Prevalence of Glomerulopathies in Canine Mammary Carcinoma
The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gl...
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| creator | Crivellenti, Leandro Z Silva, Gyl E B Borin-Crivellenti, Sofia Cianciolo, Rachel Adin, Christopher A Dantas, Márcio Dos Anjos, Denner S Tinucci-Costa, Mirela Santana, Aureo E |
| description | The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy. We evaluated renal biopsies of 32 bitches with spontaneous mammary gland carcinoma and 11 control dogs without mammary gland neoplasia. Samples were obtained from the left kidney and the biopsy material was divided for light microscopy (LM), immunofluorescence (IF) and transmission electron microscopy (TEM). Light microscopy abnormalities were identified in 78.1% of dogs with mammary carcinoma (n = 25) and in none of the dogs in the control group. Focal glomerular mesangial matrix expansion was the most common alteration (n = 15, 60.0%), but mesangial cell proliferation (n = 9, 36.0%) and focal segmental glomerulosclerosis (n = 9, 36.0%), synechiae (n = 7, 28.0%), and globally sclerotic glomeruli (n = 6, 24.0%) were also frequent in dogs with malignancy. Immunofluorescence microscopy revealed strong IgM staining was demonstrated in 64.3% (n = 18) of carcinoma dogs. Transmission electron microscopy from dogs with carcinoma revealed slight changes, the most frequent of which was faint sub-endothelial and mesangial deposits of electron-dense material (78%). Mesangial cell interpositioning and segmental effacement of podocyte foot processes were identified in some specimens (45%). Changes in the glomerulus and proteinuria are common in dogs with naturally occurring mammary carcinoma and this condition appears to provide an excellent large animal model for cancer-associated glomerulopathy in humans. |
| doi_str_mv | 10.1371/journal.pone.0164479 |
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The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy. We evaluated renal biopsies of 32 bitches with spontaneous mammary gland carcinoma and 11 control dogs without mammary gland neoplasia. Samples were obtained from the left kidney and the biopsy material was divided for light microscopy (LM), immunofluorescence (IF) and transmission electron microscopy (TEM). Light microscopy abnormalities were identified in 78.1% of dogs with mammary carcinoma (n = 25) and in none of the dogs in the control group. Focal glomerular mesangial matrix expansion was the most common alteration (n = 15, 60.0%), but mesangial cell proliferation (n = 9, 36.0%) and focal segmental glomerulosclerosis (n = 9, 36.0%), synechiae (n = 7, 28.0%), and globally sclerotic glomeruli (n = 6, 24.0%) were also frequent in dogs with malignancy. Immunofluorescence microscopy revealed strong IgM staining was demonstrated in 64.3% (n = 18) of carcinoma dogs. Transmission electron microscopy from dogs with carcinoma revealed slight changes, the most frequent of which was faint sub-endothelial and mesangial deposits of electron-dense material (78%). Mesangial cell interpositioning and segmental effacement of podocyte foot processes were identified in some specimens (45%). Changes in the glomerulus and proteinuria are common in dogs with naturally occurring mammary carcinoma and this condition appears to provide an excellent large animal model for cancer-associated glomerulopathy in humans.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0164479</identifier><identifier>PMID: 27764139</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Animals ; Biology and Life Sciences ; Biopsy ; Breast cancer ; Cancer ; Carcinoma ; Cell proliferation ; Disease ; Dog Diseases - epidemiology ; Dog Diseases - pathology ; Dogs ; Electron microscopy ; Female ; Glomerular Mesangium - pathology ; Glomerular Mesangium - ultrastructure ; Glomerulonephritis - complications ; Glomerulonephritis - epidemiology ; Glomerulonephritis - pathology ; Glomerulus ; Immunofluorescence ; Immunoglobulin M ; Immunoglobulin M - metabolism ; Kidney - pathology ; Kidney cancer ; Kidney diseases ; Light microscopy ; Malignancy ; Mammary gland ; Mammary Neoplasms, Animal - complications ; Mammary Neoplasms, Animal - pathology ; Medical research ; Medicine and Health Sciences ; Microscopy ; Microscopy, Electron, Transmission ; Microscopy, Fluorescence ; Microscopy, Polarization ; Nephrology ; Pathogenesis ; Pathology ; Prevalence ; Prospective Studies ; Proteinuria ; Proteinuria - complications ; Proteinuria - pathology ; Research and Analysis Methods ; Rodents ; Silva, Sofia ; Surgery ; Transmission electron microscopy ; Tumor removal ; Tumors ; Veterinary colleges ; Veterinary medicine ; Veterinary services</subject><ispartof>PloS one, 2016-10, Vol.11 (10), p.e0164479-e0164479</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Crivellenti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Crivellenti et al 2016 Crivellenti et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-39028d9003a0e7fb201bf201cce2bb349f38e672f76b137a4bd2542e495a13053</citedby><cites>FETCH-LOGICAL-c725t-39028d9003a0e7fb201bf201cce2bb349f38e672f76b137a4bd2542e495a13053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072677/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072677/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27764139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crivellenti, Leandro Z</creatorcontrib><creatorcontrib>Silva, Gyl E B</creatorcontrib><creatorcontrib>Borin-Crivellenti, Sofia</creatorcontrib><creatorcontrib>Cianciolo, Rachel</creatorcontrib><creatorcontrib>Adin, Christopher A</creatorcontrib><creatorcontrib>Dantas, Márcio</creatorcontrib><creatorcontrib>Dos Anjos, Denner S</creatorcontrib><creatorcontrib>Tinucci-Costa, Mirela</creatorcontrib><creatorcontrib>Santana, Aureo E</creatorcontrib><title>Prevalence of Glomerulopathies in Canine Mammary Carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy. We evaluated renal biopsies of 32 bitches with spontaneous mammary gland carcinoma and 11 control dogs without mammary gland neoplasia. Samples were obtained from the left kidney and the biopsy material was divided for light microscopy (LM), immunofluorescence (IF) and transmission electron microscopy (TEM). Light microscopy abnormalities were identified in 78.1% of dogs with mammary carcinoma (n = 25) and in none of the dogs in the control group. Focal glomerular mesangial matrix expansion was the most common alteration (n = 15, 60.0%), but mesangial cell proliferation (n = 9, 36.0%) and focal segmental glomerulosclerosis (n = 9, 36.0%), synechiae (n = 7, 28.0%), and globally sclerotic glomeruli (n = 6, 24.0%) were also frequent in dogs with malignancy. Immunofluorescence microscopy revealed strong IgM staining was demonstrated in 64.3% (n = 18) of carcinoma dogs. Transmission electron microscopy from dogs with carcinoma revealed slight changes, the most frequent of which was faint sub-endothelial and mesangial deposits of electron-dense material (78%). Mesangial cell interpositioning and segmental effacement of podocyte foot processes were identified in some specimens (45%). Changes in the glomerulus and proteinuria are common in dogs with naturally occurring mammary carcinoma and this condition appears to provide an excellent large animal model for cancer-associated glomerulopathy in humans.</description><subject>Abnormalities</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Cell proliferation</subject><subject>Disease</subject><subject>Dog Diseases - epidemiology</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Electron microscopy</subject><subject>Female</subject><subject>Glomerular Mesangium - pathology</subject><subject>Glomerular Mesangium - ultrastructure</subject><subject>Glomerulonephritis - complications</subject><subject>Glomerulonephritis - epidemiology</subject><subject>Glomerulonephritis - 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pathology</subject><subject>Research and Analysis Methods</subject><subject>Rodents</subject><subject>Silva, Sofia</subject><subject>Surgery</subject><subject>Transmission electron microscopy</subject><subject>Tumor removal</subject><subject>Tumors</subject><subject>Veterinary colleges</subject><subject>Veterinary medicine</subject><subject>Veterinary 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E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Glomerulopathies in Canine Mammary Carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-10-20</date><risdate>2016</risdate><volume>11</volume><issue>10</issue><spage>e0164479</spage><epage>e0164479</epage><pages>e0164479-e0164479</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy. We evaluated renal biopsies of 32 bitches with spontaneous mammary gland carcinoma and 11 control dogs without mammary gland neoplasia. Samples were obtained from the left kidney and the biopsy material was divided for light microscopy (LM), immunofluorescence (IF) and transmission electron microscopy (TEM). Light microscopy abnormalities were identified in 78.1% of dogs with mammary carcinoma (n = 25) and in none of the dogs in the control group. Focal glomerular mesangial matrix expansion was the most common alteration (n = 15, 60.0%), but mesangial cell proliferation (n = 9, 36.0%) and focal segmental glomerulosclerosis (n = 9, 36.0%), synechiae (n = 7, 28.0%), and globally sclerotic glomeruli (n = 6, 24.0%) were also frequent in dogs with malignancy. Immunofluorescence microscopy revealed strong IgM staining was demonstrated in 64.3% (n = 18) of carcinoma dogs. Transmission electron microscopy from dogs with carcinoma revealed slight changes, the most frequent of which was faint sub-endothelial and mesangial deposits of electron-dense material (78%). Mesangial cell interpositioning and segmental effacement of podocyte foot processes were identified in some specimens (45%). Changes in the glomerulus and proteinuria are common in dogs with naturally occurring mammary carcinoma and this condition appears to provide an excellent large animal model for cancer-associated glomerulopathy in humans.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27764139</pmid><doi>10.1371/journal.pone.0164479</doi><tpages>e0164479</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1830671286 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Animals Biology and Life Sciences Biopsy Breast cancer Cancer Carcinoma Cell proliferation Disease Dog Diseases - epidemiology Dog Diseases - pathology Dogs Electron microscopy Female Glomerular Mesangium - pathology Glomerular Mesangium - ultrastructure Glomerulonephritis - complications Glomerulonephritis - epidemiology Glomerulonephritis - pathology Glomerulus Immunofluorescence Immunoglobulin M Immunoglobulin M - metabolism Kidney - pathology Kidney cancer Kidney diseases Light microscopy Malignancy Mammary gland Mammary Neoplasms, Animal - complications Mammary Neoplasms, Animal - pathology Medical research Medicine and Health Sciences Microscopy Microscopy, Electron, Transmission Microscopy, Fluorescence Microscopy, Polarization Nephrology Pathogenesis Pathology Prevalence Prospective Studies Proteinuria Proteinuria - complications Proteinuria - pathology Research and Analysis Methods Rodents Silva, Sofia Surgery Transmission electron microscopy Tumor removal Tumors Veterinary colleges Veterinary medicine Veterinary services |
| title | Prevalence of Glomerulopathies in Canine Mammary Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T01%3A45%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20of%20Glomerulopathies%20in%20Canine%20Mammary%20Carcinoma&rft.jtitle=PloS%20one&rft.au=Crivellenti,%20Leandro%20Z&rft.date=2016-10-20&rft.volume=11&rft.issue=10&rft.spage=e0164479&rft.epage=e0164479&rft.pages=e0164479-e0164479&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0164479&rft_dat=%3Cgale_plos_%3EA471891468%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1830671286&rft_id=info:pmid/27764139&rft_galeid=A471891468&rft_doaj_id=oai_doaj_org_article_5f4229c6f5bb49baaa6e471833ef8834&rfr_iscdi=true |