Perceptions of Research Bronchoscopy in Malawian Adults with Pulmonary Tuberculosis: A Cross-Sectional Study
Bronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological, and microbiological studies. It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity...
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| Veröffentlicht in: | PloS one 2016-10, Vol.11 (10), p.e0165734-e0165734 |
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| creator | McCallum, Andrew D Nyirenda, Deborah Lora, Wezzie Khoo, Saye H Sloan, Derek J Mwandumba, Henry C Desmond, Nicola Davies, Geraint R |
| description | Bronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological, and microbiological studies. It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity alone, and thus informed consent is essential. This study aimed to explore TB patients' understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns, in order to inform consenting processes for future clinical studies. We used a qualitative research design. Two focus group discussions were conducted with community members and TB patients to understand their perceptions of bronchoscopy. Transcripts were coded by multiple co-authors and thematic content analysis was used to analyse main findings. We found that Malawian patients with pulmonary TB were willing to participate in a study using research bronchoscopy for health assessment and access to improved healthcare. We identified information of value to potential participants when consenting to that may lessen some of the anxieties expressed by participants. Patient and public involvement is essential to improve informed consent and institutional trust. |
| doi_str_mv | 10.1371/journal.pone.0165734 |
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It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity alone, and thus informed consent is essential. This study aimed to explore TB patients' understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns, in order to inform consenting processes for future clinical studies. We used a qualitative research design. Two focus group discussions were conducted with community members and TB patients to understand their perceptions of bronchoscopy. Transcripts were coded by multiple co-authors and thematic content analysis was used to analyse main findings. We found that Malawian patients with pulmonary TB were willing to participate in a study using research bronchoscopy for health assessment and access to improved healthcare. We identified information of value to potential participants when consenting to that may lessen some of the anxieties expressed by participants. 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This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 McCallum et al 2016 McCallum et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c795t-85dd33fa20cabe05c70e87f067f20017710c1c05bb48760ccd1a39d6962a2bde3</citedby><cites>FETCH-LOGICAL-c795t-85dd33fa20cabe05c70e87f067f20017710c1c05bb48760ccd1a39d6962a2bde3</cites><orcidid>0000-0003-0814-3834</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085028/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085028/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27792765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Manganelli, Riccardo</contributor><creatorcontrib>McCallum, Andrew D</creatorcontrib><creatorcontrib>Nyirenda, Deborah</creatorcontrib><creatorcontrib>Lora, Wezzie</creatorcontrib><creatorcontrib>Khoo, Saye H</creatorcontrib><creatorcontrib>Sloan, Derek J</creatorcontrib><creatorcontrib>Mwandumba, Henry C</creatorcontrib><creatorcontrib>Desmond, Nicola</creatorcontrib><creatorcontrib>Davies, Geraint R</creatorcontrib><title>Perceptions of Research Bronchoscopy in Malawian Adults with Pulmonary Tuberculosis: A Cross-Sectional Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Bronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological, and microbiological studies. It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity alone, and thus informed consent is essential. This study aimed to explore TB patients' understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns, in order to inform consenting processes for future clinical studies. We used a qualitative research design. Two focus group discussions were conducted with community members and TB patients to understand their perceptions of bronchoscopy. Transcripts were coded by multiple co-authors and thematic content analysis was used to analyse main findings. We found that Malawian patients with pulmonary TB were willing to participate in a study using research bronchoscopy for health assessment and access to improved healthcare. We identified information of value to potential participants when consenting to that may lessen some of the anxieties expressed by participants. Patient and public involvement is essential to improve informed consent and institutional trust.</description><subject>Adult</subject><subject>Adults</subject><subject>Biomedical Research</subject><subject>Bronchoscopy</subject><subject>Clinical medicine</subject><subject>Content analysis</subject><subject>Cross-Sectional Studies</subject><subject>Focus Groups</subject><subject>Health care</subject><subject>Health care reform</subject><subject>Humans</subject><subject>Immunology</subject><subject>Income</subject><subject>Infectious diseases</subject><subject>Informed consent</subject><subject>Low income groups</subject><subject>Malawi</subject><subject>Medical diagnosis</subject><subject>Medical ethics</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Microbiological studies</subject><subject>Motivation</subject><subject>Mycobacterium</subject><subject>Patient Acceptance of Health Care - 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCallum, Andrew D</au><au>Nyirenda, Deborah</au><au>Lora, Wezzie</au><au>Khoo, Saye H</au><au>Sloan, Derek J</au><au>Mwandumba, Henry C</au><au>Desmond, Nicola</au><au>Davies, Geraint R</au><au>Manganelli, Riccardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perceptions of Research Bronchoscopy in Malawian Adults with Pulmonary Tuberculosis: A Cross-Sectional Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-10-28</date><risdate>2016</risdate><volume>11</volume><issue>10</issue><spage>e0165734</spage><epage>e0165734</epage><pages>e0165734-e0165734</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Bronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological, and microbiological studies. It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity alone, and thus informed consent is essential. This study aimed to explore TB patients' understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns, in order to inform consenting processes for future clinical studies. We used a qualitative research design. Two focus group discussions were conducted with community members and TB patients to understand their perceptions of bronchoscopy. Transcripts were coded by multiple co-authors and thematic content analysis was used to analyse main findings. We found that Malawian patients with pulmonary TB were willing to participate in a study using research bronchoscopy for health assessment and access to improved healthcare. We identified information of value to potential participants when consenting to that may lessen some of the anxieties expressed by participants. Patient and public involvement is essential to improve informed consent and institutional trust.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27792765</pmid><doi>10.1371/journal.pone.0165734</doi><tpages>e0165734</tpages><orcidid>https://orcid.org/0000-0003-0814-3834</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adults Biomedical Research Bronchoscopy Clinical medicine Content analysis Cross-Sectional Studies Focus Groups Health care Health care reform Humans Immunology Income Infectious diseases Informed consent Low income groups Malawi Medical diagnosis Medical ethics Medical research Medicine Medicine and Health Sciences Microbiological studies Motivation Mycobacterium Patient Acceptance of Health Care - psychology Patients People and Places Pharmacology Public involvement Qualitative research Research and Analysis Methods Research design Researchers Social sciences Studies Tuberculosis Tuberculosis, Pulmonary Volunteerism Volunteers |
| title | Perceptions of Research Bronchoscopy in Malawian Adults with Pulmonary Tuberculosis: A Cross-Sectional Study |
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