Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts

In rheumatoid arthritis (RA), synovial fibroblasts (RA-SFs) accumulate in affected joints, where they play roles in inflammation and joint destruction. RA-SFs exhibit tumor-like proliferation and are resistant to apoptosis. Although RA-SF activation is well described, negative regulators of RA-SF ac...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164350-e0164350
Hauptverfasser:	Morinobu, Akio, Tanaka, Shino, Nishimura, Keisuke, Takahashi, Soshi, Kageyama, Goichi, Miura, Yasushi, Kurosaka, Masahiro, Saegusa, Jun, Kumagai, Shunichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Amino acids Analysis Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Arthritis Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Biocompatibility Biology and Life Sciences Biomedical materials Bone surgery Cancer Cells, Cultured Chemokines Chemokines - genetics Chemokines - metabolism Cytokines Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene expression Genes Genetic aspects Histone deacetylase Hospitals Humans Hydroxamic Acids - pharmacology IL-1β Immune response Immunology Inflammation Ionizing radiation Joint diseases Laboratories Lipopolysaccharides Medical prognosis Medical research Medicine Medicine and Health Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mitogens Monoclonal antibodies mRNA Orthopedics Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - pathology Pathogenesis Polymerase chain reaction Regulators Rheumatoid arthritis Rheumatoid factor Rheumatology Ribonucleic acid RNA Studies Surgery Synovial Membrane - cytology Synovial Membrane - drug effects Synovial Membrane - metabolism Trichostatin A Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Tumorigenesis University graduates Up-Regulation Western blotting
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