Multi-Country Evaluation of Safety of Dihydroartemisinin/Piperaquine Post-Licensure in African Public Hospitals with Electrocardiograms

The antimalarial drug piperaquine is associated with delayed ventricular depolarization, causing prolonged QT interval (time taken for ventricular de-polarisation and re-polarisation). There is a lack of safety data regarding dihydroartemisinin/piperaquine (DHA/PPQ) for the treatment of uncomplicate...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164851-e0164851
Hauptverfasser:	Kabanywanyi, Abdunoor M, Baiden, Rita, Ali, Ali M, Mahende, Muhidin K, Ogutu, Bernhards R, Oduro, Abraham, Tinto, Halidou, Gyapong, Margaret, Sie, Ali, Sevene, Esperanca, Macete, Eusebio, Owusu-Agyei, Seth, Adjei, Alex, Compaoré, Guillaume, Valea, Innocent, Osei, Isaac, Yawson, Abena, Adjuik, Martin, Akparibo, Raymond, Kakolwa, Mwaka A, Abdulla, Salim, Binka, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults African Continental Ancestry Group Age Antimalarials - metabolism Antimalarials - pharmacology Antimalarials - therapeutic use Artemisinins - metabolism Artemisinins - pharmacology Artemisinins - therapeutic use Biochemistry Biology and Life Sciences Blood Blood Cell Count Blood Chemical Analysis Burkina Faso Care and treatment Child Child, Preschool Children Clinical trials Data Interpretation, Statistical Depolarization Dihydroartemisinin Drug dosages EKG Electrocardiography Female Ghana Health facilities Heart - diagnostic imaging Heart - drug effects Heart diseases Hospitals Hospitals, Public Humans Intervals Malaria Malaria - drug therapy Male Males Medical research Medicine and Health Sciences Mozambique Patient compliance Patients People and Places Polarization Prolongation Public health Public hospitals Quinolines - metabolism Quinolines - pharmacology Quinolines - therapeutic use Research and Analysis Methods Safety Tanzania Vector-borne diseases Ventricle Ventricular Dysfunction - etiology Young Adult
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