Associations between Nausea, Vomiting, Fatigue and Health-Related Quality of Life of Women in Early Pregnancy: The Generation R Study
The objective of this study was to evaluate the independent associations between nausea, vomiting, fatigue and health-related quality of life of women in early pregnancy in the Generation R study, which is a prospective mother and child cohort. Analyses were based on 5079 women in early pregnancy in...
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| Veröffentlicht in: | PloS one 2016-11, Vol.11 (11), p.e0166133-e0166133 |
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| creator | Bai, Guannan Korfage, Ida J Groen, Esther Hafkamp-de Jaddoe, Vincent W V Mautner, Eva Raat, Hein |
| description | The objective of this study was to evaluate the independent associations between nausea, vomiting, fatigue and health-related quality of life of women in early pregnancy in the Generation R study, which is a prospective mother and child cohort. Analyses were based on 5079 women in early pregnancy in the Rotterdam area, the Netherlands. The information on nausea, vomiting and fatigue in the previous three months was measured in the questionnaire at enrollment, as well as potential confounders (i.e., maternal/gestational age, ethnic background, educational level, parity, marital status, body mass index, tobacco and alcohol use, chronic/infectious conditions, uro-genital conditions/symptoms, sleep quality, headache, anxiety, and depression). Health-related quality of life was assessed by the 12-item Short Form Health Survey and physical and mental component summary scores were calculated. Multivariate regression models were performed to evaluate the independent associations of the presence of nausea, vomiting and fatigue with health-related quality of life, adjusting for potential confounders. 33.6% of women experienced daily presence of nausea, 9.6% for vomiting and 44.4% for fatigue. Comparing with women who never reported nausea, vomiting and fatigue, women with daily presence of at least one of these symptoms had significantly lower scores of physical component summary and mental component summary, after adjusting for potential confounders. Our study shows how common nausea, vomiting and fatigue are among women in early pregnancy and how much each of these symptoms negatively impact on health-related quality of life. We call for awareness of this issue from health care professionals, pregnant women and their families. |
| doi_str_mv | 10.1371/journal.pone.0166133 |
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Analyses were based on 5079 women in early pregnancy in the Rotterdam area, the Netherlands. The information on nausea, vomiting and fatigue in the previous three months was measured in the questionnaire at enrollment, as well as potential confounders (i.e., maternal/gestational age, ethnic background, educational level, parity, marital status, body mass index, tobacco and alcohol use, chronic/infectious conditions, uro-genital conditions/symptoms, sleep quality, headache, anxiety, and depression). Health-related quality of life was assessed by the 12-item Short Form Health Survey and physical and mental component summary scores were calculated. Multivariate regression models were performed to evaluate the independent associations of the presence of nausea, vomiting and fatigue with health-related quality of life, adjusting for potential confounders. 33.6% of women experienced daily presence of nausea, 9.6% for vomiting and 44.4% for fatigue. Comparing with women who never reported nausea, vomiting and fatigue, women with daily presence of at least one of these symptoms had significantly lower scores of physical component summary and mental component summary, after adjusting for potential confounders. Our study shows how common nausea, vomiting and fatigue are among women in early pregnancy and how much each of these symptoms negatively impact on health-related quality of life. We call for awareness of this issue from health care professionals, pregnant women and their families.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0166133</identifier><identifier>PMID: 27814390</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alcoholic beverages ; Analysis ; Anxiety ; Anxiety - etiology ; Biology and Life Sciences ; Body mass ; Body mass index ; Body size ; Depression - etiology ; Fatigue ; Fatigue - etiology ; Female ; Gestational age ; Headache ; Health aspects ; Health care ; Health Surveys - methods ; Humans ; Maternal Age ; Medicine and Health Sciences ; Mental depression ; Mothers ; Nausea ; Nausea - etiology ; Netherlands ; Parity - physiology ; Physical Sciences ; Population ; Pregnancy ; Pregnancy Complications - physiopathology ; Pregnant women ; Prospective Studies ; Public health ; Quality assessment ; Quality of Life ; Questionnaires ; Regression analysis ; Regression models ; Sleep ; Social Sciences ; Studies ; Surveys ; Surveys and Questionnaires ; Tobacco ; Vomiting ; Vomiting - etiology ; Womens health</subject><ispartof>PloS one, 2016-11, Vol.11 (11), p.e0166133-e0166133</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Bai et al. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Bai et al 2016 Bai et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-68bf4717f33ed89bd6e0e3579ab69c9f70b17364b134782b11abff1690008f2f3</citedby><cites>FETCH-LOGICAL-c791t-68bf4717f33ed89bd6e0e3579ab69c9f70b17364b134782b11abff1690008f2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096665/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096665/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27814390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pawluski, Jodi</contributor><creatorcontrib>Bai, Guannan</creatorcontrib><creatorcontrib>Korfage, Ida J</creatorcontrib><creatorcontrib>Groen, Esther Hafkamp-de</creatorcontrib><creatorcontrib>Jaddoe, Vincent W V</creatorcontrib><creatorcontrib>Mautner, Eva</creatorcontrib><creatorcontrib>Raat, Hein</creatorcontrib><title>Associations between Nausea, Vomiting, Fatigue and Health-Related Quality of Life of Women in Early Pregnancy: The Generation R Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The objective of this study was to evaluate the independent associations between nausea, vomiting, fatigue and health-related quality of life of women in early pregnancy in the Generation R study, which is a prospective mother and child cohort. 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Analyses were based on 5079 women in early pregnancy in the Rotterdam area, the Netherlands. The information on nausea, vomiting and fatigue in the previous three months was measured in the questionnaire at enrollment, as well as potential confounders (i.e., maternal/gestational age, ethnic background, educational level, parity, marital status, body mass index, tobacco and alcohol use, chronic/infectious conditions, uro-genital conditions/symptoms, sleep quality, headache, anxiety, and depression). Health-related quality of life was assessed by the 12-item Short Form Health Survey and physical and mental component summary scores were calculated. Multivariate regression models were performed to evaluate the independent associations of the presence of nausea, vomiting and fatigue with health-related quality of life, adjusting for potential confounders. 33.6% of women experienced daily presence of nausea, 9.6% for vomiting and 44.4% for fatigue. Comparing with women who never reported nausea, vomiting and fatigue, women with daily presence of at least one of these symptoms had significantly lower scores of physical component summary and mental component summary, after adjusting for potential confounders. Our study shows how common nausea, vomiting and fatigue are among women in early pregnancy and how much each of these symptoms negatively impact on health-related quality of life. We call for awareness of this issue from health care professionals, pregnant women and their families.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27814390</pmid><doi>10.1371/journal.pone.0166133</doi><tpages>e0166133</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Alcoholic beverages Analysis Anxiety Anxiety - etiology Biology and Life Sciences Body mass Body mass index Body size Depression - etiology Fatigue Fatigue - etiology Female Gestational age Headache Health aspects Health care Health Surveys - methods Humans Maternal Age Medicine and Health Sciences Mental depression Mothers Nausea Nausea - etiology Netherlands Parity - physiology Physical Sciences Population Pregnancy Pregnancy Complications - physiopathology Pregnant women Prospective Studies Public health Quality assessment Quality of Life Questionnaires Regression analysis Regression models Sleep Social Sciences Studies Surveys Surveys and Questionnaires Tobacco Vomiting Vomiting - etiology Womens health |
| title | Associations between Nausea, Vomiting, Fatigue and Health-Related Quality of Life of Women in Early Pregnancy: The Generation R Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T11%3A00%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Associations%20between%20Nausea,%20Vomiting,%20Fatigue%20and%20Health-Related%20Quality%20of%20Life%20of%20Women%20in%20Early%20Pregnancy:%20The%20Generation%20R%20Study&rft.jtitle=PloS%20one&rft.au=Bai,%20Guannan&rft.date=2016-11-04&rft.volume=11&rft.issue=11&rft.spage=e0166133&rft.epage=e0166133&rft.pages=e0166133-e0166133&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0166133&rft_dat=%3Cgale_plos_%3EA471813098%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1836261296&rft_id=info:pmid/27814390&rft_galeid=A471813098&rft_doaj_id=oai_doaj_org_article_59cce748dc8b4a519f632fcdd620ae20&rfr_iscdi=true |