JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases

The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia areata. Patients suffering from other ISDs might a...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164080-e0164080
Hauptverfasser:	Alves de Medeiros, Ana Karina, Speeckaert, Reinhart, Desmet, Eline, Van Gele, Mireille, De Schepper, Sofie, Lambert, Jo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adolescent Adult Aged Aged, 80 and over Alopecia Atopic dermatitis Autoimmune diseases Baldness Biology and Life Sciences Biopsy Care and treatment Child Child, Preschool Chronic conditions Cutaneous Lupus Erythematosus Cytokines Dermatitis Dermatologic agents Dermatology Diseases Eczema Epidermis Feasibility studies Female Formulations Gene expression Gene Expression Regulation, Enzymologic - drug effects Humans Immune system Infant Inflammation - complications Inflammatory diseases Inhibitors Janus kinase Janus kinase 2 Janus Kinase 3 - antagonists & inhibitors Janus Kinase 3 - genetics Janus Kinase 3 - metabolism Keratinocytes Kinases Lichen planus Lupus Male Medical treatment Medicine and Health Sciences Middle Aged Molecular Targeted Therapy Phosphorylation Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Psoriasis Pyoderma Pyoderma gangrenosum Research and Analysis Methods Rodents Signal transduction Signaling Skin Skin - drug effects Skin - metabolism Skin - pathology Skin diseases Skin Diseases - complications Skin Diseases - drug therapy Skin Diseases - enzymology STAT Transcription Factors - genetics STAT Transcription Factors - metabolism Tyk2 protein Young Adult
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