Living at Higher Altitude and Incidence of Overweight/Obesity: Prospective Analysis of the SUN Cohort
Residence at high altitude has been associated with lower obesity rates probably due to hypoxia conditions. However, there is no evidence of this association in a free-living population. We assessed the association between the altitude where each participant of a Spanish cohort (the SUN Project) was...
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| description | Residence at high altitude has been associated with lower obesity rates probably due to hypoxia conditions. However, there is no evidence of this association in a free-living population.
We assessed the association between the altitude where each participant of a Spanish cohort (the SUN Project) was living and the incidence of overweight/obesity.
The SUN Project is a dynamic, prospective, multipurpose cohort of Spanish university graduates with a retention rate of 89%. We included in the analysis 9 365 participants free of overweight/obesity at baseline. At the baseline questionnaire, participants reported their postal code and the time they had been living in their city/village. We imputed the altitude of each postal code according to the data of the Spanish National Cartographic Institute and categorized participants in tertiles. We used Cox regression models to adjust for potential confounding variables.
During a median follow-up of 10 years, we identified 2 156 incident cases of overweight/obesity. After adjusting for sex, age, time of residence at current city, baseline body mass index, physical activity, sedentarism and years of education (≤ 3 years, ≥ 4 years, Master/PhD), those participants in the third tertile (>456 m) exhibited a statistically significant 14% reduction in the risk of developing overweight/obesity in comparison to those in the first tertile ( |
| doi_str_mv | 10.1371/journal.pone.0164483 |
| format | Article |
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We assessed the association between the altitude where each participant of a Spanish cohort (the SUN Project) was living and the incidence of overweight/obesity.
The SUN Project is a dynamic, prospective, multipurpose cohort of Spanish university graduates with a retention rate of 89%. We included in the analysis 9 365 participants free of overweight/obesity at baseline. At the baseline questionnaire, participants reported their postal code and the time they had been living in their city/village. We imputed the altitude of each postal code according to the data of the Spanish National Cartographic Institute and categorized participants in tertiles. We used Cox regression models to adjust for potential confounding variables.
During a median follow-up of 10 years, we identified 2 156 incident cases of overweight/obesity. After adjusting for sex, age, time of residence at current city, baseline body mass index, physical activity, sedentarism and years of education (≤ 3 years, ≥ 4 years, Master/PhD), those participants in the third tertile (>456 m) exhibited a statistically significant 14% reduction in the risk of developing overweight/obesity in comparison to those in the first tertile (<124 m) (adjusted HR = 0.86; 95% CI: 0.77, 0.96).
Living in cities of higher altitude was inversely associated with the risk of developing overweight/obesity in a cohort of Spanish university graduates.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0164483</identifier><identifier>PMID: 27812092</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Altitude ; Analysis ; Biology and Life Sciences ; Body mass ; Body mass index ; Body size ; Body Weight ; Cartography ; Cohort Studies ; College dropouts ; College graduates ; Colleges & universities ; Cytokines ; Diabetes ; Exercise ; Female ; Graduates ; Health care ; High altitude ; High-altitude environments ; Humans ; Hypoxia ; Incidence ; Male ; Medical research ; Medicine and Health Sciences ; Metabolism ; Nutrition research ; Obesity ; Obesity - epidemiology ; Overweight ; PCB ; People and Places ; Pharmacy ; Physical activity ; Physical Sciences ; Physiology ; Polychlorinated biphenyls ; Population ; Preventive medicine ; Public health ; Regression analysis ; Regression models ; Risk Factors ; Sleep ; Spain - epidemiology ; Statistical analysis ; Studies ; Sun ; Surveys ; Surveys and Questionnaires ; Weight control</subject><ispartof>PloS one, 2016-11, Vol.11 (11), p.e0164483-e0164483</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Díaz-Gutiérrez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Díaz-Gutiérrez et al 2016 Díaz-Gutiérrez et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c795t-607b39fcf6cb0913e9ff5ac50cd8d01421d560e8fa82537605b27ca740a582b63</citedby><cites>FETCH-LOGICAL-c795t-607b39fcf6cb0913e9ff5ac50cd8d01421d560e8fa82537605b27ca740a582b63</cites><orcidid>0000-0003-0351-4018</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094724/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094724/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27812092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Schooling, C. Mary</contributor><creatorcontrib>Díaz-Gutiérrez, Jesús</creatorcontrib><creatorcontrib>Martínez-González, Miguel Ángel</creatorcontrib><creatorcontrib>Pons Izquierdo, Juan José</creatorcontrib><creatorcontrib>González-Muniesa, Pedro</creatorcontrib><creatorcontrib>Martínez, J Alfredo</creatorcontrib><creatorcontrib>Bes-Rastrollo, Maira</creatorcontrib><title>Living at Higher Altitude and Incidence of Overweight/Obesity: Prospective Analysis of the SUN Cohort</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Residence at high altitude has been associated with lower obesity rates probably due to hypoxia conditions. However, there is no evidence of this association in a free-living population.
We assessed the association between the altitude where each participant of a Spanish cohort (the SUN Project) was living and the incidence of overweight/obesity.
The SUN Project is a dynamic, prospective, multipurpose cohort of Spanish university graduates with a retention rate of 89%. We included in the analysis 9 365 participants free of overweight/obesity at baseline. At the baseline questionnaire, participants reported their postal code and the time they had been living in their city/village. We imputed the altitude of each postal code according to the data of the Spanish National Cartographic Institute and categorized participants in tertiles. We used Cox regression models to adjust for potential confounding variables.
During a median follow-up of 10 years, we identified 2 156 incident cases of overweight/obesity. After adjusting for sex, age, time of residence at current city, baseline body mass index, physical activity, sedentarism and years of education (≤ 3 years, ≥ 4 years, Master/PhD), those participants in the third tertile (>456 m) exhibited a statistically significant 14% reduction in the risk of developing overweight/obesity in comparison to those in the first tertile (<124 m) (adjusted HR = 0.86; 95% CI: 0.77, 0.96).
Living in cities of higher altitude was inversely associated with the risk of developing overweight/obesity in a cohort of Spanish university graduates.</description><subject>Adult</subject><subject>Altitude</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body Weight</subject><subject>Cartography</subject><subject>Cohort Studies</subject><subject>College dropouts</subject><subject>College graduates</subject><subject>Colleges & universities</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Exercise</subject><subject>Female</subject><subject>Graduates</subject><subject>Health care</subject><subject>High altitude</subject><subject>High-altitude environments</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Overweight</subject><subject>PCB</subject><subject>People and Places</subject><subject>Pharmacy</subject><subject>Physical activity</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Polychlorinated biphenyls</subject><subject>Population</subject><subject>Preventive medicine</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk Factors</subject><subject>Sleep</subject><subject>Spain - epidemiology</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Sun</subject><subject>Surveys</subject><subject>Surveys and Questionnaires</subject><subject>Weight 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at Higher Altitude and Incidence of Overweight/Obesity: Prospective Analysis of the SUN Cohort</title><author>Díaz-Gutiérrez, Jesús ; Martínez-González, Miguel Ángel ; Pons Izquierdo, Juan José ; González-Muniesa, Pedro ; Martínez, J Alfredo ; Bes-Rastrollo, Maira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c795t-607b39fcf6cb0913e9ff5ac50cd8d01421d560e8fa82537605b27ca740a582b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Altitude</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body Weight</topic><topic>Cartography</topic><topic>Cohort Studies</topic><topic>College dropouts</topic><topic>College graduates</topic><topic>Colleges & universities</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Exercise</topic><topic>Female</topic><topic>Graduates</topic><topic>Health care</topic><topic>High altitude</topic><topic>High-altitude environments</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Overweight</topic><topic>PCB</topic><topic>People and Places</topic><topic>Pharmacy</topic><topic>Physical activity</topic><topic>Physical Sciences</topic><topic>Physiology</topic><topic>Polychlorinated biphenyls</topic><topic>Population</topic><topic>Preventive medicine</topic><topic>Public health</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Risk Factors</topic><topic>Sleep</topic><topic>Spain - epidemiology</topic><topic>Statistical 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Mary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Living at Higher Altitude and Incidence of Overweight/Obesity: Prospective Analysis of the SUN Cohort</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-11-03</date><risdate>2016</risdate><volume>11</volume><issue>11</issue><spage>e0164483</spage><epage>e0164483</epage><pages>e0164483-e0164483</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Residence at high altitude has been associated with lower obesity rates probably due to hypoxia conditions. However, there is no evidence of this association in a free-living population.
We assessed the association between the altitude where each participant of a Spanish cohort (the SUN Project) was living and the incidence of overweight/obesity.
The SUN Project is a dynamic, prospective, multipurpose cohort of Spanish university graduates with a retention rate of 89%. We included in the analysis 9 365 participants free of overweight/obesity at baseline. At the baseline questionnaire, participants reported their postal code and the time they had been living in their city/village. We imputed the altitude of each postal code according to the data of the Spanish National Cartographic Institute and categorized participants in tertiles. We used Cox regression models to adjust for potential confounding variables.
During a median follow-up of 10 years, we identified 2 156 incident cases of overweight/obesity. After adjusting for sex, age, time of residence at current city, baseline body mass index, physical activity, sedentarism and years of education (≤ 3 years, ≥ 4 years, Master/PhD), those participants in the third tertile (>456 m) exhibited a statistically significant 14% reduction in the risk of developing overweight/obesity in comparison to those in the first tertile (<124 m) (adjusted HR = 0.86; 95% CI: 0.77, 0.96).
Living in cities of higher altitude was inversely associated with the risk of developing overweight/obesity in a cohort of Spanish university graduates.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27812092</pmid><doi>10.1371/journal.pone.0164483</doi><tpages>e0164483</tpages><orcidid>https://orcid.org/0000-0003-0351-4018</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-11, Vol.11 (11), p.e0164483-e0164483 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1835969695 |
| source | MEDLINE; Public Library of Science; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adult Altitude Analysis Biology and Life Sciences Body mass Body mass index Body size Body Weight Cartography Cohort Studies College dropouts College graduates Colleges & universities Cytokines Diabetes Exercise Female Graduates Health care High altitude High-altitude environments Humans Hypoxia Incidence Male Medical research Medicine and Health Sciences Metabolism Nutrition research Obesity Obesity - epidemiology Overweight PCB People and Places Pharmacy Physical activity Physical Sciences Physiology Polychlorinated biphenyls Population Preventive medicine Public health Regression analysis Regression models Risk Factors Sleep Spain - epidemiology Statistical analysis Studies Sun Surveys Surveys and Questionnaires Weight control |
| title | Living at Higher Altitude and Incidence of Overweight/Obesity: Prospective Analysis of the SUN Cohort |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T17%3A09%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Living%20at%20Higher%20Altitude%20and%20Incidence%20of%20Overweight/Obesity:%20Prospective%20Analysis%20of%20the%20SUN%20Cohort&rft.jtitle=PloS%20one&rft.au=D%C3%ADaz-Guti%C3%A9rrez,%20Jes%C3%BAs&rft.date=2016-11-03&rft.volume=11&rft.issue=11&rft.spage=e0164483&rft.epage=e0164483&rft.pages=e0164483-e0164483&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0164483&rft_dat=%3Cgale_plos_%3EA471808036%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1835969695&rft_id=info:pmid/27812092&rft_galeid=A471808036&rft_doaj_id=oai_doaj_org_article_d6307ea8ff9d4c0bb360200ca9949f1c&rfr_iscdi=true |