Influence of HLA-DRB1 Alleles on the Variations of Antibody Response to Tuberculosis Serodiagnostic Antigens in Active Tuberculosis Patients
Serology-based tests for tuberculosis (TB) diagnosis, though rapid, efficient and easily implemented, have so far shown unsatisfactory levels of sensitivity and specificity, probably due to variations of the antibody response in TB patients. The number and types of seropositive antigens vary from in...
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| Veröffentlicht in: | PloS one 2016-10, Vol.11 (10), p.e0165291-e0165291 |
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| description | Serology-based tests for tuberculosis (TB) diagnosis, though rapid, efficient and easily implemented, have so far shown unsatisfactory levels of sensitivity and specificity, probably due to variations of the antibody response in TB patients. The number and types of seropositive antigens vary from individual to individual. The person-to-person variations of antigen recognition may be linked to genetic polymorphisms of the human leukocyte antigen (HLA) class II alleles. In the present study, we find that there is a significant increase in the frequency of HLA-DRB1*14 (P = 2.5×10-4) among subjects with high antibody response levels compared to those with low antibody levels. HLA-DRB1*15, the most frequent allelic group in the studied active TB population, positively correlates with subjects with low antibody response levels rather than subjects with high antibody response levels (P = 0.005), which indicates the loss of relevant antigens for screening of patients with this allelic group. The potential association between HLA-DRB1 allelic group and individual antigens implies that TB diagnostic yield could be improved by the addition of antigens screened at the proteome scale in infected subjects from the HLA-DRB1*15 allelic group. |
| doi_str_mv | 10.1371/journal.pone.0165291 |
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The number and types of seropositive antigens vary from individual to individual. The person-to-person variations of antigen recognition may be linked to genetic polymorphisms of the human leukocyte antigen (HLA) class II alleles. In the present study, we find that there is a significant increase in the frequency of HLA-DRB1*14 (P = 2.5×10-4) among subjects with high antibody response levels compared to those with low antibody levels. HLA-DRB1*15, the most frequent allelic group in the studied active TB population, positively correlates with subjects with low antibody response levels rather than subjects with high antibody response levels (P = 0.005), which indicates the loss of relevant antigens for screening of patients with this allelic group. 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The potential association between HLA-DRB1 allelic group and individual antigens implies that TB diagnostic yield could be improved by the addition of antigens screened at the proteome scale in infected subjects from the HLA-DRB1*15 allelic group.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Alleles</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antibody response</subject><subject>Antigens</subject><subject>Biology and Life Sciences</subject><subject>Comparative analysis</subject><subject>Correlation analysis</subject><subject>Diagnostic systems</subject><subject>Drb1 protein</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Hepatitis</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA antigens</subject><subject>HLA-DRB1 Chains - genetics</subject><subject>HLA-DRB1 Chains - 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The number and types of seropositive antigens vary from individual to individual. The person-to-person variations of antigen recognition may be linked to genetic polymorphisms of the human leukocyte antigen (HLA) class II alleles. In the present study, we find that there is a significant increase in the frequency of HLA-DRB1*14 (P = 2.5×10-4) among subjects with high antibody response levels compared to those with low antibody levels. HLA-DRB1*15, the most frequent allelic group in the studied active TB population, positively correlates with subjects with low antibody response levels rather than subjects with high antibody response levels (P = 0.005), which indicates the loss of relevant antigens for screening of patients with this allelic group. The potential association between HLA-DRB1 allelic group and individual antigens implies that TB diagnostic yield could be improved by the addition of antigens screened at the proteome scale in infected subjects from the HLA-DRB1*15 allelic group.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27788190</pmid><doi>10.1371/journal.pone.0165291</doi><tpages>e0165291</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adult AIDS Alleles Antibodies Antibodies, Bacterial - immunology Antibody response Antigens Biology and Life Sciences Comparative analysis Correlation analysis Diagnostic systems Drb1 protein Female Genes Genetic aspects Genetic polymorphisms Hepatitis Histocompatibility antigen HLA HLA antigens HLA-DRB1 Chains - genetics HLA-DRB1 Chains - immunology Humans Immunology Infections Infectious diseases Leukocytes Male Medical diagnosis Medicine Medicine and Health Sciences Middle Aged Mycobacterium Mycobacterium tuberculosis Patients Population studies Proteins Proteomes Serologic Tests Serology Tuberculosis Tuberculosis - diagnosis Tuberculosis - genetics Tuberculosis - immunology Variation |
| title | Influence of HLA-DRB1 Alleles on the Variations of Antibody Response to Tuberculosis Serodiagnostic Antigens in Active Tuberculosis Patients |
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