DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and differentiation. Prior work established doublesex- and mab-3-related transcription factor 1 (Dmrt1) as a conserved transcriptional regulator...

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Veröffentlicht in:	PLoS genetics 2016-09, Vol.12 (9), p.e1006293-e1006293
Hauptverfasser:	Zhang, Teng, Oatley, Jon, Bardwell, Vivian J, Zarkower, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biology and Life Sciences Cell interactions Colleges & universities Deoxyribonucleic acid Developmental biology DNA Experiments Funding Genetics Homeostasis Inhibitor of Differentiation Proteins - genetics Inhibitor of Differentiation Proteins - metabolism Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Male Mammals Medicine and Health Sciences Mice Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Observations Physiological aspects Population Promyelocytic Leukemia Zinc Finger Protein Research and analysis methods Rodents Sperm Spermatogenesis Spermatogenesis - genetics Spermatogonia - cytology Spermatogonia - metabolism Stem cells Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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