate cancer. Newly diagnosed African American men with histologically confirmed prostate cancer (n = 127) and controls (n = 81) were recruited from an urban academic urology clinic in Washington, DC. Controls had higher zinc intake, with a mean of 14 mg/day versus 11 mg/day for cases. We observed a non-significant, non-linear increase in prostate cancer when comparing tertiles of zinc intake (OR <6.5 vs 6.5-12.5mg/day 1.8, 95% CI: 0.6,5.6; OR <6.5 vs >12.5mg/day 1.3, 95% CI: 0.2,6.5). The pooled estimate from 17 studies (including 3 cohorts, 2 nested case-control, 11 case-control studies, and 1 randomized clinical trial, with a total of 111,199 participants and 11,689 cases of prostate cancer) was 1.07hi vs lo 95% CI: 0.98-1.16. Using a dose-response meta-analysis, we observed a non-linear trend in the relationship between zinc intake and prostate cancer (p for nonlinearity = 0.0022). This is the first study to examine the relationship between zinc intake in black men and risk of prostate cancer and systematically evaluate available epidemiologic evidence about the magnitude of the relationship between zinc intake and prostate cancer. Despite of the lower intake of zinc by prostate cancer patients, our meta-analysis indicated that there is no evidence for an association between zinc intake and prostate cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27824905</pmid><doi>10.1371/journal.pone.0165956</doi><tpages>e0165956</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | African Americans African Americans - statistics & numerical data Biology and Life Sciences Cancer Cancer research Case-Control Studies Development and progression Diet Epidemiology Health risk assessment Health risks Humans Male Medicine and Health Sciences Men Meta-analysis Minority & ethnic groups Nonlinear systems Nonlinearity Pathogenesis People and places Physical Sciences Prostate - drug effects Prostate cancer Prostatic Neoplasms - prevention & control Research and Analysis Methods Risk Factors Studies Urology Vitamin E Zinc Zinc - therapeutic use |
| title | Zinc Intake and Risk of Prostate Cancer: Case-Control Study and Meta-Analysis |
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