Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity

Organ formation is achieved through the complex interplay between signaling pathways and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles during embryonic development including patterning, proliferation and differentiation in distinct tissues. Previous studies have...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164714-e0164714
Hauptverfasser:	Muñoz-Bravo, Jose Luis, Flores-Martínez, Alvaro, Herrero-Martin, Griselda, Puri, Sapna, Taketo, Makoto Mark, Rojas, Anabel, Hebrok, Matthias, Cano, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activation Animal experimentation Animal tissues Animals beta Catenin - genetics beta Catenin - metabolism Biology and Life Sciences Cascades Developmental plasticity Diabetes Embryo, Mammalian - metabolism Embryo, Mammalian - surgery Embryogenesis Embryonic development Embryonic growth stage Epithelium Epithelium - metabolism Gastroenterology Genes Hedgehog protein Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homeostasis Hospitals Hypoplasia Intestine Intestines - metabolism Medicine and Health Sciences Mesenchyme Mesoderm - metabolism Mice Mice, Transgenic Oligonucleotide Array Sequence Analysis Pancreas Pancreas - metabolism Pancreas - pathology Pancreas - surgery Pathways Pattern formation Rodents Signal transduction Signaling Stomach - metabolism Studies Trans-Activators - genetics Trans-Activators - metabolism Transcription Wnt protein Wnt Proteins - metabolism Wnt Signaling Pathway
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