Upregulation of HLA Expression in Primary Uveal Melanoma by Infiltrating Leukocytes

Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and increased human leukocyte antigen (HLA) expression, carry an increased risk of death due to metastases. These tumors should be ideal for T-cell based therapies, yet it is not clear why prognostically-inf...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164292-e0164292
Hauptverfasser:	van Essen, T Huibertus, van Pelt, Sake I, Bronkhorst, Inge H G, Versluis, Mieke, Némati, Fariba, Laurent, Cécile, Luyten, Gregorius P M, van Hall, Thorbald, van den Elsen, Peter J, van der Velden, Pieter A, Decaudin, Didier, Jager, Martine J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Antigens Bioinformatics Biology and Life Sciences Cancer Cancer metastasis Chromosome 3 Chromosome 6 Chromosomes Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 6 CIITA protein DNA microarrays Female Gene expression Genes Genetic aspects Genetic factors Histocompatibility antigen HLA HLA antigens HLA Antigens - genetics HLA Antigens - metabolism Humans Immunohistochemistry Implantation Inflammation Interferon regulatory factor 1 Laboratories Leukocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Male Medical prognosis Medicine and Health Sciences Melanoma Melanoma - metabolism Melanoma - pathology Metastases Metastasis Mice Mice, SCID Middle Aged Monosomy Neoplasm Metastasis Patients Peptides - chemistry Peptides - metabolism Phenotypes Polymorphism, Single Nucleotide Regulators Single-nucleotide polymorphism T cells Transcription (Genetics) Transcription factors Transplantation, Heterologous Tumors Up-Regulation Uveal Neoplasms - metabolism Uveal Neoplasms - pathology Xenografts Xenotransplantation
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