Sarcopenia as an Independent Risk Factor for Decreased BMD in COPD Patients: Korean National Health and Nutrition Examination Surveys IV and V (2008-2011)

A decrease in bone mineral density (BMD) is a systemic consequence of chronic obstructive pulmonary disease (COPD). Past reports have rarely examined any correlation between sarcopenia and BMD. We investigated the relationship cross-sectionally between the presence of sarcopenia and BMD reduction in...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164303-e0164303
Hauptverfasser:	Lee, Dong-Won, Choi, Eun-Young
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Sprache:	eng
Schlagworte:	Absorptiometry, Photon Age Aged Aging Asian Continental Ancestry Group Biocompatibility Biology and Life Sciences Biomedical materials Body composition Body Mass Index Body weight Bone Density Bone Diseases, Metabolic - complications Bone Diseases, Metabolic - epidemiology Bone mineral density Chronic obstructive lung disease Chronic obstructive pulmonary disease Dual energy X-ray absorptiometry Dyspnea Family medical history Female Femur Femur - diagnostic imaging Femur - physiopathology Health surveys Humans Internal medicine Linear Models Lung - diagnostic imaging Lung - physiology Lung diseases Male Medicine Medicine and Health Sciences Middle Aged Mortality Musculoskeletal system Neck Nutrition Nutrition Surveys Obstructive lung disease Odds Ratio Osteopenia Osteoporosis Osteoporosis - complications Osteoporosis - epidemiology Parathyroid Hormone - blood Patients Physical sciences Polls & surveys Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - pathology Quality of Life Republic of Korea Review boards Risk Factors Sarcopenia Sarcopenia - complications Sarcopenia - epidemiology Spirometry Subgroups Surveys
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description	A decrease in bone mineral density (BMD) is a systemic consequence of chronic obstructive pulmonary disease (COPD). Past reports have rarely examined any correlation between sarcopenia and BMD. We investigated the relationship cross-sectionally between the presence of sarcopenia and BMD reduction in COPD patients. COPD patients aged 50 or older with qualifying spirometry and dual-energy X-ray absorptiometry data were from participants in the Korean National Health and Nutrition Examination Surveys IV and V (2008-2011). There were 286 (33.3%) subjects in the sarcopenia group and 572 (66.7%) in the non-sarcopenia group. The sarcopenia group had lower T-scores than the non-sarcopenia group (femur: -0.73±0.88 vs. -0.18±0.97, p < 0.001; femur neck: -1.44±0.98 vs. -0.99±1.06, p < 0.001; lumbar: -1.38±1.36 vs. -0.84±1.38, p < 0.001). The prevalences of osteopenia and osteoporosis were 60.8% and 22.0%, respectively, in the sarcopenia group and 45.6% and 13.3% in the non-sarcopenia group (both p < 0.001). After adjusting for multiple variables, the presence of sarcopenia associated with increased the risk of osteopenia, osteoporosis, and a low BMD (OR = 3.227, 95% CI = 2.125-4.899, p < 0.001, OR = 6.952, 95% CI = 3.418-14.139, p < 0.001, and OR = 3.495, 95% CI = 2.315-5.278, p < 0.001, respectively). In a subgroup analysis, similar OR changes were confirmed in the high-body-weight group (n = 493) (OR = 2.248, 95% CI = 1.084-4.665, p = 0.030, OR = 4.621, 95% CI = 1.167-18.291, p = 0.029, and OR = 2.376, 95% CI = 1.158-4.877, p = 0.018, respectively). The presence of sarcopenia was associated with increased the risk for decreased BMD in COPD.
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Past reports have rarely examined any correlation between sarcopenia and BMD. We investigated the relationship cross-sectionally between the presence of sarcopenia and BMD reduction in COPD patients. COPD patients aged 50 or older with qualifying spirometry and dual-energy X-ray absorptiometry data were from participants in the Korean National Health and Nutrition Examination Surveys IV and V (2008-2011). There were 286 (33.3%) subjects in the sarcopenia group and 572 (66.7%) in the non-sarcopenia group. The sarcopenia group had lower T-scores than the non-sarcopenia group (femur: -0.73±0.88 vs. -0.18±0.97, p < 0.001; femur neck: -1.44±0.98 vs. -0.99±1.06, p < 0.001; lumbar: -1.38±1.36 vs. -0.84±1.38, p < 0.001). The prevalences of osteopenia and osteoporosis were 60.8% and 22.0%, respectively, in the sarcopenia group and 45.6% and 13.3% in the non-sarcopenia group (both p < 0.001). After adjusting for multiple variables, the presence of sarcopenia associated with increased the risk of osteopenia, osteoporosis, and a low BMD (OR = 3.227, 95% CI = 2.125-4.899, p < 0.001, OR = 6.952, 95% CI = 3.418-14.139, p < 0.001, and OR = 3.495, 95% CI = 2.315-5.278, p < 0.001, respectively). In a subgroup analysis, similar OR changes were confirmed in the high-body-weight group (n = 493) (OR = 2.248, 95% CI = 1.084-4.665, p = 0.030, OR = 4.621, 95% CI = 1.167-18.291, p = 0.029, and OR = 2.376, 95% CI = 1.158-4.877, p = 0.018, respectively). The presence of sarcopenia was associated with increased the risk for decreased BMD in COPD.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0164303</identifier><identifier>PMID: 27749901</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Absorptiometry, Photon ; Age ; Aged ; Aging ; Asian Continental Ancestry Group ; Biocompatibility ; Biology and Life Sciences ; Biomedical materials ; Body composition ; Body Mass Index ; Body weight ; Bone Density ; Bone Diseases, Metabolic - complications ; Bone Diseases, Metabolic - epidemiology ; Bone mineral density ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Dual energy X-ray absorptiometry ; Dyspnea ; Family medical history ; Female ; Femur ; Femur - diagnostic imaging ; Femur - physiopathology ; Health surveys ; Humans ; Internal medicine ; Linear Models ; Lung - diagnostic imaging ; Lung - physiology ; Lung diseases ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Musculoskeletal system ; Neck ; Nutrition ; Nutrition Surveys ; Obstructive lung disease ; Odds Ratio ; Osteopenia ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis - epidemiology ; Parathyroid Hormone - blood ; Patients ; Physical sciences ; Polls & surveys ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - pathology ; Quality of Life ; Republic of Korea ; Review boards ; Risk Factors ; Sarcopenia ; Sarcopenia - complications ; Sarcopenia - epidemiology ; Spirometry ; Subgroups ; Surveys</subject><ispartof>PloS one, 2016-10, Vol.11 (10), p.e0164303-e0164303</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Lee, Choi. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Lee, Choi 2016 Lee, Choi</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-9739342853d42a5212dfe430698e756faaf07c87c903282f08d9e0396e1797493</citedby><cites>FETCH-LOGICAL-c791t-9739342853d42a5212dfe430698e756faaf07c87c903282f08d9e0396e1797493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066961/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066961/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27749901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Dong-Won</creatorcontrib><creatorcontrib>Choi, Eun-Young</creatorcontrib><title>Sarcopenia as an Independent Risk Factor for Decreased BMD in COPD Patients: Korean National Health and Nutrition Examination Surveys IV and V (2008-2011)</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[A decrease in bone mineral density (BMD) is a systemic consequence of chronic obstructive pulmonary disease (COPD). Past reports have rarely examined any correlation between sarcopenia and BMD. We investigated the relationship cross-sectionally between the presence of sarcopenia and BMD reduction in COPD patients. COPD patients aged 50 or older with qualifying spirometry and dual-energy X-ray absorptiometry data were from participants in the Korean National Health and Nutrition Examination Surveys IV and V (2008-2011). There were 286 (33.3%) subjects in the sarcopenia group and 572 (66.7%) in the non-sarcopenia group. The sarcopenia group had lower T-scores than the non-sarcopenia group (femur: -0.73±0.88 vs. -0.18±0.97, p < 0.001; femur neck: -1.44±0.98 vs. -0.99±1.06, p < 0.001; lumbar: -1.38±1.36 vs. -0.84±1.38, p < 0.001). The prevalences of osteopenia and osteoporosis were 60.8% and 22.0%, respectively, in the sarcopenia group and 45.6% and 13.3% in the non-sarcopenia group (both p < 0.001). After adjusting for multiple variables, the presence of sarcopenia associated with increased the risk of osteopenia, osteoporosis, and a low BMD (OR = 3.227, 95% CI = 2.125-4.899, p < 0.001, OR = 6.952, 95% CI = 3.418-14.139, p < 0.001, and OR = 3.495, 95% CI = 2.315-5.278, p < 0.001, respectively). In a subgroup analysis, similar OR changes were confirmed in the high-body-weight group (n = 493) (OR = 2.248, 95% CI = 1.084-4.665, p = 0.030, OR = 4.621, 95% CI = 1.167-18.291, p = 0.029, and OR = 2.376, 95% CI = 1.158-4.877, p = 0.018, respectively). The presence of sarcopenia was associated with increased the risk for decreased BMD in COPD.]]></description><subject>Absorptiometry, Photon</subject><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Asian Continental Ancestry Group</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Biomedical materials</subject><subject>Body composition</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Bone Density</subject><subject>Bone Diseases, Metabolic - complications</subject><subject>Bone Diseases, Metabolic - epidemiology</subject><subject>Bone mineral density</subject><subject>Chronic obstructive lung disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Dyspnea</subject><subject>Family medical history</subject><subject>Female</subject><subject>Femur</subject><subject>Femur - diagnostic imaging</subject><subject>Femur - physiopathology</subject><subject>Health surveys</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Linear Models</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - physiology</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Musculoskeletal system</subject><subject>Neck</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Obstructive lung disease</subject><subject>Odds Ratio</subject><subject>Osteopenia</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - epidemiology</subject><subject>Parathyroid Hormone - blood</subject><subject>Patients</subject><subject>Physical sciences</subject><subject>Polls & surveys</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Dong-Won</au><au>Choi, Eun-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sarcopenia as an Independent Risk Factor for Decreased BMD in COPD Patients: Korean National Health and Nutrition Examination Surveys IV and V (2008-2011)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-10-17</date><risdate>2016</risdate><volume>11</volume><issue>10</issue><spage>e0164303</spage><epage>e0164303</epage><pages>e0164303-e0164303</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[A decrease in bone mineral density (BMD) is a systemic consequence of chronic obstructive pulmonary disease (COPD). Past reports have rarely examined any correlation between sarcopenia and BMD. We investigated the relationship cross-sectionally between the presence of sarcopenia and BMD reduction in COPD patients. COPD patients aged 50 or older with qualifying spirometry and dual-energy X-ray absorptiometry data were from participants in the Korean National Health and Nutrition Examination Surveys IV and V (2008-2011). There were 286 (33.3%) subjects in the sarcopenia group and 572 (66.7%) in the non-sarcopenia group. The sarcopenia group had lower T-scores than the non-sarcopenia group (femur: -0.73±0.88 vs. -0.18±0.97, p < 0.001; femur neck: -1.44±0.98 vs. -0.99±1.06, p < 0.001; lumbar: -1.38±1.36 vs. -0.84±1.38, p < 0.001). The prevalences of osteopenia and osteoporosis were 60.8% and 22.0%, respectively, in the sarcopenia group and 45.6% and 13.3% in the non-sarcopenia group (both p < 0.001). After adjusting for multiple variables, the presence of sarcopenia associated with increased the risk of osteopenia, osteoporosis, and a low BMD (OR = 3.227, 95% CI = 2.125-4.899, p < 0.001, OR = 6.952, 95% CI = 3.418-14.139, p < 0.001, and OR = 3.495, 95% CI = 2.315-5.278, p < 0.001, respectively). In a subgroup analysis, similar OR changes were confirmed in the high-body-weight group (n = 493) (OR = 2.248, 95% CI = 1.084-4.665, p = 0.030, OR = 4.621, 95% CI = 1.167-18.291, p = 0.029, and OR = 2.376, 95% CI = 1.158-4.877, p = 0.018, respectively). The presence of sarcopenia was associated with increased the risk for decreased BMD in COPD.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27749901</pmid><doi>10.1371/journal.pone.0164303</doi><tpages>e0164303</tpages><oa>free_for_read</oa></addata></record>
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subjects	Absorptiometry, Photon Age Aged Aging Asian Continental Ancestry Group Biocompatibility Biology and Life Sciences Biomedical materials Body composition Body Mass Index Body weight Bone Density Bone Diseases, Metabolic - complications Bone Diseases, Metabolic - epidemiology Bone mineral density Chronic obstructive lung disease Chronic obstructive pulmonary disease Dual energy X-ray absorptiometry Dyspnea Family medical history Female Femur Femur - diagnostic imaging Femur - physiopathology Health surveys Humans Internal medicine Linear Models Lung - diagnostic imaging Lung - physiology Lung diseases Male Medicine Medicine and Health Sciences Middle Aged Mortality Musculoskeletal system Neck Nutrition Nutrition Surveys Obstructive lung disease Odds Ratio Osteopenia Osteoporosis Osteoporosis - complications Osteoporosis - epidemiology Parathyroid Hormone - blood Patients Physical sciences Polls & surveys Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - pathology Quality of Life Republic of Korea Review boards Risk Factors Sarcopenia Sarcopenia - complications Sarcopenia - epidemiology Spirometry Subgroups Surveys
title	Sarcopenia as an Independent Risk Factor for Decreased BMD in COPD Patients: Korean National Health and Nutrition Examination Surveys IV and V (2008-2011)
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