A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1

In the context of the human airway, interleukin-17A (IL-17A) signaling is associated with severe inflammation, as well as protection against pathogenic infection, particularly at mucosal surfaces such as the airway. The intracellular molecule Act1 has been demonstrated to be an essential mediator of...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0163323
Hauptverfasser:	Velichko, Sharlene, Zhou, Xu, Zhu, Lingxiang, Anderson, Johnathon David, Wu, Reen, Chen, Yin
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adaptor Proteins, Signal Transducing Asthma Bacterial infections beta-Defensins - biosynthesis beta-Defensins - genetics Binding Biology and Life Sciences Chemokines Cloning Cytokines Cytoplasm Enzymatic activity Enzymes Epithelial cells Gene expression Genes Health aspects Humans Immunoglobulins Immunology Infection Interleukin 17 Interleukin-17 - biosynthesis Interleukin-17 - genetics Interleukins Internal medicine Intracellular Kinases Localization Medicine Molecular biology Mucosa NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Nuclei Pharmacology Pharmacy Promoters (Genetics) Protein binding Protein Domains Proteins Research and Analysis Methods Respiratory tract Response Elements - physiology Rodents Signal Transduction - physiology Signaling Toxicology Transcription Transcription (Genetics) Transcription, Genetic - physiology Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism Ubiquitin Ubiquitin-protein ligase Up-Regulation - physiology
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