Identification and Characterization of VNI/VNII and Novel VNII/VNIV Hybrids and Impact of Hybridization on Virulence and Antifungal Susceptibility Within the C. neoformans/C. gattii Species Complex

Cryptococcus neoformans and C. gattii are pathogenic basidiomycetous yeasts and the commonest cause of fungal infection of the central nervous system. Cryptococci are typically haploid but several inter-species, inter-varietal and intra-varietal hybrids have been reported. It has a bipolar mating sy...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0163955-e0163955
Hauptverfasser:	Aminnejad, Mojgan, Cogliati, Massimo, Duan, Shuyao, Arabatzis, Michael, Tintelnot, Kathrin, Castañeda, Elizabeth, Lazéra, Marcia, Velegraki, Aristea, Ellis, David, Sorrell, Tania C, Meyer, Wieland
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antifungal agents Antifungal Agents - pharmacology Biology and Life Sciences Cell size Central nervous system Cryptococcus Cryptococcus gattii Cryptococcus gattii - genetics Cryptococcus gattii - physiology Cryptococcus neoformans Cryptococcus neoformans - genetics Cryptococcus neoformans - physiology Dilution Fungal infections Fungal Proteins - genetics Fungal Proteins - metabolism Fungicides Galleria mellonella Genes, Mating Type, Fungal - genetics Giant cells Haploidy Health aspects Heterozygosity HIV Human immunodeficiency virus Hybridization Hybridization, Genetic - genetics Hybrids Infections Infectious diseases Laboratories Larvae Lysophospholipase - metabolism Mating Mating types Medical research Medical schools Medicine and Health Sciences Melanin Melanins - metabolism Microbial Sensitivity Tests Morphology Moths Multiplex Polymerase Chain Reaction Mycological Typing Techniques Mycoses Pathogens Phospholipase Physical Sciences Reproduction (biology) Research and Analysis Methods Serogroup Sexual reproduction Species Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Virulence Virulence (Microbiology) Virulence - drug effects Virulence - genetics Virulence factors Virulence Factors - analysis Virulence Factors - genetics Virulence Factors - metabolism Yeasts
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