Monopolar Detection Thresholds Predict Spatial Selectivity of Neural Excitation in Cochlear Implants: Implications for Speech Recognition
The objectives of the study were to (1) investigate the potential of using monopolar psychophysical detection thresholds for estimating spatial selectivity of neural excitation with cochlear implants and to (2) examine the effect of site removal on speech recognition based on the threshold measure....
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| description | The objectives of the study were to (1) investigate the potential of using monopolar psychophysical detection thresholds for estimating spatial selectivity of neural excitation with cochlear implants and to (2) examine the effect of site removal on speech recognition based on the threshold measure. Detection thresholds were measured in Cochlear Nucleus® device users using monopolar stimulation for pulse trains that were of (a) low rate and long duration, (b) high rate and short duration, and (c) high rate and long duration. Spatial selectivity of neural excitation was estimated by a forward-masking paradigm, where the probe threshold elevation in the presence of a forward masker was measured as a function of masker-probe separation. The strength of the correlation between the monopolar thresholds and the slopes of the masking patterns systematically reduced as neural response of the threshold stimulus involved interpulse interactions (refractoriness and sub-threshold adaptation), and spike-rate adaptation. Detection threshold for the low-rate stimulus most strongly correlated with the spread of forward masking patterns and the correlation reduced for long and high rate pulse trains. The low-rate thresholds were then measured for all electrodes across the array for each subject. Subsequently, speech recognition was tested with experimental maps that deactivated five stimulation sites with the highest thresholds and five randomly chosen ones. Performance with deactivating the high-threshold sites was better than performance with the subjects' clinical map used every day with all electrodes active, in both quiet and background noise. Performance with random deactivation was on average poorer than that with the clinical map but the difference was not significant. These results suggested that the monopolar low-rate thresholds are related to the spatial neural excitation patterns in cochlear implant users and can be used to select sites for more optimal speech recognition performance. |
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Detection thresholds were measured in Cochlear Nucleus® device users using monopolar stimulation for pulse trains that were of (a) low rate and long duration, (b) high rate and short duration, and (c) high rate and long duration. Spatial selectivity of neural excitation was estimated by a forward-masking paradigm, where the probe threshold elevation in the presence of a forward masker was measured as a function of masker-probe separation. The strength of the correlation between the monopolar thresholds and the slopes of the masking patterns systematically reduced as neural response of the threshold stimulus involved interpulse interactions (refractoriness and sub-threshold adaptation), and spike-rate adaptation. Detection threshold for the low-rate stimulus most strongly correlated with the spread of forward masking patterns and the correlation reduced for long and high rate pulse trains. The low-rate thresholds were then measured for all electrodes across the array for each subject. Subsequently, speech recognition was tested with experimental maps that deactivated five stimulation sites with the highest thresholds and five randomly chosen ones. Performance with deactivating the high-threshold sites was better than performance with the subjects' clinical map used every day with all electrodes active, in both quiet and background noise. Performance with random deactivation was on average poorer than that with the clinical map but the difference was not significant. These results suggested that the monopolar low-rate thresholds are related to the spatial neural excitation patterns in cochlear implant users and can be used to select sites for more optimal speech recognition performance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0165476</identifier><identifier>PMID: 27798658</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acoustic Stimulation ; Adaptation ; Adult ; Aged ; Aged, 80 and over ; Auditory Threshold - physiology ; Background noise ; Biology and Life Sciences ; Cochlea ; Cochlear Implants ; Cochlear nuclei ; Correlation ; Deactivation ; Demography ; Ears & hearing ; Electrodes ; Excitation ; Female ; Firing rate ; Humans ; Implants ; Linear Models ; Male ; Masking ; Medicine and Health Sciences ; Middle Aged ; Neurons ; Neurons - physiology ; Noise ; Pathology ; Perceptual Masking ; Physical Sciences ; Psychophysics ; Selectivity ; Social Sciences ; Speech ; Speech - physiology ; Speech recognition ; Stimulation ; Thermal resistance ; Thresholds ; Transplants & implants</subject><ispartof>PloS one, 2016-10, Vol.11 (10), p.e0165476-e0165476</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Ning Zhou. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Subsequently, speech recognition was tested with experimental maps that deactivated five stimulation sites with the highest thresholds and five randomly chosen ones. Performance with deactivating the high-threshold sites was better than performance with the subjects' clinical map used every day with all electrodes active, in both quiet and background noise. Performance with random deactivation was on average poorer than that with the clinical map but the difference was not significant. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Ning</au><au>Zeng, Fan-Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monopolar Detection Thresholds Predict Spatial Selectivity of Neural Excitation in Cochlear Implants: Implications for Speech Recognition</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-10-31</date><risdate>2016</risdate><volume>11</volume><issue>10</issue><spage>e0165476</spage><epage>e0165476</epage><pages>e0165476-e0165476</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The objectives of the study were to (1) investigate the potential of using monopolar psychophysical detection thresholds for estimating spatial selectivity of neural excitation with cochlear implants and to (2) examine the effect of site removal on speech recognition based on the threshold measure. Detection thresholds were measured in Cochlear Nucleus® device users using monopolar stimulation for pulse trains that were of (a) low rate and long duration, (b) high rate and short duration, and (c) high rate and long duration. Spatial selectivity of neural excitation was estimated by a forward-masking paradigm, where the probe threshold elevation in the presence of a forward masker was measured as a function of masker-probe separation. The strength of the correlation between the monopolar thresholds and the slopes of the masking patterns systematically reduced as neural response of the threshold stimulus involved interpulse interactions (refractoriness and sub-threshold adaptation), and spike-rate adaptation. Detection threshold for the low-rate stimulus most strongly correlated with the spread of forward masking patterns and the correlation reduced for long and high rate pulse trains. The low-rate thresholds were then measured for all electrodes across the array for each subject. Subsequently, speech recognition was tested with experimental maps that deactivated five stimulation sites with the highest thresholds and five randomly chosen ones. Performance with deactivating the high-threshold sites was better than performance with the subjects' clinical map used every day with all electrodes active, in both quiet and background noise. Performance with random deactivation was on average poorer than that with the clinical map but the difference was not significant. These results suggested that the monopolar low-rate thresholds are related to the spatial neural excitation patterns in cochlear implant users and can be used to select sites for more optimal speech recognition performance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27798658</pmid><doi>10.1371/journal.pone.0165476</doi><tpages>e0165476</tpages><orcidid>https://orcid.org/0000-0002-9521-679X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acoustic Stimulation Adaptation Adult Aged Aged, 80 and over Auditory Threshold - physiology Background noise Biology and Life Sciences Cochlea Cochlear Implants Cochlear nuclei Correlation Deactivation Demography Ears & hearing Electrodes Excitation Female Firing rate Humans Implants Linear Models Male Masking Medicine and Health Sciences Middle Aged Neurons Neurons - physiology Noise Pathology Perceptual Masking Physical Sciences Psychophysics Selectivity Social Sciences Speech Speech - physiology Speech recognition Stimulation Thermal resistance Thresholds Transplants & implants |
| title | Monopolar Detection Thresholds Predict Spatial Selectivity of Neural Excitation in Cochlear Implants: Implications for Speech Recognition |
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