Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
To allow early diagnosis and monitoring of disease progression, there is a need for biomarkers in amyotrophic lateral sclerosis (ALS). Neurofilaments (NF) are emerging protein biomarkers in other neurological diseases, and are of possible use in ALS. The aim of this study is to evaluate the utility...
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| description | To allow early diagnosis and monitoring of disease progression, there is a need for biomarkers in amyotrophic lateral sclerosis (ALS). Neurofilaments (NF) are emerging protein biomarkers in other neurological diseases, and are of possible use in ALS.
The aim of this study is to evaluate the utility of NF levels as blood or cerebrospinal fluid (CSF) biomarker in patients with ALS.
A systematic search of Pubmed, Embase and Scopus was performed. Methodological quality assessment was applied to refine the final search results. Meta-analysis of the data was performed.
Level of NF heavy chain and light chains were significantly elevated in the CSF of ALS patients compared to healthy controls/controls without parenchymal central nervous system (CNS) involvement and ALS mimic disease patients. NF light chain level in CSF was higher in ALS patients than in neurological patients with CNS involvement (SMD = 1.352, P = 0.01). NF light chain concentration in blood was higher in ALS patients than healthy controls/controls without CNS involvement (SMD = 1.448, P |
| doi_str_mv | 10.1371/journal.pone.0164625 |
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The aim of this study is to evaluate the utility of NF levels as blood or cerebrospinal fluid (CSF) biomarker in patients with ALS.
A systematic search of Pubmed, Embase and Scopus was performed. Methodological quality assessment was applied to refine the final search results. Meta-analysis of the data was performed.
Level of NF heavy chain and light chains were significantly elevated in the CSF of ALS patients compared to healthy controls/controls without parenchymal central nervous system (CNS) involvement and ALS mimic disease patients. NF light chain level in CSF was higher in ALS patients than in neurological patients with CNS involvement (SMD = 1.352, P = 0.01). NF light chain concentration in blood was higher in ALS patients than healthy controls/controls without CNS involvement (SMD = 1.448, P<0.0001). NF heavy chain levels in CSF were negatively correlated disease duration and ALSFRS-R ((r = -0.447, P<0.0001; r = -0.486, P<0.0001). NF light chain levels in CSF were negatively correlated with disease duration (r = -0.273, P = 0.011).
NF heavy and light chain levels have potential use as a marker of neural degeneration in ALS, but are not specific for the disease, and are more likely to be used as measures of disease progression.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0164625</identifier><identifier>PMID: 27732645</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - blood ; Amyotrophic Lateral Sclerosis - cerebrospinal fluid ; Amyotrophic Lateral Sclerosis - diagnosis ; Amyotrophic Lateral Sclerosis - pathology ; Analysis ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Biomarkers - cerebrospinal fluid ; Blood ; Blood levels ; Brain research ; Central nervous system ; Cerebrospinal fluid ; Chains ; Data processing ; Degeneration ; Dementia ; Development and progression ; Disease Progression ; Fluids ; Humans ; Intermediate filament proteins ; Light chains ; Light levels ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Metabolism ; Methods ; Multiple sclerosis ; Nervous system ; Nervous system diseases ; Neurodegeneration ; Neurofilament Proteins - blood ; Neurofilament Proteins - cerebrospinal fluid ; Neurofilaments ; Neurological diseases ; Neurology ; Neurosciences ; Patients ; Physical Sciences ; Proteins ; Quality ; Quality assessment ; Quality control ; Research and Analysis Methods ; Studies ; Systematic review</subject><ispartof>PloS one, 2016-10, Vol.11 (10), p.e0164625-e0164625</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Xu et al 2016 Xu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-916617e48abf23a94176018da8bcf53f6cf67d4a88da5f1a89ba7637826be2993</citedby><cites>FETCH-LOGICAL-c725t-916617e48abf23a94176018da8bcf53f6cf67d4a88da5f1a89ba7637826be2993</cites><orcidid>0000-0001-5735-9987</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061412/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061412/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27732645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Zhouwei</creatorcontrib><creatorcontrib>Henderson, Robert David</creatorcontrib><creatorcontrib>David, Michael</creatorcontrib><creatorcontrib>McCombe, Pamela Ann</creatorcontrib><title>Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To allow early diagnosis and monitoring of disease progression, there is a need for biomarkers in amyotrophic lateral sclerosis (ALS). Neurofilaments (NF) are emerging protein biomarkers in other neurological diseases, and are of possible use in ALS.
The aim of this study is to evaluate the utility of NF levels as blood or cerebrospinal fluid (CSF) biomarker in patients with ALS.
A systematic search of Pubmed, Embase and Scopus was performed. Methodological quality assessment was applied to refine the final search results. Meta-analysis of the data was performed.
Level of NF heavy chain and light chains were significantly elevated in the CSF of ALS patients compared to healthy controls/controls without parenchymal central nervous system (CNS) involvement and ALS mimic disease patients. NF light chain level in CSF was higher in ALS patients than in neurological patients with CNS involvement (SMD = 1.352, P = 0.01). NF light chain concentration in blood was higher in ALS patients than healthy controls/controls without CNS involvement (SMD = 1.448, P<0.0001). NF heavy chain levels in CSF were negatively correlated disease duration and ALSFRS-R ((r = -0.447, P<0.0001; r = -0.486, P<0.0001). NF light chain levels in CSF were negatively correlated with disease duration (r = -0.273, P = 0.011).
NF heavy and light chain levels have potential use as a marker of neural degeneration in ALS, but are not specific for the disease, and are more likely to be used as measures of disease progression.</description><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - blood</subject><subject>Amyotrophic Lateral Sclerosis - cerebrospinal fluid</subject><subject>Amyotrophic Lateral Sclerosis - diagnosis</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Analysis</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Brain research</subject><subject>Central nervous system</subject><subject>Cerebrospinal fluid</subject><subject>Chains</subject><subject>Data processing</subject><subject>Degeneration</subject><subject>Dementia</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Fluids</subject><subject>Humans</subject><subject>Intermediate filament proteins</subject><subject>Light chains</subject><subject>Light levels</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metabolism</subject><subject>Methods</subject><subject>Multiple sclerosis</subject><subject>Nervous system</subject><subject>Nervous system diseases</subject><subject>Neurodegeneration</subject><subject>Neurofilament Proteins - blood</subject><subject>Neurofilament Proteins - cerebrospinal fluid</subject><subject>Neurofilaments</subject><subject>Neurological diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Proteins</subject><subject>Quality</subject><subject>Quality assessment</subject><subject>Quality control</subject><subject>Research and Analysis Methods</subject><subject>Studies</subject><subject>Systematic review</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkJw0WLHie3sAqlMfFQqTFqBW-skOW49krjYyaD_HnfNpgbtYvKFLfs5r89nFD2nZEqZoO8ube9aqKcb2-KUUJ7yJHsQHdOcJROeEPbw4HwUPfH-kpCMSc4fR0eJECzhaXYc4TfsndWmhgbbzsfg4w_GNuB-ofOxti6eNVvbObtZmzJeQIcO6nhZ1uisN_40nsXLre-wgS68X-CVwT8xtFX8FTuYzIKD24A9jR5pqD0-G_aT6Menj9_PvkwW55_nZ7PFpBRJ1k1yyjkVmEoodMIgT6nghMoKZFHqjGleai6qFGS4yjQFmRcgOBMy4QUmec5Oopd73U1tvRoy5BWViaSCZowHYr4nKguXauNMCHWrLBh1fWHdSoELodSowm9BP7ghCaa0koUmRYE8xwwqAkwHrffDb33RYFWGBIbkjETHL61Zq5W9UhnhNKVJEHgzCDj7u0ffqcb4EusaWrT9zm8mGMk4z-6DZimV8lr11X_o3YkYqBWEWE2rQ5Gh3ImqWSqo5CT0U6Cmd1BhVdiYMnRe6BwcG7wdGQSmw7_dCnrv1Xx5cX_2_OeYfX3ArhHqbu1t3XfGtn4MpnuwDA3qHerbelCidoNzkw21Gxw1DE4we3FYy1ujm0lh_wCVYBNB</recordid><startdate>20161012</startdate><enddate>20161012</enddate><creator>Xu, Zhouwei</creator><creator>Henderson, Robert David</creator><creator>David, Michael</creator><creator>McCombe, Pamela Ann</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5735-9987</orcidid></search><sort><creationdate>20161012</creationdate><title>Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis</title><author>Xu, Zhouwei ; Henderson, Robert David ; David, Michael ; McCombe, Pamela Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-916617e48abf23a94176018da8bcf53f6cf67d4a88da5f1a89ba7637826be2993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Zhouwei</au><au>Henderson, Robert David</au><au>David, Michael</au><au>McCombe, Pamela Ann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-10-12</date><risdate>2016</risdate><volume>11</volume><issue>10</issue><spage>e0164625</spage><epage>e0164625</epage><pages>e0164625-e0164625</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To allow early diagnosis and monitoring of disease progression, there is a need for biomarkers in amyotrophic lateral sclerosis (ALS). Neurofilaments (NF) are emerging protein biomarkers in other neurological diseases, and are of possible use in ALS.
The aim of this study is to evaluate the utility of NF levels as blood or cerebrospinal fluid (CSF) biomarker in patients with ALS.
A systematic search of Pubmed, Embase and Scopus was performed. Methodological quality assessment was applied to refine the final search results. Meta-analysis of the data was performed.
Level of NF heavy chain and light chains were significantly elevated in the CSF of ALS patients compared to healthy controls/controls without parenchymal central nervous system (CNS) involvement and ALS mimic disease patients. NF light chain level in CSF was higher in ALS patients than in neurological patients with CNS involvement (SMD = 1.352, P = 0.01). NF light chain concentration in blood was higher in ALS patients than healthy controls/controls without CNS involvement (SMD = 1.448, P<0.0001). NF heavy chain levels in CSF were negatively correlated disease duration and ALSFRS-R ((r = -0.447, P<0.0001; r = -0.486, P<0.0001). NF light chain levels in CSF were negatively correlated with disease duration (r = -0.273, P = 0.011).
NF heavy and light chain levels have potential use as a marker of neural degeneration in ALS, but are not specific for the disease, and are more likely to be used as measures of disease progression.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27732645</pmid><doi>10.1371/journal.pone.0164625</doi><tpages>e0164625</tpages><orcidid>https://orcid.org/0000-0001-5735-9987</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - cerebrospinal fluid Amyotrophic Lateral Sclerosis - diagnosis Amyotrophic Lateral Sclerosis - pathology Analysis Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Biomarkers - cerebrospinal fluid Blood Blood levels Brain research Central nervous system Cerebrospinal fluid Chains Data processing Degeneration Dementia Development and progression Disease Progression Fluids Humans Intermediate filament proteins Light chains Light levels Medical prognosis Medical research Medicine and Health Sciences Meta-analysis Metabolism Methods Multiple sclerosis Nervous system Nervous system diseases Neurodegeneration Neurofilament Proteins - blood Neurofilament Proteins - cerebrospinal fluid Neurofilaments Neurological diseases Neurology Neurosciences Patients Physical Sciences Proteins Quality Quality assessment Quality control Research and Analysis Methods Studies Systematic review |
| title | Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis |
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