Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis
Overexpression of survivin has been reported in many human tumors. However, the clinicopathological features associated with survivin overexpression in cervical carcinoma remain controversial. Thus, the current meta-analysis was performed to assess the clinicopathological significance of survivin in...
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| description | Overexpression of survivin has been reported in many human tumors. However, the clinicopathological features associated with survivin overexpression in cervical carcinoma remain controversial. Thus, the current meta-analysis was performed to assess the clinicopathological significance of survivin in cervical carcinoma.
PubMed, EMBASE, and Web of Science databases were searched for relevant studies published through November 1, 2015. A meta-analysis was performed to evaluate the association between survivin expression and clinicopathological outcome in cervical carcinoma.
Eleven eligible studies with a total of 865 patients were included. Survivin overexpression was closely related to lymph node metastasis (odds ratio [OR] = 0.679, 95% confidence interval [CI]: 0.509-0.905, P = 0.008) but was not significantly associated with tumor FIGO stage (I+II vs. III+IV) (OR = 0.843, 95% CI: 0.626-1.137, P = 0.264), tumor grade (G1+G2 vs. G3) (OR = 0.913, 95% CI: 0.689-1.210, P = 0.527), tumor size (>4 vs. ≤4 cm) (OR = 0.825, 95% CI: 0.434-1.570, P = 0.559), or stromal involvement (OR = 0.820, 95% CI: 0.545-1.233, P = 0.340). The correlation between survivin expression and overall survival was evaluated among a total of 238 patients from three eligible studies. The pooled HR was 1.129 (95% CI: 0.597-1.661; P = 0.000), indicating that survivin expression was significantly associated with poor survival in cervical carcinoma.
Based on the current meta-analysis, survivin is strongly associated with lymph node metastasis and poor prognosis. Additionally, survivin is a novel clinicopathological marker of cervical carcinoma and thus may be a therapeutic target for cervical carcinoma. |
| doi_str_mv | 10.1371/journal.pone.0165117 |
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PubMed, EMBASE, and Web of Science databases were searched for relevant studies published through November 1, 2015. A meta-analysis was performed to evaluate the association between survivin expression and clinicopathological outcome in cervical carcinoma.
Eleven eligible studies with a total of 865 patients were included. Survivin overexpression was closely related to lymph node metastasis (odds ratio [OR] = 0.679, 95% confidence interval [CI]: 0.509-0.905, P = 0.008) but was not significantly associated with tumor FIGO stage (I+II vs. III+IV) (OR = 0.843, 95% CI: 0.626-1.137, P = 0.264), tumor grade (G1+G2 vs. G3) (OR = 0.913, 95% CI: 0.689-1.210, P = 0.527), tumor size (>4 vs. ≤4 cm) (OR = 0.825, 95% CI: 0.434-1.570, P = 0.559), or stromal involvement (OR = 0.820, 95% CI: 0.545-1.233, P = 0.340). The correlation between survivin expression and overall survival was evaluated among a total of 238 patients from three eligible studies. The pooled HR was 1.129 (95% CI: 0.597-1.661; P = 0.000), indicating that survivin expression was significantly associated with poor survival in cervical carcinoma.
Based on the current meta-analysis, survivin is strongly associated with lymph node metastasis and poor prognosis. Additionally, survivin is a novel clinicopathological marker of cervical carcinoma and thus may be a therapeutic target for cervical carcinoma.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0165117</identifier><identifier>PMID: 27764228</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Apoptosis ; Biology and Life Sciences ; Breast cancer ; Cancer metastasis ; Cancer therapies ; Carcinoma ; Cell cycle ; Cell division ; Cervical cancer ; Cervical carcinoma ; Confidence intervals ; Female ; Gene Expression Regulation, Neoplastic ; Gynecology ; Humans ; Inhibitor of Apoptosis Proteins - genetics ; Inhibitor of Apoptosis Proteins - metabolism ; Lymph nodes ; Lymphatic system ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Metastases ; Metastasis ; Neoplasm Metastasis ; Obstetrics ; Online databases ; Patients ; Physical Sciences ; Prognosis ; Research and Analysis Methods ; Squamous cell carcinoma ; Studies ; Survival ; Survival Analysis ; Survivin ; Therapeutic applications ; Thyroid cancer ; Tumors ; Up-Regulation ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - pathology</subject><ispartof>PloS one, 2016-10, Vol.11 (10), p.e0165117-e0165117</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Cheng et al 2016 Cheng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-73314c255c7b306e17a0cb9e6c414be3a769d129f051a19c75ac98fb45d06f193</citedby><cites>FETCH-LOGICAL-c725t-73314c255c7b306e17a0cb9e6c414be3a769d129f051a19c75ac98fb45d06f193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072693/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072693/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27764228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Krieg, Andreas</contributor><creatorcontrib>Cheng, Ke-Yan</creatorcontrib><creatorcontrib>Wang, Zhi-Lian</creatorcontrib><creatorcontrib>Gu, Qian-Yun</creatorcontrib><creatorcontrib>Hao, Min</creatorcontrib><title>Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Overexpression of survivin has been reported in many human tumors. However, the clinicopathological features associated with survivin overexpression in cervical carcinoma remain controversial. Thus, the current meta-analysis was performed to assess the clinicopathological significance of survivin in cervical carcinoma.
PubMed, EMBASE, and Web of Science databases were searched for relevant studies published through November 1, 2015. A meta-analysis was performed to evaluate the association between survivin expression and clinicopathological outcome in cervical carcinoma.
Eleven eligible studies with a total of 865 patients were included. Survivin overexpression was closely related to lymph node metastasis (odds ratio [OR] = 0.679, 95% confidence interval [CI]: 0.509-0.905, P = 0.008) but was not significantly associated with tumor FIGO stage (I+II vs. III+IV) (OR = 0.843, 95% CI: 0.626-1.137, P = 0.264), tumor grade (G1+G2 vs. G3) (OR = 0.913, 95% CI: 0.689-1.210, P = 0.527), tumor size (>4 vs. ≤4 cm) (OR = 0.825, 95% CI: 0.434-1.570, P = 0.559), or stromal involvement (OR = 0.820, 95% CI: 0.545-1.233, P = 0.340). The correlation between survivin expression and overall survival was evaluated among a total of 238 patients from three eligible studies. The pooled HR was 1.129 (95% CI: 0.597-1.661; P = 0.000), indicating that survivin expression was significantly associated with poor survival in cervical carcinoma.
Based on the current meta-analysis, survivin is strongly associated with lymph node metastasis and poor prognosis. Additionally, survivin is a novel clinicopathological marker of cervical carcinoma and thus may be a therapeutic target for cervical carcinoma.</description><subject>Analysis</subject><subject>Apoptosis</subject><subject>Biology and Life Sciences</subject><subject>Breast cancer</subject><subject>Cancer metastasis</subject><subject>Cancer therapies</subject><subject>Carcinoma</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Cervical cancer</subject><subject>Cervical carcinoma</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Inhibitor of Apoptosis Proteins - genetics</subject><subject>Inhibitor of Apoptosis Proteins - metabolism</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neoplasm Metastasis</subject><subject>Obstetrics</subject><subject>Online databases</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Prognosis</subject><subject>Research and Analysis Methods</subject><subject>Squamous cell carcinoma</subject><subject>Studies</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Survivin</subject><subject>Therapeutic applications</subject><subject>Thyroid cancer</subject><subject>Tumors</subject><subject>Up-Regulation</subject><subject>Uterine Cervical Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Ke-Yan</au><au>Wang, Zhi-Lian</au><au>Gu, Qian-Yun</au><au>Hao, Min</au><au>Krieg, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-10-20</date><risdate>2016</risdate><volume>11</volume><issue>10</issue><spage>e0165117</spage><epage>e0165117</epage><pages>e0165117-e0165117</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Overexpression of survivin has been reported in many human tumors. However, the clinicopathological features associated with survivin overexpression in cervical carcinoma remain controversial. Thus, the current meta-analysis was performed to assess the clinicopathological significance of survivin in cervical carcinoma.
PubMed, EMBASE, and Web of Science databases were searched for relevant studies published through November 1, 2015. A meta-analysis was performed to evaluate the association between survivin expression and clinicopathological outcome in cervical carcinoma.
Eleven eligible studies with a total of 865 patients were included. Survivin overexpression was closely related to lymph node metastasis (odds ratio [OR] = 0.679, 95% confidence interval [CI]: 0.509-0.905, P = 0.008) but was not significantly associated with tumor FIGO stage (I+II vs. III+IV) (OR = 0.843, 95% CI: 0.626-1.137, P = 0.264), tumor grade (G1+G2 vs. G3) (OR = 0.913, 95% CI: 0.689-1.210, P = 0.527), tumor size (>4 vs. ≤4 cm) (OR = 0.825, 95% CI: 0.434-1.570, P = 0.559), or stromal involvement (OR = 0.820, 95% CI: 0.545-1.233, P = 0.340). The correlation between survivin expression and overall survival was evaluated among a total of 238 patients from three eligible studies. The pooled HR was 1.129 (95% CI: 0.597-1.661; P = 0.000), indicating that survivin expression was significantly associated with poor survival in cervical carcinoma.
Based on the current meta-analysis, survivin is strongly associated with lymph node metastasis and poor prognosis. Additionally, survivin is a novel clinicopathological marker of cervical carcinoma and thus may be a therapeutic target for cervical carcinoma.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27764228</pmid><doi>10.1371/journal.pone.0165117</doi><tpages>e0165117</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Apoptosis Biology and Life Sciences Breast cancer Cancer metastasis Cancer therapies Carcinoma Cell cycle Cell division Cervical cancer Cervical carcinoma Confidence intervals Female Gene Expression Regulation, Neoplastic Gynecology Humans Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Lymph nodes Lymphatic system Medical research Medicine and Health Sciences Meta-analysis Metastases Metastasis Neoplasm Metastasis Obstetrics Online databases Patients Physical Sciences Prognosis Research and Analysis Methods Squamous cell carcinoma Studies Survival Survival Analysis Survivin Therapeutic applications Thyroid cancer Tumors Up-Regulation Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology |
| title | Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T22%3A39%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Survivin%20Overexpression%20Is%20Associated%20with%20Aggressive%20Clinicopathological%20Features%20in%20Cervical%20Carcinoma:%20A%20Meta-Analysis&rft.jtitle=PloS%20one&rft.au=Cheng,%20Ke-Yan&rft.date=2016-10-20&rft.volume=11&rft.issue=10&rft.spage=e0165117&rft.epage=e0165117&rft.pages=e0165117-e0165117&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0165117&rft_dat=%3Cgale_plos_%3EA471893205%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1830671178&rft_id=info:pmid/27764228&rft_galeid=A471893205&rft_doaj_id=oai_doaj_org_article_5dfb79586c5a40ee991f78a9b831ac39&rfr_iscdi=true |