Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy

Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide but current treatments remain suboptimal. The role of inflammation in DN has only recently been recognized. It has been shown that the NLRP3-inflammasome contributes to DN development by inducing interleukin (IL)-1β...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164135-e0164135
Hauptverfasser:	Yuan, Fang, Kolb, Ryan, Pandey, Gaurav, Li, Wei, Sun, Lin, Liu, Fuyou, Sutterwala, Fayyaz S, Liu, Yinghong, Zhang, Weizhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adapter proteins Albumin Animals Biology and Life Sciences Blood glucose Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cancer CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - metabolism Chronic kidney failure Cytokines Diabetes Diabetes mellitus Diabetic nephropathies Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic nephropathy Disease Disease Models, Animal Disease Progression End-stage renal disease Excretion Histology Hospitals Humans IL-1β Immunology Inflammasomes Inflammasomes - genetics Inflammasomes - metabolism Inflammation Interdisciplinary aspects Interleukin Interleukin-1beta - metabolism Interleukins Kidney - metabolism Kidney diseases Kidneys Kinases Macrophages Macrophages - metabolism MAP kinase Medical treatment Medicine Medicine and Health Sciences Metabolism Mice Nephrology Nephropathy NF-κB protein Obesity Pathogens Pathology Pathways Research and Analysis Methods Rodents Signal Transduction Signaling Transplants & implants Type 2 diabetes Up-Regulation
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