Increased Abundance of Proteins Involved in Resistance to Oxidative and Nitrosative Stress at the Last Stages of Growth and Development of Leishmania amazonensis Promastigotes Revealed by Proteome Analysis

Leishmania amazonensis is one of the major etiological agents of the neglected, stigmatizing disease termed american cutaneous leishmaniasis (ACL). ACL is a zoonosis and rodents are the main reservoirs. Most cases of ACL are reported in Brazil, Bolivia, Colombia and Peru. The biological cycle of the...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164344-e0164344
Hauptverfasser:	Alcolea, Pedro J, Alonso, Ana, García-Tabares, Francisco, Mena, María C, Ciordia, Sergio, Larraga, Vicente
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Arginase Biology and Life Sciences Culture techniques Cutaneous leishmaniasis Dermis Differentiation Electrophoresis, Gel, Two-Dimensional Etiology Gene expression Genomics Growth Hsp70 protein Immunology Iron Leishmania Leishmania - genetics Leishmania - metabolism Leishmania amazonensis Leishmania infantum Leishmania mexicana Leishmaniasis Mammals Nitric oxide Nitrosation Oxidation resistance Oxidative Stress Parasites Parasitic diseases Peroxidase Phagocytes Promastigotes Protein kinase A Protein kinases Proteins Proteolysis Proteome Proteomes Protozoan Proteins - metabolism Pure culture Rodents Signal Transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Superoxide dismutase Tryparedoxin peroxidase Up-Regulation Vector-borne diseases Vectors Zoonoses
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