Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation

Thioredoxin (Trx) is an oxidoreductase with important physiological function. Imbalances in the NADPH/thioredoxin reductase/thioredoxin system are associated with a number of pathologies, particularly cancer, and a number of clinical trials for thioredoxin and thioredoxin reductase inhibitors have b...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0163006-e0163006
Hauptverfasser:	Metcalfe, Clive, Ramasubramoni, Anjana, Pula, Giordano, Harper, Matthew T, Mundell, Stuart J, Coxon, Carmen H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Activation Agglutination Antiplatelet therapy Apoptosis Benzothiazoles - pharmacology Binding sites Biology and Life Sciences Blood clots Blood Coagulation Tests - methods Blood platelets Blood Platelets - drug effects Blood Platelets - metabolism Cancer Cell surface Chemical bonds Clinical trials Collagen Disulfides - pharmacology Endothelium Enzymes Humans Hydroquinones - pharmacology Imidazoles - pharmacology Inhibition Inhibitors Kinases Ligands Medical research Medicine and Health Sciences NADP Neurosciences Oxidation Oxidoreductase Oxidoreductases Pathology Peptides Pharmacology Physical Sciences Physiological aspects Physiology Platelet Activation - drug effects Platelet Adhesiveness - drug effects Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Platelet Function Tests - methods Platelet Membrane Glycoproteins - metabolism Platelets Proteins Proteomics Receptors Receptors, Collagen - metabolism Reductase Ristocetin Ristocetin - pharmacology Rutin Substrates Thiols Thioredoxin Thioredoxins Thioredoxins - pharmacology Thromboembolism Thrombosis Thrombosis - drug therapy Thrombosis - metabolism Valence Von Willebrand factor von Willebrand Factor - metabolism
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