Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans

The translation initiation factor eIF3 is a multi-subunit protein complex that coordinates the assembly of the 43S pre-initiation complex in eukaryotes. Prior studies have demonstrated that not all subunits of eIF3 are essential for the initiation of translation, suggesting that some subunits may se...

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Veröffentlicht in:	PLoS genetics 2016-09, Vol.12 (9), p.e1006326-e1006326
Hauptverfasser:	Cattie, Douglas J, Richardson, Claire E, Reddy, Kirthi C, Ness-Cohn, Elan M, Droste, Rita, Thompson, Mary K, Gilbert, Wendy V, Kim, Dennis H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - genetics Aging - genetics Animals Animals, Genetically Modified Biology Biology and Life Sciences Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Colleges & universities Deoxyribonucleic acid DNA Endoplasmic reticulum Endoplasmic Reticulum Stress - genetics Eukaryotic Initiation Factor-3 - genetics Funding Gene mutation Genes Genetic aspects Homeostasis Longevity - genetics Medicine and Health Sciences Microtubule-Associated Proteins - genetics Mutation Nematodes Observations Physiological aspects Physiology Protein synthesis Proteins Regulation Research and Analysis Methods Roles Stress, Physiological - genetics
Online-Zugang:	Volltext
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