Supercoiling Effects on Short-Range DNA Looping in E. coli

DNA-protein loops can be essential for gene regulation. The Escherichia coli lactose (lac) operon is controlled by DNA-protein loops that have been studied for decades. Here we adapt this model to test the hypothesis that negative superhelical strain facilitates the formation of short-range (6-8 DNA...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0165306-e0165306
Hauptverfasser:	Mogil, Lauren S, Becker, Nicole A, Maher, 3rd, L James
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibiotics Base pairs Biochemistry Biology and Life Sciences Cell division Deoxyribonucleic acid DNA DNA Gyrase - genetics DNA Gyrase - metabolism DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Bacterial - metabolism DNA, Superhelical - chemistry DNA, Superhelical - genetics DNA, Superhelical - metabolism E coli Electrophoresis, Agar Gel Enzymes Escherichia coli Escherichia coli - genetics Gene expression Gene regulation Genes Genes, Reporter Genetic aspects Genetic research Hypotheses Lac Operon - genetics Lactose Lactose operon Medicine Medicine and Health Sciences Model testing Molecular biology Mutation Nucleic Acid Conformation Proteins Research and Analysis Methods RNA polymerase Supercoiling Superhelical DNA
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