Tumor Necrosis Factor-Alpha and the ERK Pathway Drive Chemerin Expression in Response to Hypoxia in Cultured Human Coronary Artery Endothelial Cells

Chemerin, a novel adipokine, plays a role in the inflammation status of vascular endothelial cells. Hypoxia causes endothelial-cell proliferation, migration, and angiogenesis. This study was aimed at evaluating the protein and mRNA expression of chemerin after exposure of human coronary artery endot...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0165613
Hauptverfasser:	Chua, Su-Kiat, Shyu, Kou-Gi, Lin, Yuh-Feng, Lo, Huey-Ming, Wang, Bao-Wei, Chang, Hang, Lien, Li-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antibodies Biology and Life Sciences Cardiovascular disease Cell adhesion & migration Cell Hypoxia Cell migration Cell Movement Cell Proliferation Cells, Cultured Chemokines - genetics Coronary artery Coronary Vessels - cytology Deoxyribonucleic acid DNA Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Gene expression Gene Expression Regulation Humans Hypoxia Inflammation Intercellular Signaling Peptides and Proteins - genetics Kinases MAP Kinase Signaling System Medicine and Health Sciences Metabolic pathways Necrosis Promoter Regions, Genetic - genetics Protein binding Research and Analysis Methods Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics Rodents siRNA Sp1 protein Sp1 Transcription Factor - metabolism Transcription (Genetics) Transcription, Genetic - drug effects Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors Wu Ho-Su
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