Complete Protection against Influenza Virus H1N1 Strain A/PR/8/34 Challenge in Mice Immunized with Non-Adjuvanted Novirhabdovirus Vaccines

Novirhabdoviruses like Viral Hemorrhagic Septicemia Virus (VHSV) and Infectious Hematopoietic Necrosis Virus (IHNV) are fish-infecting Rhabdoviruses belonging to the Mononegavirales order. By reverse genetics, we previously showed that a recombinant VHSV expressing the West Nile Virus (WNV) E glycop...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164245-e0164245
Hauptverfasser:	Rouxel, Ronan N, Mérour, Emilie, Biacchesi, Stéphane, Brémont, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibody response Antigens Biology and life sciences Carps Cell Line Dogs Female Fluorescent Antibody Technique, Indirect Genetics Genomes Glycoproteins Hemagglutinins Hemagglutinins - genetics Hemagglutinins - immunology Hemagglutinins - metabolism Hemorrhage Hemorrhagic septicemia Immunization Infections Infectious hematopoietic necrosis Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - pathogenicity Influenza vaccines Influenza viruses Lectins Lethal dose Life Sciences Madin Darby Canine Kidney Cells Medical research Medicine and Health Sciences Mice Mice, Inbred BALB C Microscopy, Electron Mutagenesis Novirhabdovirus - immunology Novirhabdovirus - metabolism Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Pandemics Plasmids - genetics Plasmids - metabolism Production capacity Proteins Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - immunology Research and Analysis Methods Septicemia Swine flu Vaccination Vaccines Vaccines, Synthetic - immunology Viruses West Nile fever West Nile virus Wildlife conservation
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