Recombinant HLA-G as Tolerogenic Immunomodulant in Experimental Small Bowel Transplantation

The non-classical MHC I paralogue HLA-G is expressed by cytotrophoblast cells and implicated with fetomaternal tolerance by downregulating the maternal adaptive and innate immune response against the fetus. HLA-G expression correlates with favorable graft outcome in humans and recently promising imm...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0158907-e0158907
Hauptverfasser:	von Websky, Martin W, Kitamura, Koji, Ludwig-Portugall, Isis, Kurts, Christian, von Laffert, Maximilian, LeMaoult, Joel, Carosella, Edgardo D, Abu-Elmagd, Kareem, Kalff, Joerg C, Schäfer, Nico
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Biology and Life Sciences CD25 antigen CD4 antigen CD8 antigen Contractility Cytometry Fetuses Flow cytometry Foxp3 protein Genetic aspects Graft rejection Graft Rejection - immunology Grafting Health aspects Hematology Histocompatibility antigen HLA HLA antigens HLA-G Antigens - pharmacology Immune response Immune response (cell-mediated) Immune system Immunologic Factors - pharmacology Immunological tolerance Immunology Immunosuppression Infiltration Innate immunity Intestine Intestines - drug effects Intestines - immunology Intestines - transplantation Ischemia Laboratory animals Lymphocytes Lymphocytes T Major histocompatibility complex Male Medicine and Health Sciences Organ transplantation Peroxidase Physiological aspects Populations Rats Recombinant Proteins - pharmacology Research and Analysis Methods Skin Small intestine transplantation Surgery Transplantation Transplantation, Homologous Transplants & implants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!