Long-Term Stored Hemoglobin-Vesicles, a Cellular Type of Hemoglobin-Based Oxygen Carrier, Has Resuscitative Effects Comparable to That for Fresh Red Blood Cells in a Rat Model with Massive Hemorrhage without Post-Transfusion Lung Injury

Hemoglobin-vesicles (HbV), encapsulating highly concentrated human hemoglobin in liposomes, were developed as a substitute for red blood cells (RBC) and their safety and efficacy in transfusion therapy has been confirmed in previous studies. Although HbV suspensions are structurally and physicochemi...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0165557-e0165557
Hauptverfasser:	Tokuno, Masahiro, Taguchi, Kazuaki, Yamasaki, Keishi, Sakai, Hiromi, Otagiri, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Acute Lung Injury - etiology Acute Lung Injury - pathology Alveoli Animals Biology and Life Sciences Blood Blood & organ donations Blood cells Blood Gas Analysis Blood Glucose Blood pressure Bronchoalveolar lavage Bronchus Carbon monoxide Comparative analysis Cytokines - metabolism Damage accumulation Disease Models, Animal Edema Erythrocyte Transfusion Erythrocytes Erythrocytes - metabolism Experiments Hematocrit Hemoglobin Hemoglobins Hemoglobins - administration & dosage Hemorrhage Hemorrhage - blood Hemorrhage - complications Hemorrhage - etiology Hemorrhage - therapy Hepatic Insufficiency - etiology Hepatic Insufficiency - metabolism Hepatitis B Hepatitis B virus Inflammation Mediators - metabolism Injuries Kidney Function Tests Kidneys Liposomes Liver Liver Function Tests Lungs Male Mathematical models Medicine and Health Sciences Oxidative Stress Oxygen Oxygen - metabolism Parameters Peroxidase Pharmaceutical sciences Polyethylene glycol Rats Red blood cells Respiratory Function Tests Resuscitation Rodents Shelf life Shock, Hemorrhagic - blood Shock, Hemorrhagic - complications Shock, Hemorrhagic - etiology Shock, Hemorrhagic - therapy Substitutes Survival Rate Transfusion Trauma Treatment Outcome Vesicles
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