Deoxyarbutin Possesses a Potent Skin-Lightening Capacity with No Discernible Cytotoxicity against Melanosomes

Safe and effective ingredients capable of removing undesired hyperpigmentation from facial skin are urgently needed for both pharmaceutical and cosmetic purposes. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl) oxy] phenol, D-Arb) is a glucoside derivative of hydroquinone. Here, we investigated the toxi...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0165338
Hauptverfasser:	Miao, Fang, Shi, Ying, Fan, Zhi-Feng, Jiang, Shan, Xu, Shi-Zheng, Lei, Tie-Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Arbutin - analogs & derivatives Arbutin - pharmacology Biocompatibility Biology and Life Sciences Cell Line, Tumor Cosmetics Cytotoxicity Dermatology Drug dosages Electron microscopy Electron paramagnetic resonance Electron spin Electron spin resonance Electron Spin Resonance Spectroscopy Epidemiology Free radicals Guinea Pigs Humidity Hydroquinone Hydroxides Hydroxyl radicals Hyperpigmentation Light Medicine and Health Sciences Melanoma Melanosomes Melanosomes - drug effects Melanosomes - metabolism Membranes Microscopy, Electron, Transmission Outer membranes Phenols Physical Sciences Pigmentation Research and Analysis Methods Skin Skin - drug effects Skin - ultrastructure Skin care Skin Lightening Preparations - pharmacology Skin pigmentation Spin resonance Subcellular Fractions - metabolism Tetrahydro-2H-pyran Topical application Toxicity Transmission electron microscopy
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