Effect of Diabetes on Survival after Resection of Pancreatic Adenocarcinoma. A Prospective, Observational Study
To investigate the effect of diabetes mellitus (DM) on disease-free and overall post-resection survival of patients with pancreatic ductal adenocarcinoma (PDAC). Prospective observational study on patients admitted for pancreatic disease from January 2008 to October 2012. DM was classified as recent...
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| Veröffentlicht in: | PloS one 2016-11, Vol.11 (11), p.e0166008-e0166008 |
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| creator | Balzano, Gianpaolo Dugnani, Erica Gandolfi, Alessandra Scavini, Marina Pasquale, Valentina Aleotti, Francesca Liberati, Daniela Di Terlizzi, Gaetano Petrella, Giovanna Reni, Michele Doglioni, Claudio Bosi, Emanuele Falconi, Massimo Piemonti, Lorenzo |
| description | To investigate the effect of diabetes mellitus (DM) on disease-free and overall post-resection survival of patients with pancreatic ductal adenocarcinoma (PDAC).
Prospective observational study on patients admitted for pancreatic disease from January 2008 to October 2012. DM was classified as recent-onset ( |
| doi_str_mv | 10.1371/journal.pone.0166008 |
| format | Article |
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Prospective observational study on patients admitted for pancreatic disease from January 2008 to October 2012. DM was classified as recent-onset (<48 months before PDAC diagnosis), longstanding (≥48 months before PDAC) or new onset (after surgery).
Of 296 patients, 140 had a diagnosis of DM prior to surgery (26 longstanding, 99 recent-onset, 15 with unknown duration). Median follow-up time was 5.4 ± 0.22 years. Patients with recent onset DM had poorer postoperative survival than patients without DM: disease-free survival and overall survival were 1.14±0.13 years and 1.52±0.12 years in recent onset DM, versus 1.3±0.15 years and 1.87±0.15 years in non-diabetic patients (p = 0.013 and p = 0.025, respectively). Longstanding DM and postoperative new onset DM had no impact on prognosis. Compared to cases without DM, patients with recent onset DM were more likely to have residual disease after surgery and to develop liver metastases during follow-up. Multivariate analysis confirmed recent onset DM was independently associated with PDAC relapse (hazard ratio 1.45 [1.06-1.99]).
Preoperative recent onset DM has an impact on survival after the resection of PDAC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0166008</identifier><identifier>PMID: 27814399</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenocarcinoma ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Aged ; Analysis ; Biology and Life Sciences ; Cardiovascular disease ; Chemotherapy ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - mortality ; Diabetes Mellitus - physiopathology ; Diabetic neuropathy ; Diabetics ; Diagnosis ; Disease-Free Survival ; Family medical history ; Fasting ; Female ; Glucose ; Health risk assessment ; Hemoglobin ; Hospitals ; Humans ; Insulin resistance ; Liver ; Lymphocytes ; Male ; Malnutrition ; Medical diagnosis ; Medical prognosis ; Medical records ; Medical research ; Medicine and Health Sciences ; Metastases ; Multivariate analysis ; Observational studies ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Patients ; Prognosis ; Prospective Studies ; Risk Factors ; Studies ; Surgery ; Survival ; Systematic review</subject><ispartof>PloS one, 2016-11, Vol.11 (11), p.e0166008-e0166008</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Balzano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Balzano et al 2016 Balzano et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c686t-b7ef7afcb6750bcc1d5959bb50808ed7f20b9a98dceadbdf021de97329b4ee743</citedby><cites>FETCH-LOGICAL-c686t-b7ef7afcb6750bcc1d5959bb50808ed7f20b9a98dceadbdf021de97329b4ee743</cites><orcidid>0000-0002-2172-2198</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096703/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096703/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27814399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balzano, Gianpaolo</creatorcontrib><creatorcontrib>Dugnani, Erica</creatorcontrib><creatorcontrib>Gandolfi, Alessandra</creatorcontrib><creatorcontrib>Scavini, Marina</creatorcontrib><creatorcontrib>Pasquale, Valentina</creatorcontrib><creatorcontrib>Aleotti, Francesca</creatorcontrib><creatorcontrib>Liberati, Daniela</creatorcontrib><creatorcontrib>Di Terlizzi, Gaetano</creatorcontrib><creatorcontrib>Petrella, Giovanna</creatorcontrib><creatorcontrib>Reni, Michele</creatorcontrib><creatorcontrib>Doglioni, Claudio</creatorcontrib><creatorcontrib>Bosi, Emanuele</creatorcontrib><creatorcontrib>Falconi, Massimo</creatorcontrib><creatorcontrib>Piemonti, Lorenzo</creatorcontrib><title>Effect of Diabetes on Survival after Resection of Pancreatic Adenocarcinoma. A Prospective, Observational Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate the effect of diabetes mellitus (DM) on disease-free and overall post-resection survival of patients with pancreatic ductal adenocarcinoma (PDAC).
Prospective observational study on patients admitted for pancreatic disease from January 2008 to October 2012. DM was classified as recent-onset (<48 months before PDAC diagnosis), longstanding (≥48 months before PDAC) or new onset (after surgery).
Of 296 patients, 140 had a diagnosis of DM prior to surgery (26 longstanding, 99 recent-onset, 15 with unknown duration). Median follow-up time was 5.4 ± 0.22 years. Patients with recent onset DM had poorer postoperative survival than patients without DM: disease-free survival and overall survival were 1.14±0.13 years and 1.52±0.12 years in recent onset DM, versus 1.3±0.15 years and 1.87±0.15 years in non-diabetic patients (p = 0.013 and p = 0.025, respectively). Longstanding DM and postoperative new onset DM had no impact on prognosis. Compared to cases without DM, patients with recent onset DM were more likely to have residual disease after surgery and to develop liver metastases during follow-up. Multivariate analysis confirmed recent onset DM was independently associated with PDAC relapse (hazard ratio 1.45 [1.06-1.99]).
Preoperative recent onset DM has an impact on survival after the resection of PDAC.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Aged</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Cardiovascular disease</subject><subject>Chemotherapy</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - mortality</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetic neuropathy</subject><subject>Diabetics</subject><subject>Diagnosis</subject><subject>Disease-Free Survival</subject><subject>Family medical history</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose</subject><subject>Health risk assessment</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Liver</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Metastases</subject><subject>Multivariate analysis</subject><subject>Observational studies</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Surgery</subject><subject>Survival</subject><subject>Systematic review</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkIg0WLHiT9ukKoxoNKkTitwazn2cZsptYudVOzf49BsahEXu7Ll85zX7zn2ybKXGE0xYfjjje-DU-106x1MEaYUIf4oO8WCFBNaIPL4YH-SPYvxBqGKcEqfZicF47gkQpxm_sJa0F3ubf65UTV0EHPv8mUfds1OtbmyHYT8GmKCmhRI3JVyOoDqGp3PDDivVdCN8xs1zWf5VfBxO7A7-JAv6ghhp4bEJLXsenP7PHtiVRvhxbieZT--XHw__za5XHydn88uJ5py2k1qBpYpq2vKKlRrjU0lKlHXFeKIg2G2QLVQghsNytTGogIbEIwUoi4BWEnOstd73W3roxx7FSXmhBYUF5wmYr4njFc3chuajQq30qtG_j3wYSVVSEW2ILWljGIlWMmK0iDGDUcUBAILRgBlSevTeFtfbyCZcl1Q7ZHoccQ1a7nyO1khQRkiSeDdKBD8rx5iJzdN1NC2yoHvB98lJYKTij8AJZQVnDGc0Df_oP9vxEitVKq1cdYni3oQlbOSYY4JxoPD90eU9q6D391K9THK-fL64ezi5zH79oBdg2q7dfRtP3yaeAyWe1CnLxYD2Pv2YiSHibgrTg4TIceJSGmvDp_mPuluBMgfEJQHLw</recordid><startdate>20161104</startdate><enddate>20161104</enddate><creator>Balzano, Gianpaolo</creator><creator>Dugnani, Erica</creator><creator>Gandolfi, Alessandra</creator><creator>Scavini, Marina</creator><creator>Pasquale, Valentina</creator><creator>Aleotti, Francesca</creator><creator>Liberati, Daniela</creator><creator>Di Terlizzi, Gaetano</creator><creator>Petrella, Giovanna</creator><creator>Reni, Michele</creator><creator>Doglioni, Claudio</creator><creator>Bosi, Emanuele</creator><creator>Falconi, Massimo</creator><creator>Piemonti, Lorenzo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2172-2198</orcidid></search><sort><creationdate>20161104</creationdate><title>Effect of Diabetes on Survival after Resection of Pancreatic Adenocarcinoma. A Prospective, Observational Study</title><author>Balzano, Gianpaolo ; Dugnani, Erica ; Gandolfi, Alessandra ; Scavini, Marina ; Pasquale, Valentina ; Aleotti, Francesca ; Liberati, Daniela ; Di Terlizzi, Gaetano ; Petrella, Giovanna ; Reni, Michele ; Doglioni, Claudio ; Bosi, Emanuele ; Falconi, Massimo ; Piemonti, Lorenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c686t-b7ef7afcb6750bcc1d5959bb50808ed7f20b9a98dceadbdf021de97329b4ee743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Aged</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Cardiovascular disease</topic><topic>Chemotherapy</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - mortality</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetic neuropathy</topic><topic>Diabetics</topic><topic>Diagnosis</topic><topic>Disease-Free Survival</topic><topic>Family medical history</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose</topic><topic>Health risk assessment</topic><topic>Hemoglobin</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Liver</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Metastases</topic><topic>Multivariate analysis</topic><topic>Observational studies</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Surgery</topic><topic>Survival</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balzano, Gianpaolo</creatorcontrib><creatorcontrib>Dugnani, Erica</creatorcontrib><creatorcontrib>Gandolfi, Alessandra</creatorcontrib><creatorcontrib>Scavini, Marina</creatorcontrib><creatorcontrib>Pasquale, Valentina</creatorcontrib><creatorcontrib>Aleotti, Francesca</creatorcontrib><creatorcontrib>Liberati, Daniela</creatorcontrib><creatorcontrib>Di Terlizzi, Gaetano</creatorcontrib><creatorcontrib>Petrella, Giovanna</creatorcontrib><creatorcontrib>Reni, Michele</creatorcontrib><creatorcontrib>Doglioni, Claudio</creatorcontrib><creatorcontrib>Bosi, Emanuele</creatorcontrib><creatorcontrib>Falconi, Massimo</creatorcontrib><creatorcontrib>Piemonti, Lorenzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale in Context : Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balzano, Gianpaolo</au><au>Dugnani, Erica</au><au>Gandolfi, Alessandra</au><au>Scavini, Marina</au><au>Pasquale, Valentina</au><au>Aleotti, Francesca</au><au>Liberati, Daniela</au><au>Di Terlizzi, Gaetano</au><au>Petrella, Giovanna</au><au>Reni, Michele</au><au>Doglioni, Claudio</au><au>Bosi, Emanuele</au><au>Falconi, Massimo</au><au>Piemonti, Lorenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Diabetes on Survival after Resection of Pancreatic Adenocarcinoma. A Prospective, Observational Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-11-04</date><risdate>2016</risdate><volume>11</volume><issue>11</issue><spage>e0166008</spage><epage>e0166008</epage><pages>e0166008-e0166008</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To investigate the effect of diabetes mellitus (DM) on disease-free and overall post-resection survival of patients with pancreatic ductal adenocarcinoma (PDAC).
Prospective observational study on patients admitted for pancreatic disease from January 2008 to October 2012. DM was classified as recent-onset (<48 months before PDAC diagnosis), longstanding (≥48 months before PDAC) or new onset (after surgery).
Of 296 patients, 140 had a diagnosis of DM prior to surgery (26 longstanding, 99 recent-onset, 15 with unknown duration). Median follow-up time was 5.4 ± 0.22 years. Patients with recent onset DM had poorer postoperative survival than patients without DM: disease-free survival and overall survival were 1.14±0.13 years and 1.52±0.12 years in recent onset DM, versus 1.3±0.15 years and 1.87±0.15 years in non-diabetic patients (p = 0.013 and p = 0.025, respectively). Longstanding DM and postoperative new onset DM had no impact on prognosis. Compared to cases without DM, patients with recent onset DM were more likely to have residual disease after surgery and to develop liver metastases during follow-up. Multivariate analysis confirmed recent onset DM was independently associated with PDAC relapse (hazard ratio 1.45 [1.06-1.99]).
Preoperative recent onset DM has an impact on survival after the resection of PDAC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27814399</pmid><doi>10.1371/journal.pone.0166008</doi><orcidid>https://orcid.org/0000-0002-2172-2198</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1836261286 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Adenocarcinoma Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Analysis Biology and Life Sciences Cardiovascular disease Chemotherapy Diabetes Diabetes mellitus Diabetes Mellitus - mortality Diabetes Mellitus - physiopathology Diabetic neuropathy Diabetics Diagnosis Disease-Free Survival Family medical history Fasting Female Glucose Health risk assessment Hemoglobin Hospitals Humans Insulin resistance Liver Lymphocytes Male Malnutrition Medical diagnosis Medical prognosis Medical records Medical research Medicine and Health Sciences Metastases Multivariate analysis Observational studies Pancreas Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Patients Prognosis Prospective Studies Risk Factors Studies Surgery Survival Systematic review |
| title | Effect of Diabetes on Survival after Resection of Pancreatic Adenocarcinoma. A Prospective, Observational Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T16%3A42%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Diabetes%20on%20Survival%20after%20Resection%20of%20Pancreatic%20Adenocarcinoma.%20A%20Prospective,%20Observational%20Study&rft.jtitle=PloS%20one&rft.au=Balzano,%20Gianpaolo&rft.date=2016-11-04&rft.volume=11&rft.issue=11&rft.spage=e0166008&rft.epage=e0166008&rft.pages=e0166008-e0166008&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0166008&rft_dat=%3Cgale_plos_%3EA471813113%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1836261286&rft_id=info:pmid/27814399&rft_galeid=A471813113&rft_doaj_id=oai_doaj_org_article_cf6761a974724d078d806e90efed9e67&rfr_iscdi=true |