Testing Danegaptide Effects on Kidney Function after Ischemia/Reperfusion Injury in a New Porcine Two Week Model

Ischemia/reperfusion injury (I/R-I) is a leading cause of acute kidney injury (AKI) and is associated with increased mortality. Danegaptide is a selective modifier of the gap junction protein connexion 43. It has cytoprotective as well as anti-arrhythmic properties and has been shown to reduce the s...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164109-e0164109
Hauptverfasser:	Amdisen, Chris, Keller, Anna K, Hansen, Rie Schultz, Nørregaard, Rikke, Krag, Søren Palmelund, Møldrup, Ulla, Pedersen, Michael, Jespersen, Bente, Birn, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - pharmacology Anti-Arrhythmia Agents - therapeutic use Antiarrhythmia agents Biology and Life Sciences Biomarkers - metabolism Blood Blood flow Clinical medicine Coronary vessels Dipeptides - pharmacology Dipeptides - therapeutic use Disease Models, Animal Excretion Female Gelatinase Glomerular Filtration Rate - drug effects Health aspects Histology Hospitals Infusion Injury prevention Ischemia Kidney - blood supply Kidney - drug effects Kidney - pathology Kidney - physiopathology Kidney diseases Kidneys Kinases Lipocalin Magnetic resonance Magnetic resonance imaging Markers Medical research Medicine Medicine and Health Sciences Myocardial infarction Oxygen - metabolism Pigs Regional Blood Flow - drug effects Renal artery Renal function Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - physiopathology Rodents Studies Surgery Swine Transplants & implants Urine Urology Veins & arteries
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