Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis
Pleural tuberculosis (TB), a form of extrapulmonary TB, can be difficult to diagnose. High numbers of lymphocytes in pleural fluid have been considered part of the diagnostic criteria for pleural TB; however, in many cases, neutrophils rather than lymphocytes are the predominant cell type in pleural...
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| creator | Choi, Hayoung Chon, Hae Ri Kim, Kang Kim, Sukyeon Oh, Ki-Jong Jeong, Suk Hyeon Jung, Woo Jin Shin, Beomsu Jhun, Byung Woo Lee, Hyun Park, Hye Yun Koh, Won-Jung |
| description | Pleural tuberculosis (TB), a form of extrapulmonary TB, can be difficult to diagnose. High numbers of lymphocytes in pleural fluid have been considered part of the diagnostic criteria for pleural TB; however, in many cases, neutrophils rather than lymphocytes are the predominant cell type in pleural effusions, making diagnosis more complicated. Additionally, there is limited information on the clinical and laboratory characteristics of neutrophil-predominant pleural effusions caused by Mycobacterium tuberculosis (MTB). To investigate clinical and laboratory differences between lymphocyte- and neutrophil-predominant pleural TB, we retrospectively analyzed 200 patients with the two types of pleural TB. Of these patients, 9.5% had neutrophil-predominant pleural TB. Patients with lymphocyte-predominant and neutrophil-predominant pleural TB showed similar clinical signs and symptoms. However, neutrophil-predominant pleural TB was associated with significantly higher inflammatory serum markers, such as white blood cell count (P = 0.001) and C-reactive protein (P = 0.001). Moreover, MTB was more frequently detected in the pleural fluid from patients in the neutrophil-predominant group than the lymphocyte-predominant group, with the former group exhibiting significantly higher rates of positive results for acid-fast bacilli in sputum (36.8 versus 9.4%, P = 0.003), diagnostic yield of MTB culture (78.9% versus 22.7%, P < 0.001) and MTB detected by polymerase chain reaction (31.6% versus 5.0%, P = 0.001). Four of seven patients with repeated pleural fluid analyses revealed persistent neutrophil-predominant features, which does not support the traditional viewpoint that neutrophil-predominant pleural TB is a temporary form that rapidly develops into lymphocyte-predominant pleural TB. In conclusion, neutrophil-predominant pleural TB showed a more intense inflammatory response and a higher positive rate in microbiological testing compared to lymphocyte-predominant pleural TB. Pleural TB should be considered in neutrophil-predominant pleural effusions, and microbiological tests are warranted. |
| doi_str_mv | 10.1371/journal.pone.0165428 |
| format | Article |
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High numbers of lymphocytes in pleural fluid have been considered part of the diagnostic criteria for pleural TB; however, in many cases, neutrophils rather than lymphocytes are the predominant cell type in pleural effusions, making diagnosis more complicated. Additionally, there is limited information on the clinical and laboratory characteristics of neutrophil-predominant pleural effusions caused by Mycobacterium tuberculosis (MTB). To investigate clinical and laboratory differences between lymphocyte- and neutrophil-predominant pleural TB, we retrospectively analyzed 200 patients with the two types of pleural TB. Of these patients, 9.5% had neutrophil-predominant pleural TB. Patients with lymphocyte-predominant and neutrophil-predominant pleural TB showed similar clinical signs and symptoms. However, neutrophil-predominant pleural TB was associated with significantly higher inflammatory serum markers, such as white blood cell count (P = 0.001) and C-reactive protein (P = 0.001). Moreover, MTB was more frequently detected in the pleural fluid from patients in the neutrophil-predominant group than the lymphocyte-predominant group, with the former group exhibiting significantly higher rates of positive results for acid-fast bacilli in sputum (36.8 versus 9.4%, P = 0.003), diagnostic yield of MTB culture (78.9% versus 22.7%, P < 0.001) and MTB detected by polymerase chain reaction (31.6% versus 5.0%, P = 0.001). Four of seven patients with repeated pleural fluid analyses revealed persistent neutrophil-predominant features, which does not support the traditional viewpoint that neutrophil-predominant pleural TB is a temporary form that rapidly develops into lymphocyte-predominant pleural TB. In conclusion, neutrophil-predominant pleural TB showed a more intense inflammatory response and a higher positive rate in microbiological testing compared to lymphocyte-predominant pleural TB. Pleural TB should be considered in neutrophil-predominant pleural effusions, and microbiological tests are warranted.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0165428</identifier><identifier>PMID: 27788218</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenosine ; Adult ; Aged ; Aged, 80 and over ; Bacilli ; Biology and Life Sciences ; Biopsy ; C-reactive protein ; Cavitation ; Cell culture ; Critical care ; Diagnostic systems ; Female ; Humans ; Inflammation ; Inflammatory response ; Laboratories ; Leukocytes ; Leukocytes (neutrophilic) ; Lymphocytes ; Lymphocytes - cytology ; Male ; Medical diagnosis ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mycobacterium tuberculosis ; Neutrophils ; Neutrophils - cytology ; Patients ; Pleural Cavity - microbiology ; Pleural fluid ; Polymerase chain reaction ; Signs and symptoms ; Sputum ; Sputum - microbiology ; Tuberculosis ; Tuberculosis, Pleural - diagnosis ; Tuberculosis, Pleural - immunology ; White blood cell count</subject><ispartof>PloS one, 2016-10, Vol.11 (10), p.e0165428-e0165428</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Choi et al 2016 Choi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-4a31c91f07750e640feb89de54801f3a8cc6c4c6612f47031940109513446f4f3</citedby><cites>FETCH-LOGICAL-c725t-4a31c91f07750e640feb89de54801f3a8cc6c4c6612f47031940109513446f4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082823/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082823/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27788218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Subbian, Selvakumar</contributor><creatorcontrib>Choi, Hayoung</creatorcontrib><creatorcontrib>Chon, Hae Ri</creatorcontrib><creatorcontrib>Kim, Kang</creatorcontrib><creatorcontrib>Kim, Sukyeon</creatorcontrib><creatorcontrib>Oh, Ki-Jong</creatorcontrib><creatorcontrib>Jeong, Suk Hyeon</creatorcontrib><creatorcontrib>Jung, Woo Jin</creatorcontrib><creatorcontrib>Shin, Beomsu</creatorcontrib><creatorcontrib>Jhun, Byung Woo</creatorcontrib><creatorcontrib>Lee, Hyun</creatorcontrib><creatorcontrib>Park, Hye Yun</creatorcontrib><creatorcontrib>Koh, Won-Jung</creatorcontrib><title>Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Pleural tuberculosis (TB), a form of extrapulmonary TB, can be difficult to diagnose. High numbers of lymphocytes in pleural fluid have been considered part of the diagnostic criteria for pleural TB; however, in many cases, neutrophils rather than lymphocytes are the predominant cell type in pleural effusions, making diagnosis more complicated. Additionally, there is limited information on the clinical and laboratory characteristics of neutrophil-predominant pleural effusions caused by Mycobacterium tuberculosis (MTB). To investigate clinical and laboratory differences between lymphocyte- and neutrophil-predominant pleural TB, we retrospectively analyzed 200 patients with the two types of pleural TB. Of these patients, 9.5% had neutrophil-predominant pleural TB. Patients with lymphocyte-predominant and neutrophil-predominant pleural TB showed similar clinical signs and symptoms. However, neutrophil-predominant pleural TB was associated with significantly higher inflammatory serum markers, such as white blood cell count (P = 0.001) and C-reactive protein (P = 0.001). Moreover, MTB was more frequently detected in the pleural fluid from patients in the neutrophil-predominant group than the lymphocyte-predominant group, with the former group exhibiting significantly higher rates of positive results for acid-fast bacilli in sputum (36.8 versus 9.4%, P = 0.003), diagnostic yield of MTB culture (78.9% versus 22.7%, P < 0.001) and MTB detected by polymerase chain reaction (31.6% versus 5.0%, P = 0.001). Four of seven patients with repeated pleural fluid analyses revealed persistent neutrophil-predominant features, which does not support the traditional viewpoint that neutrophil-predominant pleural TB is a temporary form that rapidly develops into lymphocyte-predominant pleural TB. In conclusion, neutrophil-predominant pleural TB showed a more intense inflammatory response and a higher positive rate in microbiological testing compared to lymphocyte-predominant pleural TB. Pleural TB should be considered in neutrophil-predominant pleural effusions, and microbiological tests are warranted.</description><subject>Adenosine</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacilli</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>C-reactive protein</subject><subject>Cavitation</subject><subject>Cell culture</subject><subject>Critical care</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Laboratories</subject><subject>Leukocytes</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Lymphocytes - cytology</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis</subject><subject>Neutrophils</subject><subject>Neutrophils - cytology</subject><subject>Patients</subject><subject>Pleural Cavity - microbiology</subject><subject>Pleural fluid</subject><subject>Polymerase chain reaction</subject><subject>Signs and symptoms</subject><subject>Sputum</subject><subject>Sputum - microbiology</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pleural - diagnosis</subject><subject>Tuberculosis, Pleural - immunology</subject><subject>White blood cell count</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0tvEzEQx1cIREvhGyCIhITgkODXer0XpCq8IkW0gsLV8nrHiauNHWwvkG-Pk2yrBPVQ-eCR_Zu_5-EpiucYTTCt8Ltr3wenusnaO5ggzEtGxIPiFNeUjDlB9OGBfVI8ifEaoZIKzh8XJ6SqhCBYnBaLaWed1aobKdeO5qrxQSUfNqMP1hgI4DTEUQPpD4AbzTer9dLrTYLxDv8KfQp-vbTd-DJA61fWKZdGlx30ISte9Q0E3Xc-2vi0eGRUF-HZsJ8VPz59vJp-Gc8vPs-m5_OxrkiZxkxRrGtsUFWVCDhDBhpRt1AygbChSmjNNdOcY2JYhSiuGcKoLjFljBtm6Fnxcq-7zs_KoUZRYkEpJqSsRCZme6L16lqug12psJFeWbk78GEhVUhWdyB5rVHZatCVAWY0aRjn2SQqV7sEvNV6P7zWNyvIpEs58SPR4xtnl3Lhf8sSCSIIzQJvBoHgf_UQk1zZqKHrlAPf7-KuKGY5yfugJReCcpbRV_-hdxdioBYq52qd8TlEvRWV56zCdQ6x3FKTO6i8WlhZnf-esfn8yOHtkUNmEvxNC9XHKGffv92fvfh5zL4-YJegurSMvuuT9S4eg2wP6uBjDGBu-4GR3I7OTTXkdnTkMDrZ7cVhL2-dbmaF_gOrhhNV</recordid><startdate>20161027</startdate><enddate>20161027</enddate><creator>Choi, Hayoung</creator><creator>Chon, Hae Ri</creator><creator>Kim, Kang</creator><creator>Kim, Sukyeon</creator><creator>Oh, Ki-Jong</creator><creator>Jeong, Suk Hyeon</creator><creator>Jung, Woo Jin</creator><creator>Shin, Beomsu</creator><creator>Jhun, Byung Woo</creator><creator>Lee, Hyun</creator><creator>Park, Hye Yun</creator><creator>Koh, Won-Jung</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20161027</creationdate><title>Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis</title><author>Choi, Hayoung ; Chon, Hae Ri ; Kim, Kang ; Kim, Sukyeon ; Oh, Ki-Jong ; Jeong, Suk Hyeon ; Jung, Woo Jin ; Shin, Beomsu ; Jhun, Byung Woo ; Lee, Hyun ; Park, Hye Yun ; Koh, Won-Jung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-4a31c91f07750e640feb89de54801f3a8cc6c4c6612f47031940109513446f4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenosine</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacilli</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>C-reactive protein</topic><topic>Cavitation</topic><topic>Cell culture</topic><topic>Critical care</topic><topic>Diagnostic systems</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Laboratories</topic><topic>Leukocytes</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Lymphocytes - cytology</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis</topic><topic>Neutrophils</topic><topic>Neutrophils - cytology</topic><topic>Patients</topic><topic>Pleural Cavity - microbiology</topic><topic>Pleural fluid</topic><topic>Polymerase chain reaction</topic><topic>Signs and symptoms</topic><topic>Sputum</topic><topic>Sputum - microbiology</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pleural - diagnosis</topic><topic>Tuberculosis, Pleural - immunology</topic><topic>White blood cell count</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Hayoung</creatorcontrib><creatorcontrib>Chon, Hae Ri</creatorcontrib><creatorcontrib>Kim, Kang</creatorcontrib><creatorcontrib>Kim, Sukyeon</creatorcontrib><creatorcontrib>Oh, Ki-Jong</creatorcontrib><creatorcontrib>Jeong, Suk Hyeon</creatorcontrib><creatorcontrib>Jung, Woo Jin</creatorcontrib><creatorcontrib>Shin, Beomsu</creatorcontrib><creatorcontrib>Jhun, Byung Woo</creatorcontrib><creatorcontrib>Lee, Hyun</creatorcontrib><creatorcontrib>Park, Hye Yun</creatorcontrib><creatorcontrib>Koh, Won-Jung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Hayoung</au><au>Chon, Hae Ri</au><au>Kim, Kang</au><au>Kim, Sukyeon</au><au>Oh, Ki-Jong</au><au>Jeong, Suk Hyeon</au><au>Jung, Woo Jin</au><au>Shin, Beomsu</au><au>Jhun, Byung Woo</au><au>Lee, Hyun</au><au>Park, Hye Yun</au><au>Koh, Won-Jung</au><au>Subbian, Selvakumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-10-27</date><risdate>2016</risdate><volume>11</volume><issue>10</issue><spage>e0165428</spage><epage>e0165428</epage><pages>e0165428-e0165428</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Pleural tuberculosis (TB), a form of extrapulmonary TB, can be difficult to diagnose. High numbers of lymphocytes in pleural fluid have been considered part of the diagnostic criteria for pleural TB; however, in many cases, neutrophils rather than lymphocytes are the predominant cell type in pleural effusions, making diagnosis more complicated. Additionally, there is limited information on the clinical and laboratory characteristics of neutrophil-predominant pleural effusions caused by Mycobacterium tuberculosis (MTB). To investigate clinical and laboratory differences between lymphocyte- and neutrophil-predominant pleural TB, we retrospectively analyzed 200 patients with the two types of pleural TB. Of these patients, 9.5% had neutrophil-predominant pleural TB. Patients with lymphocyte-predominant and neutrophil-predominant pleural TB showed similar clinical signs and symptoms. However, neutrophil-predominant pleural TB was associated with significantly higher inflammatory serum markers, such as white blood cell count (P = 0.001) and C-reactive protein (P = 0.001). Moreover, MTB was more frequently detected in the pleural fluid from patients in the neutrophil-predominant group than the lymphocyte-predominant group, with the former group exhibiting significantly higher rates of positive results for acid-fast bacilli in sputum (36.8 versus 9.4%, P = 0.003), diagnostic yield of MTB culture (78.9% versus 22.7%, P < 0.001) and MTB detected by polymerase chain reaction (31.6% versus 5.0%, P = 0.001). Four of seven patients with repeated pleural fluid analyses revealed persistent neutrophil-predominant features, which does not support the traditional viewpoint that neutrophil-predominant pleural TB is a temporary form that rapidly develops into lymphocyte-predominant pleural TB. In conclusion, neutrophil-predominant pleural TB showed a more intense inflammatory response and a higher positive rate in microbiological testing compared to lymphocyte-predominant pleural TB. Pleural TB should be considered in neutrophil-predominant pleural effusions, and microbiological tests are warranted.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27788218</pmid><doi>10.1371/journal.pone.0165428</doi><tpages>e0165428</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-10, Vol.11 (10), p.e0165428-e0165428 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1833122578 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adenosine Adult Aged Aged, 80 and over Bacilli Biology and Life Sciences Biopsy C-reactive protein Cavitation Cell culture Critical care Diagnostic systems Female Humans Inflammation Inflammatory response Laboratories Leukocytes Leukocytes (neutrophilic) Lymphocytes Lymphocytes - cytology Male Medical diagnosis Medicine Medicine and Health Sciences Middle Aged Mycobacterium tuberculosis Neutrophils Neutrophils - cytology Patients Pleural Cavity - microbiology Pleural fluid Polymerase chain reaction Signs and symptoms Sputum Sputum - microbiology Tuberculosis Tuberculosis, Pleural - diagnosis Tuberculosis, Pleural - immunology White blood cell count |
| title | Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T19%3A32%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20and%20Laboratory%20Differences%20between%20Lymphocyte-%20and%20Neutrophil-Predominant%20Pleural%20Tuberculosis&rft.jtitle=PloS%20one&rft.au=Choi,%20Hayoung&rft.date=2016-10-27&rft.volume=11&rft.issue=10&rft.spage=e0165428&rft.epage=e0165428&rft.pages=e0165428-e0165428&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0165428&rft_dat=%3Cgale_plos_%3EA471908258%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1833122578&rft_id=info:pmid/27788218&rft_galeid=A471908258&rft_doaj_id=oai_doaj_org_article_69c05dcec7fe4fc2b4667fe2a1655e18&rfr_iscdi=true |