Progressive Dystrophic Pathology in Diaphragm and Impairment of Cardiac Function in FKRP P448L Mutant Mice

Mutations in the gene for fukutin-related protein represent a subset of muscular dystrophies known as dystroglycanopathies characterized by loss of functionally-glycosylated-alpha-dystroglycan and a wide range of dystrophic phenotypes. Mice generated by our lab containing the P448L mutation in the f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164187-e0164187
Hauptverfasser:	Blaeser, Anthony, Awano, Hiroyuki, Wu, Bo, Lu, Qi-Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - genetics Aging - metabolism Aging - pathology Animals Biology and Life Sciences Cardiac muscle Cardiac output Cardiomyopathy Congenital diseases Cytology Diaphragm Diaphragm (anatomy) Diaphragm - pathology Disease Disease Progression Dystroglycan Dystroglycans - metabolism Electrocardiography FCMD protein Fibrosis Genetic aspects Glycosylation Heart Heart - physiopathology Heart diseases Histology Infiltration Laboratories Medicine and Health Sciences Mice Mice, Inbred C57BL Muscles Muscular Dystrophies - genetics Muscular Dystrophies - metabolism Muscular Dystrophies - pathology Muscular Dystrophies - physiopathology Muscular dystrophy Mutation Myocardium - metabolism NMR Nuclear magnetic resonance Pathology Phenotype Proteins Proteins - genetics Research and Analysis Methods Rodents Transferases Ultrasound
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!