Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment

Herpes simplex virus 1 (HSV-1) establishes latency in trigeminal ganglia (TG) sensory neurons of infected individuals. The commitment of infected neurons toward the viral lytic or latent transcriptional program is likely to depend on both viral and cellular factors, and to differ among individual ne...

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Veröffentlicht in:	PLoS pathogens 2016-09, Vol.12 (9), p.e1005834-e1005834
Hauptverfasser:	Maroui, Mohamed Ali, Callé, Aleth, Cohen, Camille, Streichenberger, Nathalie, Texier, Pascale, Takissian, Julie, Rousseau, Antoine, Poccardi, Nolwenn, Welsch, Jérémy, Corpet, Armelle, Schaeffer, Laurent, Labetoulle, Marc, Lomonte, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquisitions & mergers Analysis Animals Biochemistry, Molecular Biology Biology and Life Sciences Carrier Proteins - genetics Carrier Proteins - metabolism Deoxyribonucleic acid DNA Female Genetic aspects Genome, Viral - genetics Genomes Genomics Health aspects Herpes Simplex - virology Herpes simplex virus Herpes viruses Herpesviridae Herpesvirus 1, Human - genetics Herpesvirus 1, Human - physiology Human health and pathology Humans Immunology Infections Infectious diseases Innate immunity Interferon Type I - genetics Interferon Type I - metabolism Kinases Leukemia Life Sciences Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Knockout Microbiology and Parasitology Mutation Neurons Promyelocytic Leukemia Protein - genetics Promyelocytic Leukemia Protein - metabolism Proteins Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - metabolism Signal Transduction Studies Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Trigeminal Ganglion - virology Virology Virulence (Microbiology) Virus Latency - genetics
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