Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation

Similar to eukaryotic mRNA, the positive-strand coronavirus genome of ~30 kilobases is 5'-capped and 3'-polyadenylated. It has been demonstrated that the length of the coronaviral poly(A) tail is not static but regulated during infection; however, little is known regarding the factors invo...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0165077
Hauptverfasser:	Peng, Yu-Hui, Lin, Ching-Houng, Lin, Chao-Nan, Lo, Chen-Yu, Tsai, Tsung-Lin, Wu, Hung-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and life sciences Cell Line Cloning Coronaviridae Coronavirus - genetics Coronavirus - pathogenicity Coronavirus Infections - virology Coronaviruses COVID-19 Deoxyribonucleic acid DNA Efficiency Gene expression Genetic Variation Genomes Genomics Health aspects Humans Infection Infections Medicine and Health Sciences Messenger RNA mRNA Mutagenesis Mutation Nucleotides Poly(A) Polyadenine Polyadenylation Proteins Research and analysis methods RNA, Messenger - genetics RNA, Viral - genetics Veterinary colleges Veterinary medicine Virology Viruses
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