The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells

Ischemia and reperfusion injury may induce apoptosis and lead to sustained tissue damage and loss of function, especially in neuronal organs. While carbon monoxide is known to exert protective effects after various harmful events, the mechanism of carbon monoxide releasing molecules in neuronal tiss...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0165182-e0165182
Hauptverfasser:	Ulbrich, Felix, Kaufmann, Kai B, Meske, Alexander, Lagrèze, Wolf A, Augustynik, Michael, Buerkle, Hartmut, Ramao, Carlos C, Biermann, Julia, Goebel, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anesthesiology Animals Apoptosis Apoptosis - drug effects Attorneys Bax protein Bcl-2 protein bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biology and Life Sciences Brain research Carbon monoxide Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase-3 Cells, Cultured Coordination Complexes - chemistry Coordination Complexes - pharmacology Corms Critical care Diabetic retinopathy Disease Models, Animal Extracellular signal-regulated kinase Female Ganglion cysts Gene expression Imidazoles - pharmacology Immunohistochemistry Injuries Intracellular signalling Ischemia JNK protein Kinases Labeling Laboratory animals Male MAP kinase Medical research Medicine Medicine and Health Sciences Metabolism Mitochondria Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism mRNA Neurons Neuroprotection Neuroprotective Agents - pharmacology Organs p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Physical Sciences Physiology Protein kinases Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Pulmonary arteries Pyridines - pharmacology Rats Rats, Sprague-Dawley Reperfusion Reperfusion injury Reperfusion Injury - metabolism Reperfusion Injury - pathology Research and Analysis Methods Retina Retinal ganglion cells Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology RNA RNA, Messenger - metabolism Rodents Signal Transduction - drug effects
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