CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice

Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report that CCL2 promotes mammary carcinoma development in a clinically relevant murin...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0165595-e0165595
Hauptverfasser:	Chen, Xuguang, Wang, Yunyue, Nelson, David, Tian, Sara, Mulvey, Erin, Patel, Bhumi, Conti, Ilaria, Jaen, Juan, Rollins, Barrett J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal models Animals B cells Biology and Life Sciences Breast cancer Cancer Cancer treatment CC chemokine receptors CCR2 protein Cell Line, Tumor Chemokine CCL2 - deficiency Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokines Disruption Endothelial Progenitor Cells - pathology ErbB-2 protein Female Gene amplification Gene Deletion Gene expression Hospitals Humans Inflammation Kinases Laboratory animals Ligands Mammary gland Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Medicine Medicine and Health Sciences Metastasis Mice Monocyte chemoattractant protein 1 Monocytes Neovascularization Oncology Pharmacology Proteins Receptor, ErbB-2 - metabolism Receptors, CCR2 - antagonists & inhibitors Receptors, CCR2 - deficiency Receptors, CCR2 - genetics Receptors, CCR2 - metabolism Research and Analysis Methods Signaling Survival Tumor Microenvironment Tumors Vascularization Womens health
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